Abstract
18F-NaF was used as a bone-seeking PET tracer for skeletal imaging until the introduction of the widely available 99mTc-labeled bone agents. However, there is renewed clinical interest in 18F-NaF since prior technical and logistic limitations to its routine use are no longer present, and, as a consequence, it is likely that uptake unrelated to bone and non-osseous findings will be encountered more frequently. As a result of tumoral necrosis, soft tissue metastases may demonstrate 18F-NaF avidity due to dystrophic calcification. On the other hand, all non-osseous findings, whether 18F-NaF avid or not, may provide important diagnostic information that may alter the course of the disease, including treatment options. Herein we present a patient with ductal carcinoma of the breast in whom findings unrelated to the skeletal system in 18F-NaF PET/CT altered the treatment strategy.
References
Grant FD, Fahey FH, Packard AB, Davis RT, Alavi A, Treves ST. Skeletal PET with 18F-fluoride: applying new technology to an old tracer. J Nucl Med. 2008;49(1):68–78.
Tateishi U, Morita S, Taguri M, Shizukuishi K, Minamimoto R, Kawaguchi M, et al. A meta-analysis of (18)F-fluoride positron emission tomography for assessment of metastatic bone tumor. Ann Nucl Med. 2010;24(7):523–31.
Nishiyama Y, Tateishi U, Shizukuishi K, Shishikura A, Yamazaki E, Shibata H, et al. Role of 18F-fluoride PET/CT in the assessment of multiple myeloma: initial experience. Ann Nucl Med. 2013;27(1):78–83.
Pirayesh E, Rakhshan A, Amoui M, Rakhsha A, Poor AS, Assadi M. Metastasis of femoral osteosarcoma to the abdominal wall detected on 99mTc-MDP skeletal scintigraphy. Ann Nucl Med. 2013. doi:10.1007/s12149-013-0708-6.
Basu S, Kembhavi S. Serendipitous observation of hepatic metastases on (18)F-fluoride PET in a patient with infiltrating ductal carcinoma of breast: correlation with contrast enhanced CT. Clin Nucl Med. 2012;37(12):1176–8.
Sheth S, Colletti PM. Atlas of sodium fluoride PET bone scans: atlas of NaF PET bone scans. Clin Nucl Med. 2012;37(5):e110–6.
Swiętaszczyk C, Prasad V, Baum RP. Intense 18F-fluoride accumulation in liver metastases from a neuroendocrine tumor after peptide receptor radionuclide therapy. Clin Nucl Med. 2012;37(4):e82–3.
Stewart VL, Herling P, Dalinka MK. Calcification in soft tissues. JAMA. 1983;250(1):78–81.
Acknowledgments
All authors declare no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kuyumcu, S., Adalet, I., Isik, E.G. et al. Impact of Nonosseous Findings on 18F-NaF PET/CT in a Patient with Ductal Breast Carcinoma. Nucl Med Mol Imaging 48, 72–74 (2014). https://doi.org/10.1007/s13139-013-0235-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13139-013-0235-3