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In the shadow of resveratrol: biological activities of epsilon-viniferin

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A Correction to this article was published on 11 June 2022

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Abstract

Stilbenes are secondary metabolites belonging to the polyphenol family. Those compounds are derived from the glycosylation, prenylation, methoxylation, hydroxylation, or also oligomerization of the well-known trans-resveratrol. One of them, trans-epsilon-viniferin (ε-viniferin), is a trans-resveratrol dimer that arouses the interest of researchers in the field of human health. The biosynthesis of this molecule in various plant species, particularly high in the Vitaceae family, explains its presence in some red wines, which represent the main source of ε-viniferin in the human diet. Although bioavailability studies have shown poor absorption and high metabolism of this stilbene, multiple studies demonstrated its biological properties. The ε-viniferin exhibits strong activities against inflammatory and oxidative stress. Moreover, various studies have reported great activity of this compound not only in a wide range of disorders and diseases, such as cancer, obesity, and its associated disorders, but also in vascular diseases and neurodegeneration, for which the pathophysiology is closely related to the state of oxidation and inflammation. This review provides a state of art of the main activities of ε-viniferin demonstrated in vitro and in vivo, highlighting that this resveratrol dimer could be a promising candidate for future functional foods or supplement foods used for the management of many chronic diseases of concern in terms of public health.

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Authors and Affiliations

  1. Université de Bordeaux, UR Œnologie, MIB, EA 4577, USC 1366 INRAE, 33882, Villenave d’Ornon, France

    Pauline Beaumont, Arnaud Courtois, Tristan Richard & Stéphanie Krisa

  2. Bordeaux INP, UR Œnologie, MIB, EA 4577, USC 1366 INRAE, 33882, Villenave d’Ornon, France

    Pauline Beaumont, Arnaud Courtois, Tristan Richard & Stéphanie Krisa

  3. Centre Antipoison et de Toxicovigilance de Nouvelle Aquitaine, Bâtiment UNDR, CHU de Bordeaux, 33076, Bordeaux, France

    Arnaud Courtois

  4. Université de Bordeaux, CBMN, UMR 5248, 33600, Pessac, France

    Claude Atgié

  5. Bordeaux INP, CBMN, UMR 5248, 33600, Pessac, France

    Claude Atgié

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Beaumont, P., Courtois, A., Atgié, C. et al. In the shadow of resveratrol: biological activities of epsilon-viniferin. J Physiol Biochem 78, 465–484 (2022). https://doi.org/10.1007/s13105-022-00880-x

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