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The association of insulin resistance with serum osteoprotegerin in obese adolescents

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Abstract

Some data indicate a potential relationship between insulin resistance level and the concentration of osteoprotegerin (OPG) in the body. There have been few studies concerning OPG level and its relationship with insulin resistance and body composition in young people. The aim of this study was to assess serum osteoprotegerin concentration in obese adolescents, and to evaluate its potential association with insulin resistance. Seventy-eight obese adolescents and 20 healthy volunteers aged 12–18 years were recruited in the study. Selected anthropometrical measurements and blood biochemical analyses were performed. Insulin resistance in the participants was evaluated according to the homeostasis model assessment-insulin resistance (HOMA-IR) protocol. Level of OPG was assessed in serum. Obese subjects had significantly higher HOMA-IR indices and OPG levels in serum than the control group. A significant positive correlation between OPG and insulin resistance was found. It was observed that high concentrations of osteoprotegerin are associated with insulin resistance in obese adolescents.

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Acknowledgments

The research was supported by grants from the Ministry of Science and Higher Education, Poland (0287/B/P01/2008/35).

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Authors and Affiliations

  1. Department of Human Nutrition and Hygiene, Poznan University of Life Sciences, Wojska Polskiego 31 Str., 60-624, Poznań, Poland

    Joanna Suliburska

  2. Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Szamarzewskiego84 Str., 60-569, Poznań, Poland

    Pawel Bogdanski

  3. Department of Physiotherapy, Poznan University of Medical Sciences, 28 Czerwca 1956 r. 135/147 Str., 61-545, Poznań, Poland

    Ewa Gajewska

  4. Health Resort Hospital No 3., Staszica 5 Str., 87-720, Ciechocinek, Poland

    Grazyna Kalmus

  5. Department of Physiotherapy, Rheumatology and Rehabilitation, Poznan University of Medical Sciences, 28 Czerwca 1956 r. 135/147 Str., 61-545, Poznań, Poland

    Magdalena Sobieska & Wlodzimierz Samborski

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  1. Joanna Suliburska
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  2. Pawel Bogdanski
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  3. Ewa Gajewska
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  5. Magdalena Sobieska
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Correspondence to Joanna Suliburska.

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Suliburska, J., Bogdanski, P., Gajewska, E. et al. The association of insulin resistance with serum osteoprotegerin in obese adolescents. J Physiol Biochem 69, 847–853 (2013). https://doi.org/10.1007/s13105-013-0261-8

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  • DOI: https://doi.org/10.1007/s13105-013-0261-8

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