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Cardiovascular effects of black tea and nicotine alone or in combination against experimental induced heart injury

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Abstract

The present study was designed to elucidate the outcome of subchronic co-administration of black tea and nicotine on cardiovascular performance and whether these substances could modulate the isoproterenol-induced cardiac injury. Animal groups were control, black tea, nicotine and black tea plus nicotine. Test groups received nicotine (2 mg/kg s.c.) and black tea brewed (p.o.) each alone and in combination for 4 weeks. On the 28th day, myocardial damage was induced by isoproterenol (50 mg/kg i.p.), and blood samples were taken. On day 29, after hemodynamic parameters recording, hearts were removed for histopathological evaluation. Tea or nicotine consumption had no significant effects on hemodynamic indices of animals without heart damage. When the cardiac injury was induced, tea consumption maintained the maximum dp/dt, and nicotine significantly decreased the pressure–rate product. Moreover, severity of heart lesions was lower in the presence of nicotine or black tea. Concomitant use of these materials did not show extra effects on mentioned parameters more than the effect of each of them alone. The results suggest that subchronic administration of black tea or nicotine for a period of 4 weeks may have a mild cardioprotective effect, while concomitant use of these materials cannot intensify this beneficial effect.

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Acknowledgments

The authors are grateful to the Neuroscience Research Center, Kerman University of Medical Sciences, for the financial support of this work.

Conflict of interest

The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Neuroscience Research Center, Kerman University of Medical Sciences, P.O. Box 7616914115, Kerman, Iran

    Siyavash Joukar & Kouros Divsalar

  2. Physiology Research Center, Kerman University of Medical Sciences, P.O. Box 7616914115, Kerman, Iran

    Siyavash Joukar, Payam Ghotbi & Farzin Joukar

  3. Department of Physiology and Pharmacology, Afzalipour Medical Faculty, Kerman University of Medical Sciences, P.O. Box 7616914115, Kerman, Iran

    Siyavash Joukar & Payam Ghotbi

  4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Hamideh Bashiri

  5. Department of Pathology, Afzalipour Medical Faculty, Kerman University of Medical Sciences, P.O. Box 7616914115, Kerman, Iran

    Shahriar Dabiri & Mahsa Abbaszadeh

  6. Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Arash Sarveazad

  7. High school of Allame Helli, Education of Kerman province, Kerman, Iran

    Farzin Joukar

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  1. Siyavash Joukar
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Joukar, S., Bashiri, H., Dabiri, S. et al. Cardiovascular effects of black tea and nicotine alone or in combination against experimental induced heart injury. J Physiol Biochem 68, 271–279 (2012). https://doi.org/10.1007/s13105-011-0141-z

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  • DOI: https://doi.org/10.1007/s13105-011-0141-z

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