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Do Current Animal Models of Intracerebral Hemorrhage Mirror the Human Pathology?

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Abstract

Although intracerebral hemorrhage (ICH) has no proven treatment, well-designed studies using animal models of ICH may lead to the development of novel therapies. We briefly review current animal models of ICH. Furthermore, we discuss how these models may be utilized and targeted to facilitate translation of preclinical findings to the clinical arena.

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Authors and Affiliations

  1. Department of Emergency Medicine, University of Cincinnati, Cincinnati, OH, USA

    Opeolu Adeoye

  2. Department of Neurosurgery, University of Cincinnati, Cincinnati, OH, USA

    Opeolu Adeoye, Mario Zuccarello & Gail J. Pyne-Geithman

  3. Department of Neurology, University of Cincinnati, Cincinnati, OH, USA

    Joseph F. Clark, Pooja Khatri & Kenneth R. Wagner

  4. Veterans Administration Medical Center, Cincinnati, OH, USA

    Kenneth R. Wagner

  5. Division of Neurocritical Care, Department of Emergency Medicine, UC Neuroscience Institute, University of Cincinnati Medical Center, 231 Albert Sabin Way, ML 0769, Cincinnati, OH, 45267-0525, USA

    Opeolu Adeoye

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  1. Opeolu Adeoye
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Correspondence to Opeolu Adeoye.

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Adeoye, O., Clark, J.F., Khatri, P. et al. Do Current Animal Models of Intracerebral Hemorrhage Mirror the Human Pathology?. Transl. Stroke Res. 2, 17–25 (2011). https://doi.org/10.1007/s12975-010-0037-1

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  • DOI: https://doi.org/10.1007/s12975-010-0037-1

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