Abstract
The purpose of this study is to examine the utility of magnetic resonance imaging (MRI) T2* sequences as a measure of iron overload in the brain following intracerebral hemorrhage (ICH). We examined the time course of T2* changes in the brain around intracerebral hemorrhages in a series of patients. We also performed a series of experiments in an animal model of ICH, examining the time course of T2* changes along with correlation of these changes with histological markers of ferric iron deposition. We found that T2* changes in the brain occur with increasing intensity and spatial distribution over a 3-month period. Experimental ICH in the rat model induces similar changes, and these changes correlate tightly with histological markers of ferric iron deposition. MRI T2* changes after ICH can be used to measure the degree of iron overload in the brain. The T2* sequence may be useful as a measure of interventions aimed at reducing ICH-related brain injury by reducing iron deposition.
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Acknowledgment
This study was supported by grants NS-017760, NS-039866, NS-047245, NS-052510 and NS-057539 from the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
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Wu, G., Xi, G., Hua, Y. et al. T2* Magnetic Resonance Imaging Sequences Reflect Brain Tissue Iron Deposition Following Intracerebral Hemorrhage. Transl. Stroke Res. 1, 31–34 (2010). https://doi.org/10.1007/s12975-009-0008-6
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DOI: https://doi.org/10.1007/s12975-009-0008-6