Abstract
Background
Human thrombin appears to be a new effective tool in the armamentarium of management of bleeding gastric varices, but there are paucity of data on its use. Thus, we share our experience with human thrombin in the treatment of bleeding gastric varices.
Methods
It was a prospective interventional study conducted between September 2015 and December 2017. Patients with upper gastrointestinal bleeding from gastric varices were included, while patients with previous history of cyanoacrylate glue injection or band ligation were excluded.
Results
A total of 20 patients including 13 males (mean age 32.65 [18–52] years) presenting with gastric variceal bleeding requiring endoscopic injection of human thrombin were studied. The underlying diagnosis was cirrhosis in 8 patients, and extrahepatic portal vein thrombosis, noncirrhotic portal fibrosis, and chronic pancreatitis in 6, 4, and 2 patients, respectively. Isolated gastric varices were found in 6 patients while 14 patients had gastroesophageal varices (GOV) (GOV1–3, GOV2–11). Patients received 1 to 3 sessions (mean = 1.3) of thrombin with a mean total dose of 700 IU (range = 500–2000 IU). Mean follow up was 16.8 months (range 3–28 months). Hemostasis in the acute setting was successfully managed in all the 20 patients on initial presentation. On serial follow up, 4 out of 20 patients required repeat endoscopic session for gastric varices. No thrombin injection-related complication was recorded.
Conclusion
Endoscopic therapy with thrombin appears safe and effective in the management of bleeding gastric varices.
Similar content being viewed by others
References
Sarin SK, Lahoti D, Saxena SP, Murthy NS, Makwana UK. Prevalence, classification and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology. 1992;16:1343–9.
Thakeb F, Salem SA, Abdallah M, et al. Endoscopic diagnosis of gastric varices. Endoscopy. 1994;26:287–91.
Carbonell N, Pauwels A, Serfaty L, Fourdan O, Lévy VG, Poupon R. Improved survival after variceal bleeding in patients with cirrhosis over the past two decades. Hepatology. 2004;40:652–9.
Stokkeland K, Brandt L, Ekbom A, Hultcrantz R. Improved prognosis for patients hospitalized with esophageal varices in Sweden 1969-2002. Hepatology. 2006;43:500–5.
Hou MC. Developments in the treatment of acute esophageal variceal bleeding. J Chin Med Assoc. 2006;69:55–7.
Sarin SK, Jain AK, Jain M, Gupta R. A randomized controlled trial of cyanoacrylate versus alcohol injection in patients with isolated fundic varices. Am J Gastroenterol. 2002;97:1010–5.
Tan PC, Hou MC, Lin HC, et al. A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation. Hepatology. 2006;43:690–7.
Hou MC, Lin HC, Lee HS, et al. A randomized trial of endoscopic cyanoacrylate injection for acute gastric variceal bleeding: 0.5 mL versus 1.0 mL. Gastrointest Endosc. 2009;70:668–75.
Kind R, Guglielmi A, Rodella L, et al. Bucrylate treatment of bleeding gastric varices: 12 years’ experience. Endoscopy. 2000;32:512–9.
Akahoshi T, Hashizume M, Shimabukuro R, et al. Long-term results of endoscopic Histoacryl injection sclerotherapy for gastric variceal bleeding: a 10-year experience. Surgery. 2002;131:S176–81.
Ramond MJ, Valla D, Mosnier JF, et al. Successful endoscopic obturation of gastric varices with butyl cyanoacrylate. Hepatology. 1989;10:488–93.
See A, Florent C, Lamy P, et al. Cerebrovascular accidents after endoscopic obturation of esophageal varices with isobutyl-2- cyanoacrylate in 2 patients. Gastroenterol Clin Biol. 1986;10:604–7.
Cheng PN, Sheu BS, Chen CY, Chang TT, Lin XZ. Splenic infarction after Histoacryl injection for bleeding gastric varices. Gastrointest Endosc. 1998;48:426–7.
Roesch W, Rexroth G. Pulmonary, cerebral and coronary emboli during bucrylate injection of bleeding fundic varices. Endoscopy. 1998;30:S89–90.
Chang CJ, Shiau YT, Chen TL, et al. Pyogenic portal vein thrombosis as a reservoir of persistent septicemia after cyanoacrylate injection for bleeding gastric varices. Digestion. 2008;78:139–43.
Sarin SK, Kumar A. Gastric varices: profile, classification and management. Am J Gastrenterol. 1989;84:1244–9.
Hashizume M, Kitano S, Yamaga H, Koyanagi N, Sugimachi K. Endoscopic classification of gastric varices. Gastrointest Endosc. 1990;36:276–80.
Sarin SK. Long-term follow-up of gastric variceal sclerotherapy: an eleven-year experience. Gastrointest Endosc. 1997;46:8–14.
Sarin SK, Sachdev G, Nanda R, Misra SP, Broor SL. Endoscopic sclerotherapy in the treatment of gastric varices. Br J Surg. 1988;75:747–50.
Gimson AE, Westaby D, Williams R. Endoscopic sclerotherapy in the management of gastric variceal haemorrhage. J Hepatol. 1991;13:274–8.
Korula J, Chin K, Ko Y, Yamada S. Demonstration of two distinct subset of gastric varices. Observations during a seven-year study of endoscopic sclerotherapy. Dig Dis Sci. 1991;36:303–9.
Maluf-Filho F, Sakai P, Ishioka S, Matuguma SE. Endoscopic sclerosis versus cyanoacrylate endoscopic injection for the first episode of variceal bleeding: a prospective, controlled, and randomized study in Child-Pugh class C patients. Endoscopy. 2001;33:421–7.
Lo GH, Lai KH, Cheng JS, Chen MH, Chiang HT. A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices. Hepatology. 2001;33:1060–4.
Williams SG, Peters RA, Westaby D. Thrombin – an effective treatment for gastric variceal haemorrhage. Gut. 1994;35:1287–9.
Przemioslo RT, McNair A, Williams R. Thrombin is effective in arresting bleeding from gastric variceal hemorrhage. Dig Dis Sci. 1999;44:778–81.
Snobl J, Van Buuren HR, Van Blankenstein M. Endoscopic injection using thrombin: an effective and safe method for controlling oesophagogastric variceal bleeding (Abst.). Gastroenterology. 1992;102:A891.
Yang WL, Tripathi D, Therapondos G, Todd A, Clive Hayes P. Endoscopic use of human thrombin in bleeding gastric varices. Am J Gastroenterol. 2002;97:1381–5.
Heneghan MA, Byrne A, Harrison PM. An open pilot study of the effects of a human fibrin glue for endoscopic treatment of patients with acute bleeding from gastric varices. Gastrointest Endosc. 2002;56:422–6.
Datta D, Vlavianos P, Alisa A, Westaby D. Use of fibrin glue (beriplast) in the management of bleeding gastric varices. Endoscopy. 2003;35:675–8.
Ramesh J, Limdi JK, Sharma V, Makin AJ. The use of thrombin injections in the management of bleeding gastric varices: a single-center experience. Gastrointest Endosc. 2008;68:877–82.
McAvoy NC, Plevris JN, Hayes PC. Human thrombin for the treatment of gastric and ectopic varices. World J Gastroenterol. 2012;18:5912–7.
Daly BM. Use of buffer thrombin in the treatment of gastric hemorrhage; a preliminary report. Arch Surg. 1947;55:208–12.
Krystallis C, McAvoy NC, Wilson J, Hayes PC, Plevris JN. EUS-assisted thrombin injection for ectopic bleeding varices- -a case report and review of the literature. QJM. 2012;105:355–8.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
AJ, SJW, PA, RP, and SN declare that they have no conflict of interest.
Informed consent
Written informed consent was taken from all the subjects.
Ethics statement
The authors declare that the study was performed in a manner to conform with the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com.
Disclaimer
The authors are solely responsible for the findings and the content of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, or the printer/publishers are responsible for the results/findings and content of this article.
Rights and permissions
About this article
Cite this article
Jhajharia, A., Wanjari, S.J., Ashdhir, P. et al. Role and safety of human thrombin injection for the treatment of bleeding gastric varices. Indian J Gastroenterol 37, 321–325 (2018). https://doi.org/10.1007/s12664-018-0877-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12664-018-0877-2