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Statin use does not prevent recurrent adenomatous polyp formation in a VA population

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Abstract

Purpose

To evaluate whether statin use was associated with recurrent adenomatous polyps.

Methods

We conducted a retrospective cohort study. We used electronic health records to evaluate veterans who underwent polypectomy between January 1, 1999 and December 31, 2001 and surveillance colonoscopy by December 2006. We obtained data on pathology, demographics, body mass index, comorbidity, habits, family history, and medications. We used multivariate proportional hazards regression models to analyze data.

Results

We evaluated 197 eligible patients from among 821 who underwent colonoscopy during this period; their mean (SD) age was 63.1 (8.8) years, 192 (98%) were men, and 80 (41%) non-Hispanic white. Surveillance colonoscopy was performed after a mean (SD) 1207 (452) days and 108 (55%) patients had recurrent adenomas. During follow-up, 88 (47%) of patients received statins, but use was not protective against recurrent adenomas (hazard ratio = 1.36, 95% CI 0.35–8.27). Only number of polyps at initial colonoscopy predicted recurrent adenomas (1.98, 95% CI 1.27–3.08).

Conclusions

The use of statins was not protective against the recurrence of adenomatous polyps.

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Acknowledgments

This work was supported by the Medicine Service, Albuquerque VA Medical Center.

Conflicts of Interest

None of the authors have any conflicts to declare.

Author information

Authors and Affiliations

  1. Southwest Gastroenterology, Albuquerque, NM, USA

    Nikki Parker-Ray

  2. University of New Mexico School of Medicine, Albuquerque, NM, USA

    Jehad Barakat, Ronald M. Schrader & Richard M. Hoffman

  3. New Mexico VA Health Care System, Mailstop 111, 1501 San Pedro Drive SE, Albuquerque, NM, 87108, USA

    Jehad Barakat & Richard M. Hoffman

  4. Albuquerque Health Partners, Albuquerque, NM, USA

    Praveen K. Roy

  5. Lovelace Clinic Foundation, Albuquerque, NM, USA

    Robert E. White

Authors
  1. Nikki Parker-Ray
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  2. Jehad Barakat
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  3. Praveen K. Roy
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  4. Robert E. White
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  5. Ronald M. Schrader
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  6. Richard M. Hoffman
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Corresponding author

Correspondence to Richard M. Hoffman.

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Parker-Ray, N., Barakat, J., Roy, P.K. et al. Statin use does not prevent recurrent adenomatous polyp formation in a VA population. Indian J Gastroenterol 29, 106–111 (2010). https://doi.org/10.1007/s12664-010-0032-1

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  • DOI: https://doi.org/10.1007/s12664-010-0032-1

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