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Global Scenario of Research in Oral Cancer

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Abstract

Introduction

With 300,000 new cases diagnosed worldwide, oral cancer continues to be a major global public threat. In Indian subcontinent, oral cancer accounts for 30–40% of all cancer types.

Methodology

Early detection of oral cancer is still considered as the most effective way to improve survival. In this regard, early detection of oral premalignant lesions and conditions is quite important as it may help in prevention of oral cancer. Scientific evidence is available which clearly indicates that transition from normal epithelium to premalignancy to oral carcinoma is the result of accumulation of genetic and epigenetic alterations in a multi-step process.

Conclusion

Proper oral screening and understanding of the genetic and environmental factors involved in oral carcinogenesis will allow the emphasis of cancer medicine to shift from the therapy of established oral cancer to the prevention of oral carcinogenesis.

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References

  1. Brakhuis BJ, Brakenhoff RH (2005) Humans R head and neck cancer: molecular carcinogenesis. Ann Oncol 16(2):249–250

    Article  Google Scholar 

  2. Hunter KD, Parkinson EK, Harrison PR (2005) Profiling early and neck cancer. Nat Res Cancer 5:127–135

    Article  CAS  Google Scholar 

  3. Gupta PC, Warnakulasuriya S (2002) Global epidemiology of areca nut usage. Addict Biol 7(1):77–83

    Article  CAS  PubMed  Google Scholar 

  4. Hebert JR, Gupta PC, Bhonsle RB et al (2002) Dietary exposures and oral precancerous lesions in Srikakulam District, Andhra Pradesh Karnataka India. Public Health Nutr 5:303–312

    Article  PubMed  Google Scholar 

  5. Jayalekshmi PA, Gangadharan P, Akiba S, Nair RRK, Tsuji M, Rajan B (2009) Tobacco chewing and female oral cavity cancer risk in Karunagappally cohort, India. Br J Cancer 100:848–852

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L et al (2000) Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92:709–720

    Article  CAS  PubMed  Google Scholar 

  7. Loeb LA (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075–3079

    CAS  PubMed  Google Scholar 

  8. Sreelekha TT, Ramadas K, Pandey M, Thomas G, Nalinakumari KR, Pillai MR (2001) Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer. Oral Oncol 37:593–598

    Article  CAS  PubMed  Google Scholar 

  9. Sikdar N, Mahmud SA, Paul RR, Roy B (2003) Polymorphism in CYP1A1 and CYP2E1 genes and susceptibility to leukoplakia in Indian tobacco users. Cancer Lett 195:33–42

    Article  CAS  PubMed  Google Scholar 

  10. Anantharaman D, Chaubal PM, Kannan S, Bhisey RA, Mahimkar MB (2007) Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator. Carcinogenesis 28:1455–1462

    Article  CAS  PubMed  Google Scholar 

  11. Buch SC, Nazar-Stewart V, Weissfeld JL, Romkes M (2008) Case–control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. Head Neck 30:1139–1147

    Article  PubMed  PubMed Central  Google Scholar 

  12. Majumder PK et al (2004) mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med 10:594–601

    Article  CAS  PubMed  Google Scholar 

  13. Sathyan P, Golden HB, Miranda RC (2007) Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure. J Neurosci 27:8546–8557

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Sailasree R, Nalinakumari KR, Sebastian P, Kannan S (2011) Influence of methylene tetrahydrofolate reductase polymorphisms in oral cancer patients. J Oral Pathol Med 40:61–66

    Article  CAS  PubMed  Google Scholar 

  15. Mithani SK, Taube JM, Zhou S, Smith IM, Koch WM, Westra WH, Califano JA (2007) Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res 13:4331–4335

    Article  CAS  PubMed  Google Scholar 

  16. Chakraborty SB, Dasgupta S, Roy A et al (2003) Different head and neck squamous cell carcinoma from Indian patents. Cancer Genet Cytogenet 145:1–9

    Article  CAS  Google Scholar 

  17. Saranath D, Chang SE, Bhoite LT et al (1991) High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India. Br J Cancer 63(4):573–578

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Murti PR, Warnakulasuriya KA, Johnson NW et al (1998) p53 expression in oral precancer as a marker for malignant potential. J Oral Pathol Med 27:191–196

    Article  CAS  PubMed  Google Scholar 

  19. Ralhan R, Desouza LV, Matta A, Chandra Tripathi S, Ghanny S et al (2008) Discovery and verification of head-and-neck cancer biomarkers by differential protein expression analysis using iTRAQ labeling, multidimensional liquid chromatography, and tandem mass spectrometry. Mol Cell Proteom 7:1162–1173

    Article  CAS  Google Scholar 

  20. Sabbir G, Roy A, Mandol S, Dam A, Roychaudary S, Panda CK (2006) Deletion mapping of chromosome 13Qin head and neck squamous cell carcinoma in Indian patients: correlation with prognosis of the tumor. Exp Pathol 87:151–161

    Article  CAS  Google Scholar 

  21. Ghosh S, Ghosh A, Maiti GP et al (2008) Alterations of 3p2.131 tumor suppressor genes in head and neck squamous cell carcinoma. Correlation with progression and prognosis. Int J Cancer 123(11):2594–2604

    Article  CAS  PubMed  Google Scholar 

  22. Sharp TV, Munoz F, Bourboutia D et al (2004) LIM domains containing protein! (LIMDI) a tumor suppressor encoded at chromosome 3p21.3 binds pRB and represses E2 F Driven transcription. Proc Natl Acad Sci 101:16531–16536

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Ghosh S, Ghosh A, Maiti GP et al (2010) LIMDI is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications. Mol Cancer 9:58–70

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Subramanian S et al (2009) Cost-effectiveness of oral cancer screening: results from a cluster randomized controlled trial in India. Bull World Health Organ 87(3):200–206

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, P.M.S College of Dental Sciences and Research, Kerala University of Health Sciences, Trivandrum, India

    Vinod Nair Sreekumar

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  1. Vinod Nair Sreekumar
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Correspondence to Vinod Nair Sreekumar.

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Sreekumar, V.N. Global Scenario of Research in Oral Cancer. J. Maxillofac. Oral Surg. 18, 354–359 (2019). https://doi.org/10.1007/s12663-018-1166-4

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  • DOI: https://doi.org/10.1007/s12663-018-1166-4

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