Abstract
Adenomatoid odontogenic tumor (AOT) is an uncommon benign tumor of odontogenic origin composed of odontogenic epithelium in a variety of histopathological patterns. These lesions are usually solid but are occasionally cystic. AOT has been reported to occur in association with odontogenic cysts. Very few cases have been described that arise in association with a dentigerous cyst. A systematic search of the English-language medical literature in PubMed and Medline search (keywords adenomatoid odontogenic tumor, dentigerous cyst) data bases revealed only ten such cases.
The present case is very unique, exceptional and first of this kind that occurred in the posterior mandible associated with an impacted lower first premolar in a 19-year old female patient. The intraosseous follicular AOT, as this case reported here, frequently resemble dentigerous cysts. There is an uncertainty whether the lining of an associated cyst represents a true dentigerous cyst, cystic change within an AOT or may represent a distinct entity. We believe that this case represents an odontogenic cyst with neoplastic change. Hence, in such cases, the final diagnosis should be made on the basis of histological examination of extensive tissue sampling of entire excised tissue specimen. Further studies to determine whether the AOT derived from an odontogenic cyst could represent a distinct variant are to be done.
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References
Chuan-Xiang Z, Yan G (2007) Adenomatoid odontogenic tumor: a report of a rare case with recurrence. J Oral Pathol Med 36(7):440–443
McMillan MD, Smillie AC (1981) Ameloblastomas associated with dentigerous cysts. Oral Surg Oral Med Oral Pathol 51(5):489–496
Jivan V, Altini M, Meer S, Mahomed F (2007) Adenomatoid odontogenic tumor (AOT) originating in a unicystic ameloblastoma: a case report. Head Neck Pathol 1(2):146–149
Batra P, Prasad S, Parkash H (2005) Adenomatoid odontogenic tumour: review and case report. J Can Dent Assoc 71(4):250–253
Philipsen HP, Reichart PA, Siar CH, Ng KH, Lau SH, Zhang X et al (2007) An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study. J Oral Pathol Med 36(7):383–393
Lee JK, Lee KB, Hwang BN (2000) Adenomatoid odontogenic tumor: a case report. J Oral Maxillofac Surg 58(10):1161–1164
Philipsen HP, Birn H (1969) The adenomatoid odontogenic tumour. Ameloblastic adenomatoid tumour or adeno-ameloblastoma. Acta Pathol Microbiol Scand 75(3):375–398
Unal T, Cetingul E, Gunbay T (1995) Peripheral adenomatoid odontogenic tumor: birth of a term. J Clin Pediatr Dent 19(2):139–142
Rick GM (2004) Adenomatoid odontogenic tumor. Oral Maxillofac Surg Clin North Am 16(3):333–354
Garcia-Pola Vallejo M, Gonzalez Garcia M, Lopez-Arranz JS, Herrero Zapatero A (1998) Adenomatoid odontogenic tumor arising in a dental cyst: report of unusual case. J Clin Pediatr Dent 23(1):55–58
Tajima Y, Sakamoto E, Yamamoto Y (1992) Odontogenic cyst giving rise to an adenomatoid odontogenic tumor: report of a case with peculiar features. J Oral Maxillofac Surg 50(2):190–193
Philipsen HP, Samman N, Ormiston IW, Wu PC, Reichart PA (1992) Variants of the adenomatoid odontogenic tumor with a note on tumor origin. J Oral Pathol Med 21(8):348–352
Philipsen HP, Reichart PA, Zhang KH, Nikai H, Yu QX (1991) Adenomatoid odontogenic tumor: biologic profile based on 499 cases. J Oral Pathol Med 20(4):149–158
Slootweg PJ (1987) Carcinoma arising from reduced enamel epithelium. J Oral Pathol 16(10):479–482
Warter A, George-Diolombi G, Chazal M, Ango A (1990) Melanin in a dentigerous cyst and associated adenomatoid odontogenic tumor. Cancer 66(4):786–788
Sandhu SV, Narang RS, Jawanda M, Rai S (2010) Adenomatoid odontogenic tumor associated with dentigerous cyst of the maxillary antrum: a rare entity. J Oral Maxillofac Pathol 14(1):24–28
Valderrama LS. Dentigerous cyst with intracystic adenomatoid odontogenic tumor and complex odontoma. J Philipp Dent Assoc 1988 Dec–1989 Jan; 41(3):35–41
Takahashi K, Yoshino T, Hashimoto S (2001) Unusually large cystic adenomatoid odontogenic tumour of the maxilla: case report. Int J Oral Maxillofac Surg 30(2):173–175
Bravo M, White D, Miles L, Cotton R (2005) Adenomatoid odontogenic tumor mimicking a dentigerous cyst. Int J Pediatr Otorhinolaryngol 69(12):1685–1688
Nonaka CF, de Souza LB, Quinderé LB (2007) Adenomatoid odontogenic tumour associated with dentigerous cyst—unusual case report. Braz J Otorhinolaryngol 73(1):129–131
John JB, John RR (2010) Adenomatoid odontogenic tumor associated with dentigerous cyst in posterior maxilla: a case report and review of literature. J Oral Maxillofac Pathol 14(2):59–62
Moosvi Z, Tayaar SA, Kumar GS (2011) Neoplastic potential of odontogenic cysts. Contemp Clin Dent 2(2):106–109
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Manjunatha, B.S., Mahajan, A., Mody, B.M. et al. Adenomatoid Odontogenic Tumor (AOT) Arising from a Dentigerous Cyst: Literature Review and Report of a Case. J. Maxillofac. Oral Surg. 14, 393–397 (2015). https://doi.org/10.1007/s12663-012-0369-3
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DOI: https://doi.org/10.1007/s12663-012-0369-3