Skip to main content

Advertisement

SpringerLink
Log in

Comparative Analysis of Intralesional Sclerotherapy with Sodium Tetradecyl Sulfate Versus Bleomycin in the Management of Low Flow Craniofacial Soft Tissue Vascular Lesions

  • Comparative Study
  • Published:
Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Objective

Comparison of the efficacy of bleomycin over sodium tetradecyl sulfate (STS) when given intralesionally in the treatment of oral and maxillofacial venous malformation.

Methods

16 patients with venous malformation in craniofacial region were randomly divided into two groups of eight. Group 1 was given intralesional injection of bleomycin and group 2 was injected with STS. All the cases were evaluated for a minimum period of two and a maximum of 3 years.

Results

Efficacy of bleomycin was found to be superior to STS, when used as intralesional sclerotherapic agent. Most of the vascular lesions of group 1 resolved after first dose giving a cure rate of 87.5% and no recurrence was observed. Group 2 patients however, required 4–6, a mean of five repeated dosage of intralesional STS before their lesions started to resolve and three patients reported with recurrence within 2 years, giving an overall effective response rate of 62.5%.

Conclusion

Bleomycin under selected conditions appears to be an excellent therapy for treating soft tissue vascular lesions of low flow nature in craniofacial region. Predictable results were obtained with a high success rate. No systemic or pulmonary complications occurred.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9

Similar content being viewed by others

References

  1. Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 69(3):412–422

    Article  PubMed  CAS  Google Scholar 

  2. Sasaki GH, Pang CY, Wittliff JL (1984) Pathogenesis and treatment of infant skin strawberry hemangiomas: clinical and in vitro studies of hormonal effects. Plast Reconstr Surg 73(3):359–370

    Article  PubMed  CAS  Google Scholar 

  3. Folkman J, Klagsbrun M (1987) Angiogenic factors. Science 235(4787):442–447

    Article  PubMed  CAS  Google Scholar 

  4. Yih WY, Ma GS, Merrill RG, Sperry DW (1989) Central hemangioma of the jaws. J Oral Maxillofac Surg 47(11):1154–1160

    Article  PubMed  CAS  Google Scholar 

  5. Takahashi K, Mulliken JB, Kozakewich HP, Rogers RA, Folkman J, Ezekowitz RA (1994) Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest 93(6):2357–2364

    Article  PubMed  CAS  Google Scholar 

  6. Johnson PL, Eckard DA, Brecheisen MA, Girod DA, Tsue TT (2002) Percutaneous ethanol sclerotherapy of venous malformations of the tongue. AJNR Am J Neuroradiol 23(5):779–782

    PubMed  Google Scholar 

  7. Rahbar R, McGill T, Mulliken J (2005) Vascular tumors and malformations of the head and neck. In: Cummings CW (ed) Otolaryngology-head and neck surgery. Mosby, Philadelphia, pp 4013–4026

    Google Scholar 

  8. Kane WJ, Morris S, Jackson IT et al (1995) Significant hemangiomas and vascular malformations of the head and neck: clinical management and treatment outcomes. Ann Plast Surg 35(2):133–143

    Article  PubMed  CAS  Google Scholar 

  9. O’Donovan JC, Donaldson JS, Morello FP, Pensler JM, Vogelzang RL, Bauer B (1997) Symptomatic hemangiomas and venous malformations in infants, children, and young adults: treatment with percutaneous injection of sodium tetradecyl sulfate. AJR Am J Roentgenol 169(3):723–729

    PubMed  Google Scholar 

  10. Baurmash H, Mandel L (1963) The nonsurgical treatment of hemangioma with Sotradecol. Oral Surg Oral Med Oral Pathol 16:777–782

    Article  PubMed  CAS  Google Scholar 

  11. Minkow B, Laufer D, Gutman D (1979) Treatment of oral hemangiomas with local sclerosing agents. Int J Oral Surg 8(1):18–21

    Article  PubMed  CAS  Google Scholar 

  12. Govrin-Yehudain J, Moscona AR, Calderon N, Hirshowitz B (1987) Treatment of hemangiomas by sclerosing agents: an experimental and clinical study. Ann Plast Surg 18(6):465–469

    Article  PubMed  CAS  Google Scholar 

  13. Baurmash H, DeChiara S (1991) A conservative approach to the management of orofacial vascular lesions in infants and children: report of cases. J Oral Maxillofac Surg 49(11):1222–1225

    Article  PubMed  CAS  Google Scholar 

  14. Khandpur S, Sharma VK (2010) Utility of intralesional sclerotherapy with 3% sodium tetradecyl sulphate in cutaneous vascular malformations. Dermatol Surg 36(3):340–360

    Article  PubMed  CAS  Google Scholar 

  15. Siniluoto TM, Svendsen PA, Wikholm GM, Fogdestam I, Edstrom S (1997) Percutaneous sclerotherapy of venous malformations of the head and neck using sodium tetradecyl sulphate (sotradecol). Scand J Plast Reconstr Surg Hand Surg 31(2):145–150

    Article  PubMed  CAS  Google Scholar 

  16. Legiehn GM, Heran MK (2008) Venous malformations: classification, development, diagnosis, and interventional radiologic management. Radiol Clin North Am 46(3):545–597

    Article  PubMed  Google Scholar 

  17. Acevedo JL, Shah RK, Brietzke SE (2008) Nonsurgical therapies for lymphangiomas: a systematic review. Otolaryngol Head Neck Surg 138(4):418–424

    Article  PubMed  Google Scholar 

  18. Muir T, Kirsten M, Fourie P, Dippenaar N, Ionescu GO (2004) Intralesional bleomycin injection (IBI) treatment for haemangiomas and congenital` vascular malformations. Pediatr Surg Int 12(19):766–773

    Article  Google Scholar 

  19. Zheng JW, Zhang ZY, Zhu HG, Wang YA (2006) Przegląd Flebologiczny 14(5):193–209 © Blackhorse Scientific Publishers, 2006

    Google Scholar 

  20. Spence J, Krings T, terBrugge KG, da Costa LB, Agid R (2010) Interventional percutaneous sclerotherapy for facial venous malformations: subjective clinical and objective MR imaging follow-up results. Am J Neuroradiol 31:955–960

    Article  PubMed  CAS  Google Scholar 

  21. Hou R, Guo J, Hu K, Yang Y, Wang L, Kong L, Liu G, Lei D (2010) A clinical study of ultrasound-guided intralesional injection of bleomycin A5 on venous malformation in cervical-facial region in China. J Vasc Surg 51(4):940–945

    Article  PubMed  Google Scholar 

  22. Sainsbury DCG, Kessell G, Fall AJ, Muir T (2011) Intralesional bleomycin injection treatment for vascular Birthmarks: a 5-year experience at a single United Kingdom Unit. Plast Reconstr Surg 127(5):2031–2044

    Article  PubMed  CAS  Google Scholar 

  23. Fonseca RJ (2000) Oral and maxillofacial surgery, vol 5. Philadelphia, W.B. Saunders Company, p 433

Download references

Author information

Authors and Affiliations

  1. Department of Oral & MaxilloFacial Surgery, Maharanapratap Dental College & Hospital, Flat No. 203, Ashirwad complex, Nawabganj sabji mandi, Kanpur, 208002, India

    Hemant Bajpai

  2. Aanya Dental & Craniofacial Hospital, Kanpur, India

    Sarika Bajpai

Authors
  1. Hemant Bajpai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sarika Bajpai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hemant Bajpai.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bajpai, H., Bajpai, S. Comparative Analysis of Intralesional Sclerotherapy with Sodium Tetradecyl Sulfate Versus Bleomycin in the Management of Low Flow Craniofacial Soft Tissue Vascular Lesions. J. Maxillofac. Oral Surg. 11, 13–20 (2012). https://doi.org/10.1007/s12663-011-0325-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12663-011-0325-7

Keywords

Search

Navigation