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Platelet Concentrates: Past, Present and Future

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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Platelets play a crucial role in hemostasis and wound healing, platelet growth factors are well known source of healing cytokines. Numerous techniques of autologous platelet concentrates have been developed and applied in oral and maxillofacial surgery. This review describes the evolution of the first and second generation of platelet concentrates (platelet rich plasma and platelet rich fibrin respectively) from their fore runner-fibrin sealants.

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References

  1. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e37–e44

    Article  PubMed  Google Scholar 

  2. Gasling VLW, Acil Y, Springer IN, Hubert N, Wiltfag J (2009) Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:45–48

    Article  Google Scholar 

  3. Dohan Ehrenfest DM, Diss A, Odin G, Doglioli P, Hippolyte MP, Charrier JB (2009) In vitro effects of Choukroun’s PRF on human gingival fibroblasts, dermal prekeratinocytes, preadipocytes, and maxillofacial osteoblasts in primary cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108(3):341–352

    Article  PubMed  Google Scholar 

  4. Soffer E, Ouhayoun JP, Anagnostou F (2003) Fibrin sealants and platelet preparations in bone and periodontal healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:521–528

    Article  PubMed  Google Scholar 

  5. Becker W (2008) Fibrin sealants in implant and periodontal treatment: case presentations. Compend Contin Educ Dent 29(3):182–185

    Google Scholar 

  6. Hellem S, Astrand P, Stenstrom B et al (2003) Implant treatment in combination with lateral augmentation of the alveolar process: a 3 year prospective study. Clin Implant Dent Relat Res 5:233–240

    Article  PubMed  Google Scholar 

  7. Trombelli L, Scabbia A, Carotta V et al (1996) Clinical effect of subgingival tetracycline irrigation and tetracycline loaded fiber application in the treatment of adult periodontitis. Quintessence Int 27:19–25

    PubMed  CAS  Google Scholar 

  8. Trombelli L, Scabbia A, Wikesjo UM et al (1996) Fibrin glue application in conjunction with tetracycline root conditioning and coronally positioned flap procedure in the treatment of human gingival recession defects. J Clin Periodontol 23:861–867

    Article  PubMed  CAS  Google Scholar 

  9. Trombelli L, Schincaglia GP, Zangari F et al (1995) Effect of tetracycline HCl conditioning and fibrin-fibronectin system application in the treatment of buccal gingival recession with guided tissue regeneration. A 15 case-report. J Periodontol 66:313–320

    PubMed  CAS  Google Scholar 

  10. Hallman M, Nordin T (2004) Sinus floor augmentation with bovine hydroxyapatite mixed with fibrin glue and later placement of nonsubmerged implants: a retrospective study in 50 patients. Int J Oral Maxillofac Implants 19:222–227

    PubMed  Google Scholar 

  11. Moller JF, Peterson JK (1988) Efficacy of a fibrin sealant on healing of extraction wounds. Int J Oral Maxillofac Implants 17:142–144

    Article  CAS  Google Scholar 

  12. Whitman DH, Berry RL, Green DM (1997) Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg 55:1294–1299

    Article  PubMed  CAS  Google Scholar 

  13. Borzini P, Mazzucco L (2005) Platelet gels and releasates. Curr Opin Hematol 12:473–479

    Article  PubMed  Google Scholar 

  14. Everts PA, Knape JT, Weibrich G, Schonberger JP, Hoffmann J, Overdevest EP et al (2006) Platelet-rich plasma and platelet gel: a review. J Extracorpor Technol 38:174–187

    Google Scholar 

  15. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT (2004) Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 91:4–15

    PubMed  CAS  Google Scholar 

  16. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR (1998) Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 85:638–646

    Article  PubMed  CAS  Google Scholar 

  17. Anitua E, Sanchez M, Orive G, Andia I (2007) The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials 28:4551–4560

    Article  PubMed  CAS  Google Scholar 

  18. Arora NS, Ramanayke T et al (2009) Platelet-rich plasma: a literature review. Implant Dent 18(4):303–308

    Article  PubMed  Google Scholar 

  19. Marx RE (2004) Platelet rich plasma: evidence to support its use. J Oral Maxillofac Surg 64:489–496

    Article  Google Scholar 

  20. Sunitha Raja V, Munirathnam Naidu E (2008) Platelet rich fibrin: evolution of a second generation platelet concentrate. Indian J Dent Res 19:42–46

    Article  PubMed  CAS  Google Scholar 

  21. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e45–e50

    Article  PubMed  Google Scholar 

  22. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e51–e55

    Article  PubMed  Google Scholar 

  23. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL et al (2006) Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101:e56–e60

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Periodontics, College Of Dental Sciences, Room No 4, Davangere, Karnataka, 577004, India

    Shobha Prakash

  2. College Of Dental Sciences, Davangere, Karnataka, 577004, India

    Aditi Thakur

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  1. Shobha Prakash
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  2. Aditi Thakur
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Correspondence to Shobha Prakash.

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Prakash, S., Thakur, A. Platelet Concentrates: Past, Present and Future. J. Maxillofac. Oral Surg. 10, 45–49 (2011). https://doi.org/10.1007/s12663-011-0182-4

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  • DOI: https://doi.org/10.1007/s12663-011-0182-4

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