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Mandibular cystic defect: A composite approach with rhBMP-2 and rib graft

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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Objective

To report treatment of severe mandibular defect caused by Aneurysmal Bone Cyst (ABC) in a 6-year-old child, with off-label use of Recombinant Bone Morphogenetic Protein-2 (rhBMP-2)

Study Design

Clinical Study.

Method

After corrective segmental mandibulectomy, mandible was stabilized by precontoured titanium reconstruction plates spanning the entire defect. After confirming final diagnosis and a wait and watch approach, rhBMP-2 was inserted into mandibular defect along with conventional split rib graft.

Result

New bone formation was identified at 3 months and was evident at radiographic examinations upto 5 months.

Conclusion

Reconstruction of a large mandibular defect was facilitated by use of an osteoinductive factor (rhBMP-2) as a graft additive.

Clinical Relevance

One-step salvage and reconstruction could be facilitated by use of an osteoinductive factor, as a graft additive, may be an alternative strategy for repair of large mandibular defects.

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References

  1. Barnes L, Evenson JW, Reichart P, Sidransky D (2005) World Health Organization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. IARC Press Lyon, 326

  2. Lopez-Arcas Calleja JM, Cebrian Carretero JL, Gonzalez Martin J, Burgueno M (2007) Aneurysmal bone cyst of the mandible: Case presentation and review of the literature. Med Oral Patol Oral Cir Bucal 12(5):E 401–403

    Google Scholar 

  3. Herford AS, Boyne PJ, Williams RP (2007) Clinical Applications of rhBMP-2 in Maxillofacial Surgery. J Calif Dent Assoc 35(5): 335–341

    PubMed  Google Scholar 

  4. Banerjee AR, Westmore GA (1995) Free rib graft reconstruction of the mandible: a forgotten option? Ann R Coll Surg Engl 77(4): 278–282

    PubMed  CAS  Google Scholar 

  5. Stosic S (2008) Mandibular reconstruction state-of-the-art and perspectives. Vojnosanit Pregl 65(5): 397–403

    PubMed  Google Scholar 

  6. Clokie CML, Sandor GKB (2008) Reconstruction of 10 Major Mandibular Defects Using Bioimplants Containing BMP-7. J Can Dent Assoc 74(1): 67–72

    PubMed  Google Scholar 

  7. Derner R, Anderson AC (2005) The Bone Morphogenetic Protein. Clin Podiatr Med Surg 22(4): 607–618

    Article  PubMed  Google Scholar 

  8. Carter TG, Brar PS, Tolas A, Beirne OR (2008) Off-Label Use of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) for Reconstruction of Mandibular Bone Defects in Humans. J Oral Maxillofac Surg 66(7): 1417–1425

    Article  PubMed  Google Scholar 

  9. Chao M, Donovan T, Sotelo C, Carstens MH (2006) In Situ Osteogenesis of Hemimandible with rhBMP-2 in a 9-Year-Old Boy: Osteoinduction Via Stem Cell Concentration. J Craniofac Surg 17(3): 405–412

    Article  PubMed  Google Scholar 

  10. Perri B, Cooper M, Lauryssen C, Anand N (2007) Adverse swelling associated with use of rh-BMP-2 in anterior cervical discectomy and fusion: a case study. Spine J 7(2): 235–239

    Article  PubMed  Google Scholar 

  11. Lu DC, Sun PP (2007) Bone morphogenetic protein for salvage fusion in an infant with Down syndrome and craniovertebral instability. J Neurosurg 106(6 Suppl Pediatrics): 480–483

    PubMed  Google Scholar 

  12. Sucato DJ, Hedequist D, Zhang H, Pierce WA, O’Brien SE, Welch RD (2004) Recombinant human bone morphogenetic protein-2 enhances anterior spinal fusion in a thoracoscopically instrumented animal model. J Bone Joint Surg Am. 86-A(4): 752–762

    PubMed  Google Scholar 

  13. Vukicevic S, Sampath K (2008) Bone Morphogenetic Proteins: From Local to systemic therapeutics. Progress in inflammation Research. Birkhauser Verlag AG. Basel, Switzerland 61: 157–162

    Google Scholar 

  14. Spector DI, Keating JH, Boudrieau RJ. (2007) Immediate Mandibular Reconstruction of a 5 cm Defect Using rhBMP-2 After Partial Mandibulectomy in a Dog. Vet Surg 36(8): 752–759

    PubMed  Google Scholar 

  15. Weiland AJ, Daniel RK, Riley LH Jr (1977) Application of the free vascularized bone graft in the treatment of malignant or aggressive bone tumors. Johns Hopkins Med J 140(3): 85–96

    PubMed  CAS  Google Scholar 

  16. Pramono DC (2004) Spontaneous Bone regeneration after mandible resection in a case of ameloblastoma — A case report. Ann Acad Med Singapore 33(S): 59S–62S

    Google Scholar 

  17. Lane JM, Yasko AW, Tomin E, Cole BJ, Waller S, Browne M, Turek T, Gross J (1999) Bone marrow and recombinant human bone morphogenetic protein-2 in osseous repair. Clin Orthop Relat Res 361: 216–227

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Balaji Dental & Craniofacial Hospital, 30, KB Dasan Road, Teynampet, Chennai-18, India

    S. M. Balaji

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  1. S. M. Balaji
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Correspondence to S. M. Balaji.

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Balaji, S.M. Mandibular cystic defect: A composite approach with rhBMP-2 and rib graft. J. Maxillofac. Oral Surg. 8, 27–30 (2009). https://doi.org/10.1007/s12663-009-0007-x

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  • DOI: https://doi.org/10.1007/s12663-009-0007-x

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