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Effect of Chronic and Subchronic Organic Solvents Exposure on Balance Control of Workers in Plant Manufacturing Adhesive Materials

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Abstract

High-level occupational exposure to volatile organic solvents may elicit neurotoxic effects, especially on central and peripheral structures involved in balance ability. Studies on balance control in relation with exposure levels close to the threshold limit values are scarce. This study aimed to assess the neurotoxic effects of chronic and subchronic exposure to organic solvents among workers in plant manufacturing adhesive materials. Balance control was evaluated in 18 subjects, mainly exposed to n-hexane and toluene, with current median exposure levels of 222 and 102 mg/m3, respectively, and a median exposure duration of 21 years, and in 32 nonexposed controls, using posturography tests with and without sensory conflicting situations. Tests were undergone at the beginning of the work shift (chronic exposure) following a week end, and after 72 h (subchronic exposure). Balance control performance was lower in chronically exposed workers compared to controls, and got worse after subchronic exposure, particularly during situations, where vestibular information was important. Our study suggests that a low-level and prolonged exposure to volatile organic solvents, mainly n-hexane and toluene, in the workplace is associated with deleterious central effects involved in postural regulation. This neurotoxicity is characterized by difficulties to use the most relevant information to control balance, leading to altered management of sensory conflicting situations.

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References

  • Abbate C, Giorgianni C, Munao F (1993) Neurotoxicity induced by exposure to toluene: an electrophysiologic study. Int Arch Occup Environ Health 64:389–392

    Article  PubMed  CAS  Google Scholar 

  • Ameno K, Kiriu T, Fuke C, Ameno S, Shinohara T, Ijiri I (1992) Regional brain distribution of toluene in rats and in human autopsy. Arch Toxicol 66:153–156

    Article  PubMed  CAS  Google Scholar 

  • Andersen I, Lundqvist GR, Mølhave L, Pedersen OF, Proctor DF, Vaeth M, Wyon DP (1983) Human response to controlled levels of toluene in six-hour exposures. Scand J Work Environ Health 9:405–418

    PubMed  CAS  Google Scholar 

  • Arlien-Søborg PA, Zilstorff K, Grandjean B, Milling Pedersen L (1981) Vestibular dysfunction in occupational chronic solvent intoxication. Clin Otolaryngol Allied Sci 6:285–290

    Article  PubMed  Google Scholar 

  • Aydin K, Sencer S, Ogel K, Genchellac H, Demir T, Minareci O (2003) Single-voxel proton MR spectroscopy in toluene abuse. Magn Reson Imaging 21:777–785

    Article  PubMed  Google Scholar 

  • Aylott S, Prasher D (2002) Solvents impair balance in man. Noise Health 4:63–71

    PubMed  Google Scholar 

  • Baelum J (1999) Acute symptoms during non-inhalation exposure to combinations of toluene, trichloroethylene, and n-hexane. Int Arch Occup Environ Health 72:408–410

    Article  PubMed  CAS  Google Scholar 

  • Baker EL (1994) A review of recent research on health effects of human occupational exposure to organic solvents. A critical review. J Occup Med 36:1079–1092

    Article  PubMed  CAS  Google Scholar 

  • Boey KW, Foo SC, Jeyaratnam J (1997) Effects of occupational exposure to toluene: a neuropsychological study on workers in Singapore. Ann Acad Med Singapore 26:84–87

    Google Scholar 

  • Caldemeyer KS, Armstrong SW, George KK, Moran CC, Pascuzzi RM (1996) The spectrum of neuroimaging abnormalities in solvent abuse and their clinical correlation. J Neuroimaging 6:167–173

    PubMed  CAS  Google Scholar 

  • Cardona A, Marhuenda D, Prieto MJ, Martí J, Periago JF, Sánchez JM (1996) Behaviour of urinary 2,5-hexanedione in occupational co-exposure to n-hexane and acetone. Int Arch Occup Environ Health 68:88–93

    PubMed  CAS  Google Scholar 

  • Courtois B (ed) (2008) Aide mémoire technique, ED 984: valeurs limites d'exposition professionnelle aux agents chimiques en France, 2e édition. Editions INRS, Paris, 19 pp

  • Echeverria D, Fine L, Langolf G, Schork A, Sampaio C (1989) Acute neurobehavioural effects of toluene. Br J Ind Med 46:483–495

    PubMed  CAS  Google Scholar 

  • Eller N, Netterstrom B, Laursen P (1999) Risk of chronic effects on the central nervous system at low toluene exposure. Occup Med 49:389–395

    Article  CAS  Google Scholar 

  • Ernstgård L, Gullstrand E, Johanson G, Löf A (1999) Toxicokinetic interactions between orally ingested chlorzoxazone and inhaled acetone or toluene in male volunteers. Toxicol Sci 48:189–196

    Article  PubMed  Google Scholar 

  • Foo SC, Jeyaratnam J, Koh D (1990) Chronic neurobehavioral effects of toluene. Br J Ind Med 47:480–484

    PubMed  CAS  Google Scholar 

  • Gericke C, Hanke B, Beckmann G, Baltes MM, Kühl PK, Neubert D (2001) Multicenter field trial on possible health effects of toluene. III. Evaluation of effects after long-term exposure. Toxicology 168:185–209

    Article  PubMed  CAS  Google Scholar 

  • Herpin G, Gauchard GC, Vouriot A, Hannhart B, Barot A, Mur JM, Zmirou-Navier D, Perrin PP (2008) Impaired neuromotor functions in hospital laboratory workers exposed to low levels of organic solvents. Neurotox Res 13:185–196

    Article  PubMed  CAS  Google Scholar 

  • Herskowitz A, Ishii N, Schaumburg H (1971) N-hexane neuropathy: a syndrome occurring as a result of industrial exposure. N Engl J Med 285:82–85

    Article  PubMed  CAS  Google Scholar 

  • Horak FB, Shupert CL, Mirka A (1989) Components of postural dyscontrol in the elderly: a review. Neurobiol Aging 10:727–738

    Article  PubMed  CAS  Google Scholar 

  • Indulski JA, Sińczuk-Walczak H, Szymczak M, Wesołowski W (1996) Neurological and neurophysiological examinations of workers occupationally exposed to organic solvent mixtures used in the paint and varnish production. Int J Occup Med Environ Health 9:235–244

    PubMed  CAS  Google Scholar 

  • Iwata T, Mori H, Dakeishi M, Onozaki I, Murata K (2005) Effects of mixed organic solvents on neuromotor functions among workers in Buddhist altar manufacturing factories. J Occup Health 47:143–148

    Article  PubMed  CAS  Google Scholar 

  • JORT (Journal Officiel de la République Tunisienne) (1994) Loi n° 94-28, portant régime de réparation des préjudices des accidents du travail et des maladies professionnelles. JORT 15:308–318

    Google Scholar 

  • JORT (Journal Officiel de la République Tunisienne) (1995) Loi n° 95-56, portant régime de réparation des préjudices des accidents du travail et des maladies professionnelles dans le secteur public. JORT 53:1419–1424

    Google Scholar 

  • Kishi R, Harabuchi I, Katakura Y, Ikeda T, Miyake H (1993) Neurobehavioral effects of chronic occupational exposure to organic solvents among Japanese industrial painters. Environ Res 62:303–313

    Article  PubMed  CAS  Google Scholar 

  • Kuo W, Bhattacharya A, Succop P, Linz D (1996) Postural stability assessment in sewer workers. J Occup Environ Med 38:27–34

    Article  PubMed  CAS  Google Scholar 

  • Ledin T, Jansson E, Möller C, Odkvist LM (1991) Chronic toxic encephalopathy investigated using dynamic posturography. Am J Otolaryngol 12:96–100

    Article  PubMed  CAS  Google Scholar 

  • Lee YL, Pai MC, Chen JH, Guo YL (2003) Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure. Occup Med 53:479–482

    Article  CAS  Google Scholar 

  • Lof A, Hjelm EW, Colmsjo A, Lundmark BO, Norström A, Sato A (1993) Toxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8-toluene. Br J Ind Med 50:55–59

    PubMed  CAS  Google Scholar 

  • Magnusson AK, Sulaiman MR, Dutia MB, Tham R (1998) Effects of toluene on tonic firing and membrane properties of rat medial vestibular nucleus neurones in vitro. Brain Res 779:334–337

    Article  PubMed  CAS  Google Scholar 

  • Massion J, Woollacott MH (1996) Posture and equilibrium. In: Bronstein AM, Brandt T, Woollacott M (eds) Balance, posture and gait. Arnold, London, UK, pp 1–18

    Google Scholar 

  • Miyagi Y, Shima F, Ishido K, Yasutake T, Kamikaseda K (1999) Tremor induced by toluene misuse successfully treated by a Vim thalamotomy. J Neurol Neurosurg Psychiatry 66:794–796

    Article  PubMed  CAS  Google Scholar 

  • Mutti A, Ferri F, Lommi G, Lotta S, Lucertini S, Franchini I (1982) n-Hexane-induced changes in nerve conduction velocities and somatosensory evoked potentials. Int Arch Occup Environ Health 51:45–54

    Article  PubMed  CAS  Google Scholar 

  • Nashner LM, Peters JF (1990) Dynamic posturography in the diagnosis and management of dizziness and balance disorders. Neurol Clin 8:331–349

    PubMed  CAS  Google Scholar 

  • Niklasson M, Moller C, Odkvist LM, Ekberg K, Flodin U, Dige N, Skoldestig A (1997) Are deficits in the equilibrium system relevant to the clinical investigation of solvent-induced neurotoxicity? Scand J Work Environ Health 23:206–213

    PubMed  CAS  Google Scholar 

  • Perbellini L, Pezzoli G, Brugnone F, Canesi M (1993) Biochemical and physiological aspects of 2,5-hexanedione: endogenous or exogenous product? Int Arch Occup Environ Health 65:49–52

    Article  PubMed  CAS  Google Scholar 

  • Perrin PhP (2007) Posturographie et vertige positionnel paroxystique bénin. In: Sauvage JP (ed) Rapport de la Société Française d’ORL: vertiges positionnels. Régimédia, Paris, pp 221–226

    Google Scholar 

  • Pryor GT, Rebert CS (1992) Interactive effects of toluene and hexane on behavior and neurophysiologic responses in Fischer-344 rats. Neurotoxicology 13:225–234

    PubMed  CAS  Google Scholar 

  • Ridgway P, Nixon TE, Leach JP (2003) Occupational exposure to organic solvents and long-term nervous system damage detectable by brain imaging, neurophysiology or histopathology. Food Chem Toxicol 41:153–187

    Article  PubMed  CAS  Google Scholar 

  • Roll JP, Roll R (1988) From eye to foot: a proprioceptive chain involved in postural control. In: Amblard B, Berthoz A, Clarac F (eds) Posture and gait: development adaptation and modulation. Elsevier, Amsterdam, pp 155–164

    Google Scholar 

  • Sanagi S, Seki Y, Sugimoto K, Hirata M (1980) Peripheral nervous system functions of workers exposed to n-hexane at a low level. Int Arch Occup Environ Health 47:69–79

    Article  PubMed  CAS  Google Scholar 

  • Shumway-Cook A, Horak F (1986) Assessing the influence of sensory interaction on balance. Phys Ther 66:1548–1550

    PubMed  CAS  Google Scholar 

  • Smith LB, Bhattacharya A, Lemasters G, Succop P, Puhala E, Medvedovic M, Joyce J (1997) Effect of chronic low-level exposure to jet fuel on postural balance of US Air Force personnel. J Occup Environ Med 39:623–632

    Article  PubMed  CAS  Google Scholar 

  • Soulage C, Perrin D, Berenguer P, Pequignot JM (2004) Sub-chronic exposure to toluene at 40 ppm alters the monoamine biosynthesis rate in discrete brain areas. Toxicology 196:21–30

    Article  PubMed  CAS  Google Scholar 

  • Spencer PS, Schaumburg HH, Sabri MI, Veronesi B (1980) The enlarging view of hexacarbon neurotoxicity. CRC Crit Rev Toxicol 17:279–356

    Article  Google Scholar 

  • Sułkowski WJ, Kowalska S, Matyja W, Guzek W, Wesołowski W, Szymczak W, Kostrzewski P (2002) Effects of occupational exposure to a mixture of solvents on the inner ear: a field study. Int J Occup Med Environ Health 15:247–256

    PubMed  Google Scholar 

  • Triolet J (1999) Valeurs limites d’exposition professionnelle aux substances dangereuses. Valeurs de l’ ACGIH (Etats-Unis) et de la Commission MAK (Allemagne). ND 2114-176-99. Cah Notes Doc 176:59–90

    Google Scholar 

  • Vouriot A, Gauchard GC, Chau N, Benamghar L, Lepori ML, Mur JM, PhP Perrin (2004) Sensorial organisation favouring higher visual contribution is a risk factor of falls in an occupational setting. Neurosci Res 48:239–247

    Article  PubMed  Google Scholar 

  • Vouriot A, Gauchard GC, Chau N, Nadif R, Mur JM, PhP Perrin (2005a) Chronic exposure to anesthetic gases affects balance control in operating room personnel. Neurotoxicology 26:193–198

    Article  PubMed  CAS  Google Scholar 

  • Vouriot A, Hannhart B, Gauchard GC, Barot A, Ledin T, Mur JM, PhP Perrin (2005b) Long-term exposure to solvents impairs vigilance and postural control in serigraphy workers. Int Arch Occup Environ Health 78:510–515

    Article  PubMed  CAS  Google Scholar 

  • Vrca A, Bozicevic D, Karacic V (1995) Visual evoked potentials in individuals exposed to long-term low concentrations of toluene. Arch Toxicol 69:337–340

    Article  PubMed  CAS  Google Scholar 

  • White RF, Proctor SP (1997) Solvents and neurotoxicity. Lancet 349:1239–1243

    Article  PubMed  CAS  Google Scholar 

  • Xiao JQ, Levin SM (2000) The diagnosis and management of solvent-related disorders. Am J Ind Med 37:44–61

    Article  PubMed  CAS  Google Scholar 

  • Yokoyama K, Araki S, Murata K, Nishikitani M, Nakaaki K, Yokota J, Ito A, Sakata E (1997) Postural sway frequency analysis in workers exposed to n-hexane, xylene, and toluene: assessment of subclinical cerebellar dysfunction. Environ Res 74:110–115

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. National Institute for Health and Medical Research INSERM U 954, Vandoeuvre-lès-Nancy, France

    Guillaume Herpin, Gérome C. Gauchard, Denis Zmirou-Navier & Philippe P. Perrin

  2. Balance Control & Motor Performance, UFR STAPS, Nancy-University, Villers-lès-Nancy, France

    Guillaume Herpin, Gérome C. Gauchard & Philippe P. Perrin

  3. ENIS, Laboratory “Water, Energy and Environment”, Sfax University, Sfax, Tunisia

    Imed Gargouri, Moncef Khadhraoui & Boubaker Elleuch

  4. Medical School, Laboratory of Occupational Medicine and Occupational Hazards, Lille 2 University, Lille, France

    Imed Gargouri & Catherine Nisse

  5. Department of Occupational Medicine and Professional Pathology, University Hospital Hédi Chaker, Sfax, Tunisia

    Imed Gargouri

  6. Nancy-University Medical School, Vandoeuvre-lès-Nancy, France

    Denis Zmirou-Navier

  7. Department of Oto-Rhino-Laryngology, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France

    Philippe P. Perrin

  8. Equilibration et Performance Motrice, UFR STAPS, Université Henri Poincaré, Nancy Université, 30, rue du Jardin Botanique, Villers-lès-Nancy, 54 600, France

    Philippe P. Perrin

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  1. Guillaume Herpin
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  2. Imed Gargouri
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Correspondence to Philippe P. Perrin.

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Herpin, G., Gargouri, I., Gauchard, G.C. et al. Effect of Chronic and Subchronic Organic Solvents Exposure on Balance Control of Workers in Plant Manufacturing Adhesive Materials. Neurotox Res 15, 179–186 (2009). https://doi.org/10.1007/s12640-009-9018-0

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  • DOI: https://doi.org/10.1007/s12640-009-9018-0

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