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Disubstituted Diaryl Diselenides Inhibit [3H]-Serotonin Uptake in Rats

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Abstract

Diphenyl diselenide (PhSe)2, the parent compound of disubstituted diaryl diselenides, produces significant antidepressant-like effect when evaluated in the forced swimming test (FST) in rats. The goal of this study was to investigate the effects of diphenyl diselenide (PhSe)2, m-trifluoromethyl-diphenyl diselenide (F3CPhSe)2 and p-methoxy-diphenyl diselenide (CH3OPhSe)2 on [3H]-serotonin uptake in rat platelets and synaptosomes. At concentrations higher than 10 μM (PhSe)2, and (F3CPhSe)2 inhibited about 20% [3H]-serotonin uptake in platelets. (CH3OPhSe)2 inhibited [3H]-serotonin uptake in platelets at concentrations higher than 1 μM. Similarly, (PhSe)2, (F3CPhSe)2, and (CH3OPhSe)2 significantly inhibited [3H]-serotonin uptake (about 50%) in synaptosomes from rat brain at concentrations higher than 1 μM. The maximal inhibitory effects of (PhSe)2, (F3CPhSe)2, and (CH3OPhSe)2 on [3H]-serotonin uptake from rat synaptosomes were 65%, 96%, and 80%, respectively. In conclusion, our results demonstrate that disubstituted diaryl diselenides altered monoaminergic system by interacting with monoamine uptake.

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Acknowledgments

The financial support by UFSM, FAPERGS, CAPES, and CNPq is gratefully acknowledged. C. W. Nogueira is the recipient of CNPq fellowship.

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Authors and Affiliations

  1. Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, CEP 97105-900, Brazil

    V. C. Borges, L. Savegnago, G. Dadalt & Cristina Wayne Nogueira

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  1. V. C. Borges
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  2. L. Savegnago
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  3. G. Dadalt
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  4. Cristina Wayne Nogueira
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Correspondence to Cristina Wayne Nogueira.

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Borges, V.C., Savegnago, L., Dadalt, G. et al. Disubstituted Diaryl Diselenides Inhibit [3H]-Serotonin Uptake in Rats. Neurotox Res 15, 57–61 (2009). https://doi.org/10.1007/s12640-009-9005-5

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  • DOI: https://doi.org/10.1007/s12640-009-9005-5

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