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Silicatein-Mediated Polycondensation of Orthosilicic Acid: Modeling of a Catalytic Mechanism Involving Ring Formation

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Abstract

The sponge protein silicatein is the first enzyme that has been described to form an inorganic polymer (silica) from a monomeric precursor (tetraethoxysilane or orthosilicic acid). The models proposed for silicatein-mediated silica formation are mainly based on the use of synthetic substrates (hydrolytic cleavage of tetraethoxysilane to silanol compounds) or only consider the formation of less reactive silicic acid dimers (disilicic acid). Here we propose a new model for the catalytic mechanism of silicatein that leads to the formation of reactive, cyclic silicic acid species (trisiloxane rings and higher-membered siloxane rings) which easily promote the silica polycondensation reaction.

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Authors and Affiliations

  1. Institute for Physiological Chemistry, University Medical Center of Johannes Gutenberg University Mainz, Duesbergweg 6, 55128, Mainz, Germany

    Heinz C. Schröder, Matthias Wiens, Ute Schloßmacher, David Brandt & Werner E. G. Müller

Authors
  1. Heinz C. Schröder
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  2. Matthias Wiens
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  3. Ute Schloßmacher
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  4. David Brandt
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  5. Werner E. G. Müller
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Corresponding authors

Correspondence to Heinz C. Schröder or Werner E. G. Müller.

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Schröder, H.C., Wiens, M., Schloßmacher, U. et al. Silicatein-Mediated Polycondensation of Orthosilicic Acid: Modeling of a Catalytic Mechanism Involving Ring Formation. Silicon 4, 33–38 (2012). https://doi.org/10.1007/s12633-010-9057-4

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  • DOI: https://doi.org/10.1007/s12633-010-9057-4

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