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Factors Contributing to Late-Stage Breast Cancer Presentation in sub-Saharan Africa

  • Global Breast Cancer (BO Anderson and C Duggan, Section Editors)
  • Published:
Current Breast Cancer Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Late stage at breast cancer diagnosis is a major contributor to poor survival from breast cancer in many sub-Saharan African countries. Using Ugandan as an example, we discuss barriers along the journey to diagnosis and highlight areas where improvements are needed.

Recent Findings

In Uganda, the majority of breast cancer patients noticed symptoms of their cancer for at least 9 months prior to diagnosis, which is typical of many African countries. For most women, the health provider delay is extensive, owing to barriers related to cost, transport, stigma, provider knowledge, and difficult-to-navigate referral systems.

Summary

Downstaging efforts should focus on reducing health system delay and target low community awareness. Implementation research to strengthen women’s breast cancer knowledge, access to breast health services, and referral pathways provide clear opportunities for downstaging.

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References

  1. The World Bank. World Bank Open Data. 2018 [cited 2018 April 2]; Available from: https://data.worldbank.org/region/sub-saharan-africa?view=chart.

  2. Dingemanse M. Spoken languages of African countries—Nations Online Project. 2018 [cited 2018 March 27]; Available from: http://www.nationsonline.org/oneworld/african_languages.htm.

  3. Jones-Hepler B, Moran K, Griffin J, McClure EM, Rouse D, Barbosa C, et al. Maternal and Neonatal Directed Assessment of Technologies (MANDATE): methods and assumptions for a predictive model for maternal, fetal, and neonatal mortality interventions. Glob Health Sci Pract. 2017;5(4):571–80.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Kawooya MG, Nathan RO, Swanson J, Swanson DL, Namulema E, Ankunda R, et al. Impact of introducing routine antenatal ultrasound services on reproductive health indicators in Mpigi District, Central Uganda. Ultrasound Q. 2015;31(4):285–9.

    Article  PubMed  Google Scholar 

  5. Nathan R, Swanson JO, Marks W, Goldsmith N, Vance C, Sserwanga NB, et al. Screening obstetric ultrasound training for a 5-country cluster randomized controlled trial. Ultrasound Q. 2014;30(4):262–6.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Swanson JO, Kawooya MG, Swanson DL, Hippe DS, Dungu-Matovu P, Nathan R. The diagnostic impact of limited, screening obstetric ultrasound when performed by midwives in rural Uganda. J Perinatol. 2014;34(7):508–12.

    Article  PubMed  CAS  Google Scholar 

  7. Rice B, Boulle A, Baral S, Egger M, Mee P, Fearon E, et al. Strengthening routine data systems to track the HIV epidemic and guide the response in sub-Saharan Africa. JMIR Public Health Surveill. 2018;4(2):e36.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Lessler J, Moore SM, Luquero FJ, McKay HS, Grais R, Henkens M, et al. Mapping the burden of cholera in sub-Saharan Africa and implications for control: an analysis of data across geographical scales. Lancet. 2018;391:1908–15.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Bor J, Herbst AJ, Newell ML, Barnighausen T. Increases in adult life expectancy in rural South Africa: valuing the scale-up of HIV treatment. Science. 2013;339(6122):961–5.

    Article  PubMed  CAS  Google Scholar 

  10. Espina C, McKenzie F, Dos-Santos-Silva I. Delayed presentation and diagnosis of breast cancer in African women: a systematic review. Ann Epidemiol. 2017;27(10):659–71 e7.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Ginsburg O, Bray F, Coleman MP, Vanderpuye V, Eniu A, Kotha SR, et al. The global burden of women’s cancers: a grand challenge in global health. Lancet. 2017;389(10071):847–60.

    Article  PubMed  Google Scholar 

  12. Global Burden of Disease Cancer C, Fitzmaurice C, Dicker D, et al. The global burden of cancer 2013. JAMA Oncol. 2015;1(4):505–27.

    Article  Google Scholar 

  13. International Agency for Research on Cancer. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. 2012 [cited 2018 March 27]; Available from: http://globocan.iarc.fr/Pages/DataSource_and_methods.aspx.

  14. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.

    Article  PubMed  Google Scholar 

  15. Allemani C, Matsuda T, Di Carlo V, et al. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391(10125):1023–75.

    Article  PubMed  Google Scholar 

  16. Allemani C, Weir HK, Carreira H, Harewood R, Spika D, Wang XS, et al. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet. 2015;385(9972):977–1010.

    Article  PubMed  Google Scholar 

  17. Kingham TP, Alatise OI, Vanderpuye V, Casper C, Abantanga FA, Kamara TB, et al. Treatment of cancer in sub-Saharan Africa. Lancet Oncol. 2013;14(4):e158–67.

    Article  PubMed  Google Scholar 

  18. Meacham E, Orem J, Nakigudde G, Zujewski JA, Rao D. Exploring stigma as a barrier to cancer service engagement with breast cancer survivors in Kampala, Uganda. Psychooncology. 2016;25(10):1206–11.

    Article  PubMed  Google Scholar 

  19. Hayes Constant TK, Winkler JL, Bishop A, Taboada Palomino LG. Perilous uncertainty: situating women’s breast-health seeking in northern Peru. Qual Health Res. 2014;24(6):811–23.

    Article  PubMed  Google Scholar 

  20. McKenzie F, Zietsman A, Galukande M, Anele A, Adisa C, Parham G, et al. Drivers of advanced stage at breast cancer diagnosis in the multicountry African breast cancer—disparities in outcomes (ABC-DO) study. Int J Cancer. 2018;142(8):1568–79.

    Article  PubMed  CAS  Google Scholar 

  21. Jedy-Agba E, McCormack V, Adebamowo C, Dos-Santos-Silva I. Stage at diagnosis of breast cancer in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Glob Health. 2016;4(12):e923–e35.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Wabinga HR, Nambooze S, Amulen PM, Okello C, Mbus L, Parkin DM. Trends in the incidence of cancer in Kampala, Uganda 1991-2010. Int J Cancer. 2014;135(2):432–9.

    Article  PubMed  CAS  Google Scholar 

  23. Galukande M, Kiguli-Malwadde E. Rethinking breast cancer screening strategies in resource-limited settings. Afr Health Sci. 2010;10(1):89–92.

    PubMed  PubMed Central  CAS  Google Scholar 

  24. Monu JU, Muyinda Z, Taljanovic M. ISS outreach sub-Saharan Africa insight: Uganda 2011. Skelet Radiol. 2012;41(11):1347–8.

    Article  Google Scholar 

  25. Ministry of Health. Cobalt-60 radiotherapy machine installed—radiotherapy services restored at Uganda Cancer Institute Republic of Uganda 2018 [cited 2018 March 27]; Available from: http://health.go.ug/content/cobalt-60-radiotherapy-machine-installed-–-radiotherapy-services-restored-uganda-cancer.

  26. Weedon-Fekjaer H, Lindqvist BH, Vatten LJ, Aalen OO, Tretli S. Breast cancer tumor growth estimated through mammography screening data. Breast Cancer Res. 2008;10(3):R41.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Galukande M, Mirembe F, Wabinga H. Patient delay in accessing breast cancer care in a sub Saharan African country: Uganda. Br J Med Med Res. 2014;4(13):2599–610.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Atuhairwe C, Amongin D, Agaba E, Mugarura S, Taremwa IM. The effect of knowledge on uptake of breast cancer prevention modalities among women in Kyadondo County, Uganda. BMC Public Health. 2018;18(1):279.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Muthoni A, Miller AN. An exploration of rural and urban Kenyan women’s knowledge and attitudes regarding breast cancer and breast cancer early detection measures. Health Care Women Int. 2010;31(9):801–16.

    Article  PubMed  Google Scholar 

  30. Scheel JR, Molina Y, Anderson BO, Patrick DL, Nakigudde G, Gralow JR, et al. Breast cancer beliefs as potential targets for breast cancer awareness efforts to decrease late-stage presentation in Uganda. Journal of Global Oncology. 2018; https://doi.org/10.1200/JGO.2016.008748.

  31. Koon KP, Lehman CD, Gralow JR. The importance of survivors and partners in improving breast cancer outcomes in Uganda. Breast. 2013;22(2):138–41.

    Article  PubMed  Google Scholar 

  32. Scheel JR, Nealey EM, Orem J, Bugeza S, Muyinda Z, Nathan RO, et al. ACR BI-RADS use in low-income countries: an analysis of diagnostic breast ultrasound practice in Uganda. J Am Coll Radiol. 2016;13(2):163–9.

    Article  PubMed  Google Scholar 

  33. Gakwaya A, Galukande M, Luwaga A, Jombwe J, Fualal J, Kiguli-Malwadde E, et al. Breast cancer guidelines for Uganda (2nd edition 2008). Afr Health Sci. 2008;8(2):126–32.

    PubMed  PubMed Central  CAS  Google Scholar 

  34. Scheel JR, Molina Y, Patrick DL, Anderson BO, Nakigudde G, Lehman CD, et al. Breast cancer downstaging practices and breast health messaging preferences among a community sample of urban and rural Ugandan women. J Glob Oncol. 2017;3(2):105–13.

    Article  PubMed  Google Scholar 

  35. Scheel JR, Peacock S, Orem J, Bugeza S, Muyinda Z, Porter PL, et al. Improving breast ultrasound interpretation in Uganda using a condensed breast imaging reporting and data system. Acad Radiol. 2016;23(10):1271–7.

    Article  PubMed  Google Scholar 

  36. Lauby-Secretan B, Scoccianti C, Loomis D, Benbrahim-Tallaa L, Bouvard V, Bianchini F, et al. Breast-cancer screening—viewpoint of the IARC Working Group. N Engl J Med. 2015;372(24):2353–8.

    Article  PubMed  CAS  Google Scholar 

  37. Romanoff A, Constant TH, Johnson KM, Guadiamos MC, Vega AMB, Zunt J, et al. Association of previous clinical breast examination with reduced delays and earlier-stage breast cancer diagnosis among women in Peru. JAMA Oncol. 2017;3(11):1563–7.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Scheel JR, Molina Y, Coronado G, Bishop S, Doty S, Jimenez R, et al. Healthcare factors for obtaining a mammogram in Latinas with a variable mammography history. Oncol Nurs Forum. 2017;44(1):66–76.

    Article  PubMed  PubMed Central  Google Scholar 

  39. International Agency for Research on Cancer. Breast cancer screening. Lyon: IARC; 2014.

    Google Scholar 

  40. Yip CH, Smith RA, Anderson BO, Miller AB, Thomas DB, Ang E, et al. Guideline implementation for breast healthcare in low- and middle-income countries: early detection resource allocation. Cancer. 2009;113(8 Suppl):2244–56.

    Google Scholar 

  41. McTiernan A. Guideline implementation for breast healthcare in low- and middle-income countries. Cancer. 2008;113(S8):2244–56.

    Article  PubMed  Google Scholar 

  42. Mwebembezi E. Uganda commemorates World Cancer Day 2018. World Health Organisation; 2018 [cited 2018 March 27]; Available from: http://www.afro.who.int/news/uganda-commemorates-world-cancer-day-2018.

  43. Kangmennaang J, Mkandawire P, Luginaah I. Breast cancer screening among women in Namibia: explaining the effect of health insurance coverage and access to information on screening behaviours. Glob Health Promot. 2017; https://doi.org/10.1177/1757975917727017.

  44. Schwartz JI, Guwatudde D, Nugent R, Kiiza CM. Looking at non-communicable diseases in Uganda through a local lens: an analysis using locally derived data. Glob Health. 2014;10:77.

    Article  Google Scholar 

  45. Essue BM, Kapiriri L. The unfunded priorities: an evaluation of priority setting for noncommunicable disease control in Uganda. Glob Health. 2018;14(1):22.

    Article  Google Scholar 

  46. Nakigudde G. The Uganda Women’s Cancer Support Organisation: About Us. 2017 [cited 2018 March 27]; Available from: http://uwocaso.org.ug/about-us/.

  47. Ali N, Njeri A, Ssembatya R, Matovu A, Streeter M, DeStigter K. Using village health teams to disseminate ultrasound education in rural Uganda. JGR. 2015;1(2)

  48. Lukong KE, Ogunbolude Y, Kamdem JP. Breast cancer in Africa: prevalence, treatment options, herbal medicines, and socioeconomic determinants. Breast Cancer Res Treat. 2017;166(2):351–65.

    Article  PubMed  Google Scholar 

  49. Hulett JM, Armer JM, Stewart BR, Wanchai A. Perspectives of the breast cancer survivorship continuum: diagnosis through 30 months post-treatment. J Pers Med. 2015;5(2):174–90.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Matovu A, Scheel JR, Galukande M, DeStigter KK. Implementation of a resource-appropriate strategy for downstaging breast cancer in rural Uganda. JGR. 2016;2(1):1–6.

    Article  Google Scholar 

  51. Vanderpuye V, Grover S, Hammad N, PoojaPrabhakar, Simonds H, Olopade F, et al. An update on the management of breast cancer in Africa. Infect Agent Cancer. 2017;12:13.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  52. World Health Organization. Task shifting: global recommendations and guidelines. 2008 [cited 2018 March 28]; Available from: http://www.who.int/workforcealliance/knowledge/resources/taskshifting_guidelines/en/.

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Correspondence to John R. Scheel.

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The authors declare that they have no competing interests.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Global Breast Cancer

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Scheel, J.R., Anderson, S., Foerster, M. et al. Factors Contributing to Late-Stage Breast Cancer Presentation in sub-Saharan Africa. Curr Breast Cancer Rep 10, 142–147 (2018). https://doi.org/10.1007/s12609-018-0278-7

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  • DOI: https://doi.org/10.1007/s12609-018-0278-7

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