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Therapeutic and Nutritional Effects of Synbiotic Yogurts in Children and Adults: a Clinical Review

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Abstract

Synbiotic yogurts (SYs) are potential natural cures with improved health outcomes and prevention and control of chronic diseases through the synergistic action of probiotic bacteria and prebiotic compounds. Recent clinical achievements in consuming SYs in healthy and patient pediatric and adult populations were critically reviewed. Some forthcoming challenges and interesting solutions to increase healthy nutritional effects of these dairy products have also been addressed. The use of SY-based nutrition pattern in children can considerably increase their body’s immunity with an improvement in social and school functioning. SY consumption not only reduces childhood digestive problems but also remarkably decreases the illness duration and symptoms’ severity. Increasing the number of bifidobacteria and lactobacilli in gastrointestinal (GI) tract of healthy adults consuming SYs can significantly reduce the pathogenic bacteria in feces. The regular intake of SYs with enhanced bioavailability of bioactive compounds in a short intestinal transit time reduces the risk of cardiovascular disease among hypercholesterolemic adults. Also, a meaningful improvement in the health status of adult patients with irritable bowel syndrome and nonalcoholic fatty liver disease has been assessed after eating this bio-functional supplement product. Administration of a healthy SY-based diet purposefully alters microbiota composition, provides a microbial balance in the gut, and promotes GI functions in pediatric and geriatric age groups. Full recovery without any further complications during the follow-up period in elderly patients can also be obtained by implementing the SY-based dietary guideline.

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Abbreviations

SY:

Synbiotic yogurt

sIgA:

Secretory immunoglobulin A

SCFAs:

Short-chain fatty acids

FOS:

Fructooligosaccharide

XOS:

Xylooligosaccharide

HDL-C:

High-density lipoprotein cholesterol

LDL-C:

Low-density lipoprotein cholesterol

CVDs:

Cardiovascular diseases

T2DM:

Type 2 diabetes mellitus

FC:

Functional constipation

ITT:

Intestinal transit time

GI:

Gastrointestinal

GALT:

Gut-associated lymphoid tissue

IBS:

Irritable bowel syndrome

IBD:

Inflammatory bowel disease

MS:

Metabolic syndrome

MHC:

Moderately hypercholesterolemic

NAFLD:

Nonalcoholic fatty liver disease

References

  1. Bakhshimoghaddam F, Shateri K, Sina M, Hashemian M, Alizadeh M (2018) Daily consumption of synbiotic yogurt decreases liver steatosis in patients with nonalcoholic fatty liver disease: a randomized controlled clinical trial. J Nutr 148(8):1276–1284

    Article  PubMed  Google Scholar 

  2. Sivieri K, Freire FC, Lopes NP, Shiraishi CT, Pires AC, Lima AC, Zavarizi AC, Sgarbosa L, Bianchi F (2017) Synbiotic yogurts and the elderly. In: Shah NP (ed) Yogurt in health and disease prevention. Academic Press, pp. 259-271

  3. Mojtahedi SY, Izadi A, Seirafi G, Khedmat L, Tavakolizadeh R (2018) Risk factors associated with neonatal jaundice: a cross-sectional study from Iran. Open Access Maced J Med Sci 6(8):1387–1393

    Article  PubMed  PubMed Central  Google Scholar 

  4. Mojtahedi SY, Rahbarimanesh A, Khedmat L, Izadi A (2018) The prevalence of risk factors for the development of bacteraemia in children. Open access Maced J Med Sci 6(11):2023–2029

    Article  PubMed  PubMed Central  Google Scholar 

  5. Fazilah NF, Ariff AB, Khayat ME, Rios-Solis L, Halim M (2018) Influence of probiotics, prebiotics, synbiotics and bioactive phytochemicals on the formulation of functional yogurt. J Funct Foods 48:387–399

    Article  CAS  Google Scholar 

  6. Salari M, Razavi SH, Gharibzahedi SM (2014) Characterising the synbiotic beverages based on barley and malt flours fermented by Lactobacillus delbrueckii and paracasei strains. Qual Assur Saf Crop Food 7(3):355–361

    Article  CAS  Google Scholar 

  7. Shokoohi M, Razavi SH, Labbafi M, Vahidinia A, Gharibzahedi SMT (2014) Wheat sprout flour as an attractive substrate for the producing probiotic fermented beverages: process development and product characterisation. Qual Assur Saf Crop Food 7(4):469–475

    Article  CAS  Google Scholar 

  8. Sah BN, Vasiljevic T, McKechnie S, Donkor ON (2016) Antioxidant peptides isolated from synbiotic yoghurt exhibit antiproliferative activities against HT-29 colon cancer cells. Int Dairy J 63:99–106

    Article  CAS  Google Scholar 

  9. O’Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K (2005) Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 128:541–551

    Article  PubMed  Google Scholar 

  10. Baştürk A, Artan R, Yilmaz A (2016) Efficacy of synbiotic, probiotic, and prebiotic treatments for irritable bowel syndrome in children: a randomized controlled trial. Turk J Gastroenterol 27:439–443

    Article  PubMed  Google Scholar 

  11. Noorbakhsh H, Yavarmanesh M, Mortazavi SA, Adibi P, Moazzami AA (2018) Metabolomics analysis revealed metabolic changes in patients with diarrhea-predominant irritable bowel syndrome and metabolic responses to a synbiotic yogurt intervention. Eur J Nutr 3:1–10

    Google Scholar 

  12. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V (2012) Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition 28(5):539–543

    Article  PubMed  CAS  Google Scholar 

  13. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V, Akbarian-Moghari A (2011) Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci 94(7):3288–3294

    Article  PubMed  CAS  Google Scholar 

  14. Asemi Z, Jazayeri S, Najafi M, Samimi M, Mofid V, Shidfar F, Shakeri H, Esmaillzadeh A (2012) Effect of daily consumption of probiotic yogurt on oxidative stress in pregnant women: a randomized controlled clinical trial. Ann Nutr Metab 60(1):62–68

    Article  PubMed  CAS  Google Scholar 

  15. Irvine SL, Hekmat S (2011) Evaluation of sensory properties of probiotic yogurt containing food products with prebiotic fibres in Mwanza, Tanzania. Food Nutr Sci 2(5):434–439

    CAS  Google Scholar 

  16. Falke S (2015) Development of a synbiotic drinkable yogurt for school-aged children. In: Doctoral dissertation, Kansas State University

  17. Ladjevardi ZS, Gharibzahedi SM, Mousavi M (2015) Development of a stable low-fat yogurt gel using functionality of psyllium (Plantago ovata Forsk) husk gum. Carbohydr Polym 125:272–280

    Article  PubMed  CAS  Google Scholar 

  18. Gharibzahedi SM, Chronakis IS (2018) Crosslinking of milk proteins by microbial transglutaminase: utilization in functional yogurt products. Food Chem 245:620–632

    Article  PubMed  CAS  Google Scholar 

  19. Lestari LA, Setyabudi FS, Julia M, dan Amalia LD (2003) Effect of synbiotic yogurt made with indigenous probiotic Lactobacillus plantarum MUT7 and sweet potato fiber (Ipomoea batatas) in healthy children. Int Res J Microbiol 4(3):98–102

  20. Matijašić BB, Obermajer T, Lipoglavšek L, Sernel T, Locatelli I, Kos M, Šmid A, Rogelj I (2016) Effects of synbiotic fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis ssp. lactis BB-12 on the fecal microbiota of adults with irritable bowel syndrome: a randomized double-blind, placebo-controlled trial. J Dairy Sci 99(7):5008–5021

    Article  CAS  Google Scholar 

  21. Mohammadi-Sartang M, Bellissima N, de Zepetnek JT, Brett NR, Mazloomi SM, Fararouie M, Bedeltavana A, Famouri M, Mazloom Z (2018) The effect of daily fortified yogurt consumption on weight loss in adults with metabolic syndrome: a 10-week randomized controlled trial. Nutr Metab Cardiovasc Dis 28(6):565–574

    Article  PubMed  CAS  Google Scholar 

  22. Miremadi F, Sherkat F, Stojanovska L (2017) Health promoting effect of synbiotic yogurt containing pomegranate polyphenols: scientific evidence. Maturitas 100:141

    Article  Google Scholar 

  23. Corrêa-Oliveira R, Fachi JL, Vieira A, Sato FT, Vinolo MA (2016) Regulation of immune cell function by short-chain fatty acids. Clin Transl Immunol 5(4):e73

    Article  CAS  Google Scholar 

  24. Hussein L, Gouda M, Fouad M, Labib E, Bassyouni R, Mohammad M (2014) Dietary intervention with yoghurt, synbiotic yogurt or traditional fermented Sobya: bio-potency among male adolescents using five bio-markers of relevance to colonic metabolic activities. Food Nutr Sci 5(12):1131–1144

    CAS  Google Scholar 

  25. Ringel-Kulka T, Kotch JB, Jensen ET, Savage E, Weber DJ (2015) Randomized, double-blind, placebo-controlled study of synbiotic yogurt effect on the health of children. J Pediatr 166:1475–1481

    Article  PubMed  Google Scholar 

  26. Vandenplas Y (2015) Synbiotic yogurt consumption leads to statistical improvements in child health that may not be clinically relevant. BMJ Evid-Based Med 20(6):207

    Article  Google Scholar 

  27. Ringel-Kulka T, Palsson OS, Maier D, Ringel Y (2008) Yogurt containing the probiotic bacteria Bifidobacterium lactis BB12 and prebiotic inulin significantly improves of colonic transit time in subjects with functional bowel symptoms. Am J Gastroenterol 103:S479

    Article  Google Scholar 

  28. Binns CW, Lee AH, Harding H, Gracey M, Barclay DV (2007) The CUPDAY study: prebiotic-probiotic milk product in 1–3-year-old children attending childcare centres. Acta Paediatr 96(11):1646–1650

    Article  PubMed  CAS  Google Scholar 

  29. Malpeli A, Gonzalez SN, Vicentin D, Apas AL, González HF (2012) Randomised, double-blind and placebo-controlled study of the effect of a synbiotic dairy product on orocecal transit time in healthy adult women. Nutr Hosp 27(4):1314–1319

    PubMed  CAS  Google Scholar 

  30. Marteau P, Boutron-Ruault MC (2002) Nutritional advantages of probiotics and prebiotics. Br J Nutr 87(Suppl. 2):S153–S157

    Article  PubMed  CAS  Google Scholar 

  31. Tulk HM, Blonski DC, Murch LA, Duncan AM, Wright AJ (2013) Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults. Nutr J 12(1):87

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  32. Rahbarimanesh A, Mojtahedi SY, Sadeghi P, Ghodsi M, Kianfar S, Khedmat L, Siyahkali SJ, Yazdi MK, Izadi A (2019) Antimicrobial stewardship program (ASP): an effective implementing technique for the therapy efficiency of meropenem and vancomycin antibiotics in Iranian pediatric patients. Ann Clin Microbiol Antimicrob 18(1):6

    Article  PubMed  PubMed Central  Google Scholar 

  33. Palaia A, Johnson-Kanda I, O’Sullivan DJ (2012) Effect of a synbiotic yogurt on levels of fecal Bifidobacteria, Clostridia, and Enterobacteria. Appl Environ Microbiol 78(4):933–940

    Article  CAS  Google Scholar 

  34. Komprda T, Sládková P, Kolářová M, Zorníková G, Sládek Z, Rožnovská D (2013) Effect of probiotic and symbiotic yoghurt consumption on counts of human faecal bacteria and tyramine production. J Food Nutr Res 52(4):230–238

    CAS  Google Scholar 

  35. Granata M, Brandi G, Borsari A, Gasbarri R, Gioia DD (2013) Synbiotic yogurt consumption by healthy adults and the elderly: the fate of bifidobacteria and LGG probiotic strain. Int J Food Sci Nutr 64(2):162–168

    Article  PubMed  CAS  Google Scholar 

  36. Lyte M (2004) The biogenic amine tyramine modulates the adherence of Escherichia coli O157:H7 to intestinal mucosa. J Food Prot 67:878–883

    Article  PubMed  CAS  Google Scholar 

  37. Timan P, Ramanathan N, Manroot M, Sandee C, Teekachunhatean S (2014) Effect of synbiotic fermented milk on oral bioavailability of isoflavones in postmenopausal women. Int J Food Sci Nutr 65(6):761–767

    Article  PubMed  CAS  Google Scholar 

  38. Kießling G, Schneider J, Jahreis G (2002) Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol. Eur J Clin Nutr 56(9):843–849

    Article  PubMed  CAS  Google Scholar 

  39. Gmeiner M, Kneifel W, Kulbe KD, Wouters R, De Boever P, Nollet L, Verstraete W (2000) Influence of a synbiotic mixture consisting of Lactobacillus acidophilus 74-2 and a fructooligosaccharide preparation on the microbial ecology sustained in a simulation of the human intestinal microbial ecosystem (SHIME reactor). Appl Microbiol Biotechnol 53:219–223

    Article  PubMed  CAS  Google Scholar 

  40. Heap S, Ingram J, Law M, Tucker AJ, Wright AJ (2016) Eight-day consumption of inulin added to a yogurt breakfast lowers postprandial appetite ratings but not energy intakes in young healthy females: a randomised controlled trial. Brit J Nutr 115(2):262–270

    Article  PubMed  CAS  Google Scholar 

  41. Eslamparast T, Zamani F, Hekmatdoost A, Sharafkhah M, Eghtesad S, Malekzadeh R, Poustchi H (2014) Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study. Br J Nutr 112(3):438–445

    Article  PubMed  CAS  Google Scholar 

  42. Mallappa RH, Rokana N, Duary RK, Panwar H, Batish VK, Grover S (2012) Management of metabolic syndrome through probiotic and prebiotic interventions. Indian J Endocrinol Metab 16(1):20–27

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  43. Perumpail BJ, Li AA, John N, Sallam S, Shah ND, Kwong W, Cholankeril G, Kim D, Ahmed A (2019) The therapeutic implications of the gut microbiome and probiotics in patients with NAFLD. Diseases 7(1):27

    Article  PubMed Central  CAS  Google Scholar 

  44. Sengupta S, Koley H, Dutta S, Bhowal J (2019) Hepatoprotective effects of synbiotic soy yogurt on mice fed on high cholesterol diet. Nutrition 63-64:36–44

    Article  PubMed  CAS  Google Scholar 

  45. Octavia ZF, Djamiatun K, Suci N (2017) Pengaruh pemberian yogurt sinbiotik tepung pisang tanduk terhadap profil lipid tikus sindrom metabolik. J Gizi Klinik Indones 13(4):159–169

    Article  Google Scholar 

  46. Moroti C, Magri LF, de Rezende CM, Cavallini DC, Sivieri K (2012) Effect of the consumption of a new symbiotic shake on glycemia and cholesterol levels in elderly people with type 2 diabetes mellitus. Lipids Health Dis 11(1):29

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  47. De Paula JA, Carmuega E, Weill R (2008) Effect of the ingestion of a symbiotic yogurt on the bowel habits of women with functional constipation. Acta Gastroenterol Latinoam 38(1):16–25

    PubMed  Google Scholar 

  48. Rahmawati FC, Djamiatun K, Suci N (2017) Pengaruh yogurt sinbiotik pisang terhadap kadar glukosa dan insulin tikus sindrom metabolik. J Gizi Klinik Indones 14(1):10–18

    Article  Google Scholar 

  49. Mathews S (2017) Efficacy of microencapsulation on synbiotic yogurt production. University Grants Commission, New Delhi, India

    Google Scholar 

  50. Van De Wiele T, Boon N, Possemiers S, Jacobs H, Verstraete W (2007) Inulin-type fructans of longer degree of polymerization exert more pronounced in vitro prebiotic effects. J Appl Microbiol 102(2):452–460

    PubMed  Google Scholar 

  51. Li Y, Shabani KI, Qin X, Yang R, Jin X, Ma X, Liu X (2019) Effects of cross-linked inulin with different polymerisation degrees on physicochemical and sensory properties of set-style yoghurt. Int Dairy J 94:46–52

    Article  CAS  Google Scholar 

  52. White J, Hekmat S (2018) Development of probiotic fruit juices using Lactobacillus rhamnosus GR-1 fortified with short chain and long chain inulin fiber. Fermentation 4(2):27

    Article  CAS  Google Scholar 

  53. Van Loo J (2004) The specificity of the interaction with intestinal bacterial fermentation by prebiotics determines their physiological efficacy. Nutr Res Rev 17(1):89–98

    PubMed  Google Scholar 

  54. Flores Gallegos AC, Sánchez-Picazo BO, Ilina A, Rodríguez-Jasso RM, Aguilar CN (2019) Production of an enzymatic extract from Aspergillus oryzae DIA-MF to improve the fructooligosaccharides profile of aguamiel. Front Nutr 6:15

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Food Science and Technology, Faculty of Nutrition Science & Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Vahid Mofid

  2. Department of Pediatric Infection Disease, Tehran University of Medical Sciences, Tehran, Iran

    Anahita Izadi

  3. Department of Pediatric Nephrology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Sayed Yousef Mojtahedi

  4. Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Leila Khedmat

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  1. Vahid Mofid
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  2. Anahita Izadi
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  3. Sayed Yousef Mojtahedi
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  4. Leila Khedmat
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Correspondence to Leila Khedmat.

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Mofid, V., Izadi, A., Mojtahedi, S.Y. et al. Therapeutic and Nutritional Effects of Synbiotic Yogurts in Children and Adults: a Clinical Review. Probiotics & Antimicro. Prot. 12, 851–859 (2020). https://doi.org/10.1007/s12602-019-09594-x

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