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Effect of Different Concentrations of Bacillus subtilis on Immune Response of Broiler Chickens

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Abstract

This trial was conducted to study the effects of different Bacillus subtilis concentrations on immune response of broiler chickens. There were 5 treatment groups: control, with no added B. subtilis supplementation, and 4 treatment groups receiving feed supplemented with different concentrations of B. subtilis. The trial was conducted with 225 broilers. The weight of broiler chickens in all groups receiving feed supplemented with B. subtilis was significantly higher and the feed conversion was better independently of the concentration than that of the control chickens. The degree of diffuse lymphohistiocytic infiltration and the number of solitary lymphoid follicles in the mucosa increased in accordance with the B. subtilis concentration of the feed. The birds from the groups fed B. subtilis-supplemented diets had significantly increased antibody responses to vaccination against Newcastle disease virus. The appearance of increased diffuse lymphohistiocytic infiltration and solitary lymphoid follicles in the mucosa and a stronger response to NDV indicate increased immunological response in chickens fed with a B. subtilis-supplemented diet.

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Acknowledgments

We would like to acknowledge the financial support of Chr. Hansen A/S, Denmark. The authors express their sincere thanks to Merete Moerk Jensen, Chr. Hansen, to Károly Kustos, Lab-Nyúl Kft. and to Lídia Lennert, Research Institute of Animal Breeding and Nutrition, for the performance of this trial and to Dr. Chris Morrow, Bioproperties, for the contributions and suggestions.

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Authors and Affiliations

  1. Division of Small Animal Research, Institute for Small Animal Research and Co-ordination Centre of Gene Conservation, Isaszegi u. 200, 2100, Gödöllő, Hungary

    A. Kőrösi Molnár, B. Podmaniczky, Gy. Virág, Zs. Szabó & Zs. Farkas

  2. SMV-Probiotics, Copenhagen, Denmark

    P. Kürti

  3. Department of Histology, Veterinary Diagnostic Directorate, Budapest, Hungary

    R. Glávits

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  1. A. Kőrösi Molnár
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  2. B. Podmaniczky
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  3. P. Kürti
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  5. Gy. Virág
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  6. Zs. Szabó
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Correspondence to A. Kőrösi Molnár.

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Kőrösi Molnár, A., Podmaniczky, B., Kürti, P. et al. Effect of Different Concentrations of Bacillus subtilis on Immune Response of Broiler Chickens. Probiotics & Antimicro. Prot. 3, 8–14 (2011). https://doi.org/10.1007/s12602-011-9063-x

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