Abstract
Lipid droplets (LDs) are ubiquitous organelles that store and supply lipids to regulate cellular lipid homeostasis. Fatty acids are packaged as triglyceride and cholesterol ester into endoplasmic reticulum (ER) membranes to synthesize LDs. Cytosolic LDs move dynamically and interact with organelles, including other LDs. In this process, functional proteins for metabolism are also transferred to LDs. In this review, I focus on interactions between the ER and LDs related to lipid metabolism.
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Bickel PE, Tansey JT, Welte MA (2009) PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta 1791(6):419–440. http://www.ncbi.nlm.nih.gov/pubmed/19375517. Accessed 4 Sep 2016
Choudhary V et al (2015) A conserved family of proteins facilitates nascent lipid droplet budding from the ER. J Cell Biol 211(2):261–71. http://www.ncbi.nlm.nih.gov/pubmed/26504167. Accessed 4 Sep 2016
Copeland DE, Dalton AJ (1959) An association between mitochondria and the endoplasmic reticulum in cells of the pseudobranch gland of a teleost. J Biophys Biochem Cytol 5(3):393–396. http://www.ncbi.nlm.nih.gov/pubmed/13664679. Accessed 4 Sep 2016
Gross DA, Zhan C, Silver DL (2011) Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation. Proc Natl Acad Sci USA 108(49):19581–19586. http://www.ncbi.nlm.nih.gov/pubmed/22106267. Accessed 4 Sep 2016
Guo Y et al (2008) Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453(7195):657–661. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2734507&tool=pmcentrez&rendertype=abstract. Accessed 5 Aug 2011
Imai N et al (2015) Hepatocyte-specific depletion of ubxd8 induces periportal steatosis in mice fed a high-fat diet. PloS One 10(5):e0127114. http://www.ncbi.nlm.nih.gov/pubmed/25970332. Accessed 4 Sep 2016
Kadereit B et al (2008) Evolutionarily conserved gene family important for fat storage. Proc Natl Acad Sci USA 105(1):94–99. http://www.ncbi.nlm.nih.gov/pubmed/18160536. Accessed 4 Sep 2016
Kassan A et al (2013) Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains. J Cell Biol 203(6):985–1001. http://www.ncbi.nlm.nih.gov/pubmed/24368806. Accessed 4 Sep 2016
Kory N, Farese RV, Walther TC (2016) Targeting fat: mechanisms of protein localization to lipid droplets. Trends Cell Biol 26(7):535–546. http://www.ncbi.nlm.nih.gov/pubmed/26995697. Accessed 4 Sep 2016
López-Crisosto C et al (2015) ER-to-mitochondria miscommunication and metabolic diseases. Biochim Biophys Acta 1852(10 Pt A):2096–2105. http://www.ncbi.nlm.nih.gov/pubmed/26171812. Accessed 4 Sep 2016
Miranda DA et al (2014) Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue. J Biol Chem 289(14):9560–9572. http://www.ncbi.nlm.nih.gov/pubmed/24519944. Accessed 4 Sep 2016
Ohsaki Y et al (2006) Cytoplasmic lipid droplets are sites of convergence of proteasomal and autophagic degradation of apolipoprotein B. Mol Biol Cell 17(6):2674–2683. http://www.ncbi.nlm.nih.gov/pubmed/16597703. Accessed 4 Sep 2016
Ohsaki Y et al (2008) Lipid droplets are arrested in the ER membrane by tight binding of lipidated apolipoprotein B-100. J Cell Sci 121(Pt 14):2415–2422. http://www.ncbi.nlm.nih.gov/pubmed/18577578. Accessed 12 Aug 2011
Reue K, Zhang P (2008) The lipin protein family: dual roles in lipid biosynthesis and gene expression. FEBS Lett 582(1):90–96. http://www.ncbi.nlm.nih.gov/pubmed/18023282. Accessed 4 Sep 2016
Sim MFM et al (2012) The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1. Mol Metab 2(1):38–46. http://www.ncbi.nlm.nih.gov/pubmed/24024128. Accessed 4 Sep 2016
Soni KG et al (2009) Coatomer-dependent protein delivery to lipid droplets. J Cell Sci 122(Pt 11):1834–1841. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2684835&tool=pmcentrez&rendertype=abstract. Accessed 29 Sep 2011
Suzuki M et al (2012) Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets. Mol Biol Cell 23(5):800–810. http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3290640&tool=pmcentrez&rendertype=abstract. Accessed 7 Mar 2012
Suzuki M et al (2015) ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment. Mol Biol Cell 26(12):2333–2342. http://www.ncbi.nlm.nih.gov/pubmed/25904333. Accessed 4 Sep 2016
Tauchi-Sato K et al (2002) The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J Biol Chem 277(46):44507–44512. http://www.ncbi.nlm.nih.gov/pubmed/12221100. Accessed 4 Jun 2016
Thiam AR et al (2013) COPI buds 60-nm lipid droplets from reconstituted water–phospholipid–triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci USA 110(33):13244–13249. http://www.ncbi.nlm.nih.gov/pubmed/23901109. Accessed 4 Sep 2016
Wang C-W, Miao Y-H, Chang Y-S (2014) Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16. J Cell Sci 127(Pt 6):1214–1228. http://www.ncbi.nlm.nih.gov/pubmed/24434579. Accessed 4 Sep 2016
Wilfling F et al (2014) Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting. Elife 3:e01607. http://www.ncbi.nlm.nih.gov/pubmed/24497546. Accessed 4 Sep 2016
Acknowledgements
I deeply thank Dr. Toyoshi Fujimoto (Nagoya University) for his assistance and mentorship.
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Suzuki, M. Regulation of lipid metabolism via a connection between the endoplasmic reticulum and lipid droplets. Anat Sci Int 92, 50–54 (2017). https://doi.org/10.1007/s12565-016-0378-2
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DOI: https://doi.org/10.1007/s12565-016-0378-2