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Promising antidiabetic potential of fucoxanthin isolated from the edible brown algae Eisenia bicyclis and Undaria pinnatifida

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  • Food Science and Technology
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Abstract

In the present study, we investigated the antidiabetic potential of fucoxanthin via the inhibition of rat lens aldose reductase (RLAR), human recombinant aldose reductase (HRAR), advanced glycation end-product (AGE) formation, protein tyrosine phosphatase 1B (PTP1B), and α-glucosidase. Fucoxanthin displayed potent inhibitory activity against AGE formation and HRAR and RLAR activity. In addition, fucoxanthin showed potent inhibitory activity against PTP1B. However, it did not show α-glucosidase inhibitory activity below 200 μM. In addition, our kinetic study revealed that fucoxanthin competitively inhibited RLAR, while it showed mixed-type inhibition against PTP1B. In order to confirm enzyme inhibition, we predicted the 3D structure of PTP1B using Autodock 4.0 to simulate the binding of fucoxanthin. Docking simulation results demonstrated that three residues of PTP1B (Phe30, Phe52, and Gly183) interact with the two hydroxyl groups of fucoxanthin. In addition, the binding energy was negative (−7.66 kcal/mol), indicating that the three hydrogen bonds may stabilize the open form of the enzyme and potentiate tighter binding to the active site of PTP1B, resulting in more effective PTP1B inhibition. The results of the present study therefore clearly demonstrate the promising potential of fucoxanthin as a therapeutic intervention for the management of diabetes as well as diabetes-associated complications, which could be explored further.

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Acknowledgments

This work was financially supported by the Ministry of Food, Agriculture, Forestry and Fisheries (20111001212-00) in the Republic of Korea.

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Authors and Affiliations

  1. Department of Food Science and Human Nutrition, and Research Institute of Human Ecology, Chonbuk National University, Jeonju, 561-756, Republic of Korea

    Hyun Ah Jung

  2. Department of Food Science and Nutrition, Pukyong National University, Busan, 608-737, Republic of Korea

    Md. Nurul Islam, Chan Mee Lee & Jae Sue Choi

  3. College of Pharmacy, Pusan National University, Busan, 609-735, Republic of Korea

    Hyong Oh Jeong & Hae Young Chung

  4. Division of Applied Chemical Engineering, Pukyong National University, Busan, 608-739, Republic of Korea

    Hee Chul Woo

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  1. Hyun Ah Jung
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  2. Md. Nurul Islam
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Correspondence to Jae Sue Choi.

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Jung, H.A., Islam, M.N., Lee, C.M. et al. Promising antidiabetic potential of fucoxanthin isolated from the edible brown algae Eisenia bicyclis and Undaria pinnatifida . Fish Sci 78, 1321–1329 (2012). https://doi.org/10.1007/s12562-012-0552-y

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  • DOI: https://doi.org/10.1007/s12562-012-0552-y

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