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Cofilin and profilin: partners in cancer aggressiveness

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Abstract

This review covers aspects of cofilin and profilin regulations and their influence on actin polymerisation responsible for cell motility and metastasis. The regulation of their activity by phosphorylation and nitration, miRs, PI(4,5)P2 binding, pH, oxidative stress and post-translational modification is described. In this review, we have highlighted selected similarities, complementarities and differences between the two proteins and how their interplay affects actin filament dynamics.

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Authors and Affiliations

  1. School of Rural Medicine, University of New England, Armidale, Australia

    Joelle V. F. Coumans

  2. Centre for Bioactive Discovery in Health and Ageing, School of Science and Technology, University of New England, Armidale, Australia

    Rhonda J. Davey & Pierre D. J. Moens

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  1. Joelle V. F. Coumans
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Joelle VF Coumans declares that she has no conflicts of interest. Rhonda J Davey declares that she has no conflicts of interest. Pierre DJ Moens declares that he has no conflicts of interest.

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Joelle V. F. Coumans and Rhonda J. Davey have participated equally in the writing of this review.

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Coumans, J.V.F., Davey, R.J. & Moens, P.D.J. Cofilin and profilin: partners in cancer aggressiveness. Biophys Rev 10, 1323–1335 (2018). https://doi.org/10.1007/s12551-018-0445-0

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