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PI2PE: a suite of web servers for predictions ranging from protein structure to binding kinetics

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Abstract

PI2PE (http://pipe.sc.fsu.edu) is a suite of four web servers for predicting a variety of folding- and binding-related properties of proteins. These include the solvent accessibility of amino acids upon protein folding, the amino acids forming the interfaces of protein–protein and protein–nucleic acid complexes, and the binding rate constants of these complexes. Three of the servers debuted in 2007, and have garnered ∼2,500 unique users and finished over 30,000 jobs. The functionalities of these servers are now enhanced, and a new sever, for predicting the binding rate constants, has been added. Together, these web servers form a pipeline from protein sequence to tertiary structure, then to quaternary structure, and finally to binding kinetics.

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Acknowledgment

We acknowledge the staff at the Florida State University High-Performance Computing Facility for assistance. This work was supported in part by Grant GM58187 from the National Institutes of Health.

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  1. Department of Physics and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL, 32306, USA

    Sanbo Qin & Huan-Xiang Zhou

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  1. Sanbo Qin
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  2. Huan-Xiang Zhou
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Correspondence to Sanbo Qin or Huan-Xiang Zhou.

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Qin, S., Zhou, HX. PI2PE: a suite of web servers for predictions ranging from protein structure to binding kinetics. Biophys Rev 5, 41–46 (2013). https://doi.org/10.1007/s12551-012-0086-7

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