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SH3 domains: modules of protein–protein interactions

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Abstract

Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.

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Abbreviations

Ack-1:

Activated CDC42-associated kinase

Csk:

Carboxyl-terminal Src kinase

Fyn:

FGR and yes-related novel kinase

Hck:

Hematopoetic cell kinase

IB1:

Islet brain 1

PEP:

Proline-enriched phosphatase

PEST:

Proline/glutamic acid/serine/threonine-rich domain

PTK:

Protein tyrosine kinase

SH3:

Src homology 3

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Authors and Affiliations

  1. Department of Biophysics, The School of Theoretical Modeling, PO Box 15676, Chevy Chase, MD, 20825, USA

    Natalya Kurochkina

  2. Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm 13 N240-C 10, Center Drive, Bethesda, MD, 20892, USA

    Udayan Guha

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  1. Natalya Kurochkina
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  2. Udayan Guha
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Correspondence to Natalya Kurochkina.

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Kurochkina, N., Guha, U. SH3 domains: modules of protein–protein interactions. Biophys Rev 5, 29–39 (2013). https://doi.org/10.1007/s12551-012-0081-z

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  • DOI: https://doi.org/10.1007/s12551-012-0081-z

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