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Dental pulp regeneration

In vitro and in vivo approaches

  • review
  • Published:
international journal of stomatology & occlusion medicine

Abstract

Trauma in the oral region and tooth avulsion are a major part of injuries in children, adolescents, and young adults. Established methods used to manage these cases provide mainly repair, but not regeneration. Tissue engineering paves the way for research in the new field of regenerative endodontics to overcome the limits of conservative strategies. This review aims to provide an overview of the available in vitro and in vivo models for dental pulp regeneration. The review covers different in vitro models, including two- and three-dimensional models and organ cultures, comprising both ectopic and orthotopic approaches. These models show the great potential of tissue engineering for regenerative endodontics, which can lead to regeneration of the pulp–dentin complex in future.

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Acknowledgments

The authors acknowledge that their research on prolyl hydroxylase inhibitors was funded by Grant RCL 653 from the International Team for Implantology (Basel, Switzerland), Grant 10-063 of the Osteology Foundation (Lucerne, Switzerland), and the Erwin Schrödinger Fellowship the Austrian Science Fund (FWF): J3379-B19. We thank Sylvia Nürnberger (Department of Trauma Surgery, Medical University of Vienna, Vienna; Austrian Cluster for Tissue Regeneration, Vienna, Austria; Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria) for performing the histology and Heinz-Dieter Müller (Department of Prosthodontics, Medical University of Vienna, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria; Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Bern, Switzerland) for image preparation.

Conflict of interest

K. Janjić, B. Cvikl, A. Moritz, and H. Agis state that there are no conflicts of interest. The accompanying manuscript does not include studies on humans or animals.

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Authors and Affiliations

  1. Department of Conservative Dentistry and Periodontology, Medical University of Vienna, Sensengasse 2a, 1090, Vienna, Austria

    Klara Janjić, Barbara Cvikl, Andreas Moritz & Hermann Agis

  2. Austrian Cluster for Tissue Regeneration, Vienna, Austria

    Klara Janjić, Barbara Cvikl, Andreas Moritz & Hermann Agis

  3. Department of Preventive, Restorative and Pediatric Dentistry, University of Bern, Bern, Switzerland

    Barbara Cvikl

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  1. Klara Janjić
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  2. Barbara Cvikl
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Correspondence to Hermann Agis.

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Janjić, K., Cvikl, B., Moritz, A. et al. Dental pulp regeneration. J. Stomat. Occ. Med. 8 (Suppl 1), 1–9 (2016). https://doi.org/10.1007/s12548-015-0139-1

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