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Risk factors for infantile hemangioma: a meta-analysis

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Abstract

Background

Infantile hemangioma (IH) is one of the most common tumors in infants. Its pathogenesis is complex and poorly understood. The risk factors of IH have been extensively studied from clinical and epidemiological perspectives in recent years, but the conclusions in the literature reports are inconsistent. To provide a reference for the prevention of hemangioma, we conducted a meta-analysis of the published studies of potential risk factors for IH.

Methods

The Cochrane Library, Ovid, PubMed, and Web of Science databases were searched systematically. Log odds ratios (log ORs), logistic regression standard errors and 95% confidence intervals (CIs) were used to compare the correlation between IH and potential risk factors. Review Manager 5.3.3 was used for the statistical analysis.

Results

Six studies were included and 17 potential risk factors were eventually evaluated. P values < 0.05 were found for female gender (P < 0.01, OR 2.04, 95% CI 1.65–2.51), low birth weight (P < 0.01, OR 4.39, 95% CI 3.05–6.31), multiple gestation (P = 0.01, OR 2.39, 95% CI 1.21–4.71), preterm birth (P = 0.03, OR 2.37, 95% CI 1.07–5.23), progesterone therapy (P < 0.01, OR 2.73, 95% CI 2.12–3.51), and family history (P = 0.01, OR 1.98, 95% CI 1.16–3.38).

Conclusions

This meta-analysis revealed that risk factors, including female gender, low birth weight, multiple gestation, preterm birth, progesterone therapy, and family history may affect the occurrence of IH.

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Funding

This study was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (2019D01C128).

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Authors and Affiliations

  1. Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830000, China

    Yuan Ding, Jing-Zhan Zhang, Shi-Rong Yu, Fang Xiang & Xiao-Jing Kang

Authors
  1. Yuan Ding
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  2. Jing-Zhan Zhang
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  3. Shi-Rong Yu
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  4. Fang Xiang
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  5. Xiao-Jing Kang
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Contributions

YD conceptualized and designed this study, designed the data collection instruments, collected data, carried out the initial analysis, drafted the initial manuscript, and reviewed and revised the manuscript. JZZ collected data, carried out the initial analyses, and reviewed and revised the manuscript. YD and JZZ contributed equally to this work. SRY, FX, and XJK conceptualized and designed the study, coordinated and supervised data collection and critically reviewed the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

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Correspondence to Xiao-Jing Kang.

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The authors declare that they have no competing interests. No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

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Ding, Y., Zhang, JZ., Yu, SR. et al. Risk factors for infantile hemangioma: a meta-analysis. World J Pediatr 16, 377–384 (2020). https://doi.org/10.1007/s12519-019-00327-2

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  • DOI: https://doi.org/10.1007/s12519-019-00327-2

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