Skip to main content
SpringerLink
Log in

Twelve-year prevalence of common neonatal congenital malformations in Zhejiang Province, China

  • Original Article
  • Published:
World Journal of Pediatrics Aims and scope Submit manuscript

Abstract

Background

One of the challenges that pediatricians face when examining birth defects is to understand the trends in its occurrence and provide clues to etiology. This study was undertaken to retrospectively assess the prevalence of 10 common neonatal congenital malformations by reviewing a database of all deliveries from 28 weeks up until 7 days of birth from January 1998 to December 2009 in Zhejiang Province, China.

Methods

Ten common neonatal congenital malformations were selected for analysis. The incidence and the Cochran-Armitage Trend were assessed via SAS9.2. A P value ≤0.05 was considered statistically significant.

Results

Of 83 888 perinatals, 374 (4.46‰) suffered from congenital heart diseases (CHD), 77 (0.92‰) from congenital hydrocephalus, 32 (0.38‰) from intestinal atresia/stenosis, 36 (0.43‰) from anorectal malformations, 149 (1.78‰) from kidney malformations, 139 (3.31‰) from hypospadias (male), 178 (2.12‰) from orofacial clefts (OFC), 188 (2.24‰) from polydactyly, 62 (0.74‰) from syndactyly, and 269 (3.21‰) from accessory auricle anomaly. Their trend of prevalence varied as follows: CHD, P=0.0026; hydrocephalus, P=0.0042; intestinal atresia/stenosis, P=0.0103; anorectal malformations, P=0.4332; kidney malformations, P<0.0001; hypospadias, P=0.0021; OFC, P=0.005; polydactyly, P=0.0867; syndactyly, P=0.1941; and accessory auricle anomaly, P=0.0011. The upward trend was as follows: CHD (P=0.0026), intestinal atresia/stenosis (P=0.0103), kidney malformations (P<0.0001), hypospadias (P=0.0021), OFC (P=0.005), and accessory auricle anomaly (P=0.0011). The incidence of hydrocephalus (P=0.0042) showed a downward trend. No statistical significant trend was found in anorectal malformations (P=0.4332), polydactyly (P=0.0867) and syndactyly (P=0.1941).

Conclusions

The incidences of CHD, intestinal atresia/stenosis, kidney malformations, hypospadias, OFC, and accessory auricle anomaly have increased in the last 12 years, but the incidences of anorectal malformations, polydactyly and syndactyly remain stable. The incidence of hydrocephalus shows a downward trend.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Romitti PA. Utility of family history reports of major birth defects as a public health strategy. Pediatrics 2007;120Suppl 2:S71–77.

    Article  PubMed  Google Scholar 

  2. Zhang JZ, Pan SC, Huang CR, eds. Practical Pediatric Surgery, 1st ed. Hang Zhou: Zhejiang Technology Press, 2003.

    Google Scholar 

  3. Bird TM, Hobbs CA, Cleves MA, Tilford JM, Robbins JM. National rates of birth defects among hospitalized newborns. Birth Defects Res A Clin Mol Teratol 2006;76:762–769.

    Article  PubMed  CAS  Google Scholar 

  4. Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A. Prevalence of congenital heart defects in Metropolitan Atlanta, 1998–2005. J Pediatr 2008;153:807–813.

    Article  PubMed  Google Scholar 

  5. Botto LD, Correa A, Erickson JD. Racial and temporal variations in the prevalence of heart defects. Pediatrics 2001;107:E32.

    Article  PubMed  CAS  Google Scholar 

  6. Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890–1900.

    Article  PubMed  Google Scholar 

  7. Li Z, Ren A, Zhang L, Ye R, Li S, Zheng J, et al. Extremely high prevalence of neural tube defects in a 4-county area in Shanxi Province, China. Birth Defects Res A Clin Mol Teratol 2006;76:237–240.

    Article  PubMed  CAS  Google Scholar 

  8. Dai L, Zhou GX, Miao L, Zhu J, Wang YP, Liang J. Prevalence analysis on congenital hydrocephalus in Chinese perinatal from 1996 to 2004. Zhonghua Yu Fang Yi Xue Za Zhi 2006;40:180–183. [in Chinese]

    PubMed  Google Scholar 

  9. Stevenson RE, Allen WP, Pai GS, Best R, Seaver LH, Dean J, et al. Decline in prevalence of neural tube defects in a high-risk region of the United States. Pediatrics 2000;106:677–683.

    Article  PubMed  CAS  Google Scholar 

  10. Brouwers MM, Feitz WF, Roelofs LA, Kiemeney LA, de Gier RP, Roeleveld N. Risk factors for hypospadias. Eur J Pediatr 2007;166:671–678.

    Article  PubMed  Google Scholar 

  11. Abdullah NA, Pearce MS, Parker L, Wilkinson JR, Jaffray B, McNally RJ. Birth prevalence of cryptorchidism and hypospadias in northern England, 1993–2000. Arch Dis Child 2007;92:576–579.

    Article  PubMed  CAS  Google Scholar 

  12. Paulozzi LJ, Erickson JD, Jackson RJ. Hypospadias trends in two US surveillance systems. Pediatrics 1997;100:831–834.

    Article  PubMed  CAS  Google Scholar 

  13. Chong JH, Wee CK, Ho SK, Chan DK. Factors associated with hypospadias in Asian newborn babies. J Perinat Med 2006;34:497–500.

    Article  PubMed  Google Scholar 

  14. Baskin LS, Ebbers MB. Hypospadias: anatomy, etiology, and technique. J Pediatr Surg 2006;41:463–472.

    Article  PubMed  Google Scholar 

  15. Hussain N, Chaghtai A, Herndon CD, Herson VC, Rosenkrantz TS, McKenna PH. Hypospadias and early gestation growth restriction in infants. Pediatrics 2002;109:473–478.

    Article  PubMed  Google Scholar 

  16. Lee RS, Cendron M, Kinnamon DD, Nguyen HT. Antenatal hydronephrosis as a predictor of postnatal outcome: a metaanalysis. Pediatrics 2006;118:586–593.

    Article  PubMed  Google Scholar 

  17. Lowry RB, Sibbald B, Bedard T. Stability of prevalence rates of anorectal malformations in the Alberta Congenital Anomalies Surveillance System 1990-2004. J Pediatr Surg 2007;42:1417–1421.

    Article  PubMed  Google Scholar 

  18. Cuschieri A. Descriptive epidemiology of isolated anal anomalies: a survey of 4.6 million births in Europe. Am J Med Genet 2001;103:207–215.

    Article  PubMed  CAS  Google Scholar 

  19. Cuschieri A; EUROCAT Working Group. Anorectal anomalies associated with or as part of other anomalies. Am J Med Genet 2002;110:122–130.

    Article  PubMed  Google Scholar 

  20. Myers MF, Li S, Correa-Villaseñor A, Li Z, Moore CA, Hong SX. Folic acid supplementation and risk for imperforate anus in China. Am J Epidemiol 2001;154:1051–1056.

    Article  PubMed  CAS  Google Scholar 

  21. Koga Y, Hayashida Y, Ikeda K, Inokuchi K, Hashimoto N. Intestinal atresia in fetal dogs produced by localized ligation of mesenteric vessels. J Pediatr Surg 1975;10:949–953.

    Article  PubMed  CAS  Google Scholar 

  22. Acs N, Bánhidy F, Puhó EH, Czeizel AE. A possible association between maternal glomerulonephritis and congenital intestinal atresia/stenosis—a population-based case-control study. Eur J Epidemiol 2007;22:557–564.

    Article  PubMed  Google Scholar 

  23. Liang J, Wang YP, Miao L. Epidemiology study on the congenital intestinal atresia/stenosis in Chinese perinatals. Matern Child Health Care China 2000;15:252–253. [in Chinese]

    Google Scholar 

  24. Gregg TA, Leonard AG, Hayden C, Howard KE, Coyle CF. Birth prevalence of cleft lip and palate in Northern Ireland (1981 to 2000). Cleft Palate Craniofac J 2008;45:141–147.

    Article  PubMed  CAS  Google Scholar 

  25. Li Z, Ren A, Liu J, Zhang L, Ye R, Li S, et al. High prevalence of orofacial clefts in Shanxi Province in northern China, 2003–2004. Am J Med Genet A 2008;146A:2637–2643.

    Article  PubMed  Google Scholar 

  26. González BS, López ML, Rico MA, Garduño F. Oral clefts: a retrospective study of prevalence and predisposal factors in the State of Mexico. J Oral Sci 2008;50:123–129.

    Article  PubMed  Google Scholar 

  27. Zhou GX, Dai L, Zhu J, Miao L, Wang YP, Liang J, et al. Epidemiological analysis of polydactylies in Chinese perinatals. Sichuan Da Xue Xue Bao Yi Xue Ban 2004;35:708–710. [in Chinese]

    PubMed  Google Scholar 

  28. Beder LB, Kemaloğlu YK, Maral I, Serdaroğlu A, Bumin MA. A study on the prevalence of accessory auricle anomaly in Turkey. Int J Pediatr Otorhinolaryngol 2002;63:25–27.

    Article  PubMed  CAS  Google Scholar 

  29. Gao JZ, Chen YM, Gao YP. A survey of accessory auricle anomaly. Pedigree analysis of seven cases. Arch Otolaryngol Head Neck Surg 1990;116:1194–1196.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Neonatal Intensive Care Unit, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China

    Ge Sun

  2. Department of Urology, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Zhe-Ming Xu & Da-Xing Tang

  3. Department of Information, Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Jian-Feng Liang

  4. Department of Women’s Health Care, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Lin Li

Authors
  1. Ge Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhe-Ming Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jian-Feng Liang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lin Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Da-Xing Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ge Sun.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sun, G., Xu, ZM., Liang, JF. et al. Twelve-year prevalence of common neonatal congenital malformations in Zhejiang Province, China. World J Pediatr 7, 331–336 (2011). https://doi.org/10.1007/s12519-011-0328-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12519-011-0328-y

Key words

Search

Navigation