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Ethnicity differences in plasma apoC-III levels between African American and Caucasian youths

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Abstract

Background

Little is known about the association between apoC-III and lipoprotein-lipids in African American (AA) and Caucasian (CA) youths. The aim of this study was to investigate if plasma apoC-III level is associated with ethnicity differences in atherogenic lipoprotein-lipids between AA and CA youths.

Methods

A total of 202 youths (mean age 16.1±1.3 y, range 13.8–18.9 y) consisting of 122 AA (boys/girls, 52/70) and 80 CA (boys/girls, 40/40) youths were recruited via flyers sent to local high schools. For AA youths, body mass index (BMI) values were 22.5±5.0 kg/m2 and 25.0±6.8 kg/m2 for boys and girls, respectively. For CA youths, BMI values were 22.0±4.8 kg/m2 and 22.1±5.0 kg/m2 for boys and girls, respectively. Anthropometric variables were measured using standard procedures. Body fat was measured by dual-energy X-ray absorptiometry. Fasting glucose and insulin, lipoprotein-lipids, and apolipoproteins were measured in fasting plasma samples.

Results

AA youths had significantly lower values in apoC-III (P<0.001), triglyceride (P<0.001), and total cholesterol/high-density lipoprotein cholesterol (P=0.011) and higher values in HDLC (P=0.004), apoE (P=0.016), insulin (P=0.027), and homoeostasis model of assessmentinsulin resistance (HOMA-IR) (P=0.025) than CA youths. Body composition and insulin resistance parameters were significantly associated with apoC-III levels in CA youths, but not in AA youths. Regression analyses showed that waist circumference and HOMA-IR were significant predictors for apoC-III in CA, not AA, youths.

Conclusions

The findings of the current study suggest that ethnicity differences in atherogenic lipids between AA and CA youths may be associated with differences in apoC-III and apoE levels.

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Authors and Affiliations

  1. Division of Humanities and Social Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea

    Ji-Young Lee

  2. School of Sports Science, Sungkyunkwan University, Suwon, Republic of Korea

    Hye-Ryun Hong & Hyun-Sik Kang

  3. School of Sports Science, Sungkyunkwan University, 300 Chenchen-dong, Jangan-gu, Suwon, Republic of Korea

    Hyun-Sik Kang

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  1. Ji-Young Lee
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Correspondence to Hyun-Sik Kang.

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Lee, JY., Hong, HR. & Kang, HS. Ethnicity differences in plasma apoC-III levels between African American and Caucasian youths. World J Pediatr 7, 136–142 (2011). https://doi.org/10.1007/s12519-011-0266-8

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