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Functional gastrointestinal disorders: past and present

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Abstract

Background

Chronic abdominal pain is a common complaint in childhood and adolescence. Despite decades of clinical observations and research, it still poses a challenge to pediatric health care professionals. The aim of this review is to highlight the epidemiology of pediatric chronic abdominal pain and to describe the pathogenesis of this disorder, its clinical manifestations, evaluation and therapeutic options.

Data sources

Articles on chronic abdominal pain in the recent years from PubMed, MEDLINE, and reference textbooks were reviewed.

Results

Chronic abdominal pain, a functional gastrointestinal disorder (FGID), is a multifactorial condition that results from a complex interaction between psychosocial and physiologic factors via the brain-gut axis. A thorough history coupled with a complete physical examination and normal screening studies rule out an organic cause in 95% of the cases. It is highly important for the physician to establish a trusting relationship with the child and parents because successful treatment including modification of physical and psychological stress factors, dietary changes, and drug therapy depends greatly on education, reassurance and active psychological support.

Conclusions

FGIDs are a cause of great anxiety, distress and morbidity in children as well as adults. As our understanding of these conditions improves, our therapeutic interventions will progress not only to overcome them but also to intervene early in the disease course so as to limit long-term impact.

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References

  1. Croffie JM, Fitzgerald JF, Chong SK. Recurrent abdominal pain in children—a retrospective study of outcome in a group referred to a pediatric gastroenterology practice. Clin Pediatr (Phila) 2000;39:267–274.

    CAS  Google Scholar 

  2. El-Matary W, Spray C, Sandhu B. Irritable bowel syndrome: the commonest cause of recurrent abdominal pain in children. Eur J Pediatr 2004;163:584–588.

    Article  PubMed  Google Scholar 

  3. Apley J. The child with abdominal pains, 2nd ed. London: Blackwell, 1975.

    Google Scholar 

  4. Apley J, Hale B. Children with recurrent abdominal pain: how do they grow up? Br Med J 1973;7:7–9.

    Article  Google Scholar 

  5. Apley J, Naish N. Recurrent abdominal pains: a field survey of 1,000 school children. Arch Dis Child 1958;33:165–170.

    Article  PubMed  CAS  Google Scholar 

  6. Rasquin-Weber A, Hyman P, Cucchiara S, Fleisher D, Hyams J, Milla P, et al. Childhood functional gastrointestinal disorders. Gut 1999;45Suppl 2:II60–II68.

    PubMed  Google Scholar 

  7. Uc A, Hyman PE, Walker LS. Functional gastrointestinal disorders in African American children in primary care. J Pediatr Gastroenterol Nutr 2006;42:270–274.

    Article  PubMed  Google Scholar 

  8. Walker L, Lipani T, Greene J, Caines K, Stutts J, Polk D, et al. Recurrent abdominal pain: symptom subtypes based on the Rome II criteria for pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr 2004;38:187–191.

    Article  PubMed  Google Scholar 

  9. Schurman JV, Friesen CA, Danda CE, Andre L, Welchert E, Lavenbarg T, et al. Diagnosing functional abdominal pain with the Rome II criteria: parent, child, and clinician agreement. J Pediatr Gastroenterol Nutr 2005;41:291–295.

    Article  PubMed  Google Scholar 

  10. Caplan A, Walker L, Rasquin A. Validation of the pediatric Rome II criteria for functional gastrointestinal disorders using the questionnaire on pediatric gastrointestinal symptoms. J Pediatr Gastroenterol Nutr 2005;41:305–316.

    Article  PubMed  Google Scholar 

  11. Di Lorenzo C, Colletti RB, Lehmann HP, Boyle JT, Gerson WT, Hyams JS, et al. Chronic abdominal pain in children: a clinical report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:245–248.

    Article  PubMed  Google Scholar 

  12. Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, et al. Childhood functional gastrointestinal disorders: child/adolescent. Gastroenterology 2006;130:1527–1537.

    Article  PubMed  Google Scholar 

  13. Baber KF, Anderson J, Puzanovova M, Walker LS. Rome II versus Rome III classification of functional gastrointestinal disorders in pediatric chronic abdominal pain. J Pediatr Gastroenterol Nutr 2008;47:299–302.

    Article  PubMed  Google Scholar 

  14. Arnhold RG, Callas ER. Composition of a suburban pediatric office practice: an analysis of patient visits during one year. Clin Pediatr 1996;5:722–727.

    Article  Google Scholar 

  15. Hyams JS, Burke G, Davis PM, Rzepski B, Andrulonis PA. Abdominal pain and irritable bowel syndrome in adolescents: a community-based study. J Pediatr 1996;129:220–226.

    Article  PubMed  CAS  Google Scholar 

  16. Chitkara DK, Rawat DJ, Talley NJ. The epidemiology of childhood recurrent abdominal pain in Western countries: a systematic review. Am J Gastroenterol 2005;100:1868–1875.

    Article  PubMed  Google Scholar 

  17. Petersen S, Bergstrom E, Brulin C. High prevalence of tiredness and pain in young school children. Scand J Public Health 2003;31:367–374.

    Article  PubMed  Google Scholar 

  18. Saps M, Li B. Chronic abdominal pain of functional origin in children. Pediatr Ann 2006;35:246–256.

    PubMed  Google Scholar 

  19. Perquin CW, Hazebroek-Kampschreur AA, Hunfeld JA, Bohnen AM, van Suijlekom-Smit LW, Passchier J, et al. Pain in children and adolescents: a common experience. Pain 2000;87:51–58.

    Article  PubMed  CAS  Google Scholar 

  20. Bode G, Brenner H, Adler G, Rothenbacher D. Recurrent abdominal pain in children: evidence from a population-based study that social and familial factors play a major role but not Helicobacter pylori infection. J Psychosom Res 2003;54:417–421.

    Article  PubMed  Google Scholar 

  21. Hotopf M, Carr S, Mayou R, Wadsworth M, Wessely S. Why do children have chronic abdominal pain and what happens to them when they grow up? Population based cohort study. BMJ 1998;316:1196–1200.

    PubMed  CAS  Google Scholar 

  22. Boey C, Goh K. The significance of life events as contributing factors in childhood recurrent abdominal pain in an urban community in Malaysia. J Psychosom Res 2001;51:559–562.

    Article  PubMed  CAS  Google Scholar 

  23. Logan D, Scharff L. Relationships between family and parent characteristics and functional abilities in children with recurrent pain syndromes: an investigation of moderating effects on the pathway from pain to disability. J Pediatr Psychol 2005;30:698–707.

    Article  PubMed  Google Scholar 

  24. Malaty HM, Abudayyeh S, O’Malley KJ, Wilsey MJ, Fraley K, Gilger MA, et al. Development of a multidimensional measure for recurrent abdominal pain in children: population based studies in three settings. Pediatrics 2005;115:e210–e215.

    Article  PubMed  Google Scholar 

  25. Hunfeld JA, Perquin CW, Duivenvoorden HJ, Hazebroek-Kampschreur AA, Passchier J, Van Suijlekom-Smit LW, et al. Chronic pain and its impact on quality of life in adolescents and their families. J Pediatr Psychol 2001;26:145–153.

    Article  PubMed  CAS  Google Scholar 

  26. Lipani TA, Walker LS. Children’s appraisal and coping with pain: relation to maternal ratings of worry and restriction in family activities. J Pediatr Psychol 2006;31:667–673.

    Article  PubMed  Google Scholar 

  27. Liebman WM. Recurrent abdominal pain in children: a retrospective survey of 119 patients. Clin Pediatr 1978;17:149–153.

    Article  CAS  Google Scholar 

  28. Garber J, Zeman J, Walker LS. Recurrent abdominal pain in children: psychiatric diagnoses and parental psychopathology. J Am Acad Child Adolesc Psychiatry 1990;29:648–656.

    Article  PubMed  CAS  Google Scholar 

  29. Whorwell PJ, McCallum M, Creed FH. Non-colonic features of irritable bowel syndrome. Gut 1986;27:37–40.

    Article  PubMed  CAS  Google Scholar 

  30. White K, Farrell A. Anxiety and psychosocial stress as predictors of headache and abdominal pain in urban early adolescents. J Pediatr Psychol 2006;31:582–596.

    Article  PubMed  Google Scholar 

  31. Campo J, Bridge J, Ehmann M, Altman S, Lucas A, Birmaher B, et al. Recurrent abdominal pain, anxiety and depression in primary care. J Pediatr 2004;113:817–824.

    Article  Google Scholar 

  32. Youssef NN, Murphy TG, Langseder AL, Rosh JR. Quality of life for children with functional abdominal pain: a comparison study of patients’ and parents’ perceptions. Pediatrics 2006;117:54–59.

    Article  PubMed  Google Scholar 

  33. Guite JW, Lobato DJ, Shalon L, Plante W, Kao BT. Pain, disability, and symptoms among siblings of children with functional abdominal pain. J Dev Behav Pediatr 2007;28:2–8.

    Article  PubMed  Google Scholar 

  34. Greco L, Freeman K, Dufton L. Overt and relational victimization among children with frequent abdominal pain: links to social skills, academic functioning, and health service use. J Pediatr Psychol 2007;32:319–329.

    Article  PubMed  Google Scholar 

  35. Campo J, Comer D, Jansen-McWilliams L, Gardner W, Kelleher K. Recurrent pain, emotional distress, and health service use in childhood. J Pediatr 2002;141:76–83.

    Article  PubMed  Google Scholar 

  36. Crushell E, Rowland M, Doherty M, Gormally S, Harty S, Bourke B, et al. Importance of parental conceptual model of illness in severe recurrent abdominal pain. Pediatrics 2003;112:1368–1372.

    Article  PubMed  Google Scholar 

  37. Lindley KJ, Glaser D, Milla PJ. Consumerism in healthcare can be detrimental to child health: lessons from children with functional abdominal pain. Arch Dis Child 2005;90:335–337.

    Article  PubMed  CAS  Google Scholar 

  38. Thomson AB, Barkun AN, Armstrong D, Chiba N, White RJ, Daniels S, et al. The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment — Prompt Endoscopy (CADET-PE) study. Aliment Pharmacol Ther 2003;17:1481–1491.

    Article  PubMed  CAS  Google Scholar 

  39. Perez ME, Youssef NN. Dyspepsia in childhood and adolescence: insights and treatment considerations. Curr Gastroenterol Rep 2007;9:447–455.

    Article  PubMed  Google Scholar 

  40. Hyams JS, Davis P, Sylvester FA, Zeiter DK, Justinich CJ, Lerer T. Dyspepsia in children and adolescents: a prospective study. J Pediatr Gastroenterol Nutr 2000;30:413–418.

    Article  PubMed  CAS  Google Scholar 

  41. Hoffman I, Vos R, Tack J. Assessment of gastric sensorimotor function in paediatric patients with unexplained dyspeptic symptoms and poor weight gain. Neurogastroenterol Motil 2007;19:173–179.

    Article  PubMed  CAS  Google Scholar 

  42. Chitkara DK, Camilleri M, Zinsmeister AR, Burton D, El-Youssef M, Freese D, et al. Gastric sensory and motor abnormalities in adolescents with functional dyspepsia. J Pediatr 2005;146:500–505.

    Article  PubMed  Google Scholar 

  43. Riezzo G, Chiloiro M, Guerra V, Borrelli O, Salvia G, Cucchiara S. Comparison of gastric electrical activity and gastric emptying in healthy and dyspeptic children. Dig Dis Sci 2000;45:517–524.

    Article  PubMed  CAS  Google Scholar 

  44. Chitkara DK, Delgado-Aros S, Bredenoord AJ, Cremonini F, El-Youssef M, Freese D, et al. Functional dyspepsia, upper gastrointestinal symptoms and transit in children. J Pediatr 2003;143:609–613.

    Article  PubMed  Google Scholar 

  45. Talley NJ, Locke GR 3rd, Lahr BD, Zinsmeister AR, Tougas G, Ligozio G, et al. Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut 2006;55:933–939.

    Article  PubMed  CAS  Google Scholar 

  46. Kleibeuker JH, Thijs JC. Functional dyspepsia. Curr Opin Gastroenterol 2004;20:546–550.

    Article  PubMed  Google Scholar 

  47. Shulman RJ, Eakin MN, Jarrett M, Czyzewski DI, Zeltzer LK. Characteristics of pain and stooling in children with recurrent abdominal pain. J Pediatr Gastroenterol Nutr 2007;44:203–208.

    Article  PubMed  Google Scholar 

  48. Talley NJ, Vakil N; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for the management of dyspepsia. Am J Gastroenterol 2005;100:2324–2337.

    Article  PubMed  Google Scholar 

  49. Tally NJ. How to manage the difficult-to-treat dyspeptic patient. Nat Clin Pract Gastroenterol Hepatol 2007;4:35–42.

    Article  Google Scholar 

  50. Moayyedi P, Delaney BC, Vakil N, Forman D, Tally NJ. The efficacy of proton pump inhibitors in nonulcer dyspepsia: a systemic review and economic analysis. Gastroenterology 2004;127:1329–1337.

    Article  PubMed  Google Scholar 

  51. See MC, Birnbaum AH, Schechter CB, Goldenberg MM, Benkov KJ. Double-blinded, placebo controlled trial of famotidine in children with abdominal pain and dyspepsia: global and quantitative assessment. Dig Dis Sci 2001;46:985–992.

    Article  PubMed  CAS  Google Scholar 

  52. Arts J, Caenepeel P, Verbeke K, Tack J. Influence of erythromycin on gastric emptying and meal related symptoms in functional dyspepsia with delayed gastric emptying. Gut 2005;54:455–460.

    Article  PubMed  CAS  Google Scholar 

  53. Holtmann G, talley NJ, Liebregts T, Adam B, Parow C. A placebo-controlled trial of itopride in functional dyspepsia. N Engl J Med 2006;354:832–840.

    Article  PubMed  CAS  Google Scholar 

  54. Talley NJ, Tack J, Ptak T, Gupta R, Giguere M. Itopride in functional dyspepsia: results of two phase III multicenter, randomized, double-blind, placebo-controlled trials. Gut 2008;57:740–746.

    Article  PubMed  CAS  Google Scholar 

  55. Calvert EL, Houghton LA, Cooper P, Morris J, Whorwell PJ. Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology 2002;123:1778–1785.

    Article  PubMed  Google Scholar 

  56. Xu S, Hou X, Zha H, Gao Z, Zhang Y, Chen JD. Electroacupuncture accelerates solid gastric emptying and improves dyspeptic symptoms in patients with functional dyspepsia. Dig Dis Sci 2006;51:2154–2159.

    Article  PubMed  Google Scholar 

  57. Hasler WL. The irritable bowel syndrome during pregnancy. Gastroenterol Clin North Am 2003;32:385–406.

    Article  PubMed  Google Scholar 

  58. Cash BD, Chey WD. Advances in the management of irritable bowel syndrome. Curr Gastroeneterol Rep 2003;5:468–475.

    Article  Google Scholar 

  59. Torii A, Toda G. Management of irritable bowel syndrome. Intern Med 2004;43:353–359.

    Article  PubMed  CAS  Google Scholar 

  60. Lee OY, Mayer EA, Schmulson M, Naliboff B. Genderrelated differences in IBS symptoms. Am J Gastroenterol 2001;96:2184–2193.

    Article  PubMed  CAS  Google Scholar 

  61. Anderson JL, Acra S, Bruehl S, Walker LS. Relation between clinical symptoms and experimental visceral hypersensitivity in pediatric patients with functional abdominal pain. J Pediatr Gastroenterol Nutr 2008;47:309–315.

    Article  PubMed  Google Scholar 

  62. Lawal A, Kern M, Sidhu H, Hofmann C, Shakr R. Novel evidence for hypersensitivity of visceral sensory neural circuitry in irritable bowel syndrome patients. Gastroenterology 2006;130:26–33.

    Article  PubMed  Google Scholar 

  63. Naliboff BD, Berman S, Suyenobu B, Labus JS, Chang L, Stains J, et al. Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients. Gastroenterology 2006;131:352–365.

    Article  PubMed  Google Scholar 

  64. Van Ginkel R, Voskuijl WP, Benninga MA, Taminiau JA, Boeckxstaens GE. Alterations in rectal sensitivity and motility in childhood irritable bowel syndrome. Gastroenterology 2001;120:31–38.

    Article  PubMed  Google Scholar 

  65. Faure C, Wieckowska A. Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders. J Pediatr 2007;150:66–71.

    Article  PubMed  Google Scholar 

  66. Castilloux J, Noble A, Faure C. Is visceral hypersensitivity correlated with symptom severity in children with functional gastrointestinal disorders? J Pediatr Gastroenterol Nutr 2008;46:272–278.

    Article  PubMed  Google Scholar 

  67. Saps M, Pensabene L, Di Martino L, Staiano A, Wechsler J, Zheng X, et al. Post-infectious functional gastrointestinal disorders in children. J Pediatr 2008;152:812–816.

    Article  PubMed  Google Scholar 

  68. Mearin F, Perez-Oliveras M, Perello A, Vinyet J, Ibañez A, Coderch J, et al. Dyspepsia and irritable bowel syndrome after a Salmonella gastroenteritis outbreak: one-year followup cohort study. Gastroenterology 2005;129:98–104.

    Article  PubMed  Google Scholar 

  69. Shulman RJ, Eakin MN, Czyzewski DI, Jarrett M, Ou C. Increased gastrointestinal permeability and gut inflammation in children with functional abdominal pain and irritable bowel syndrome. J Pediatr 2008;153:646–650.

    Article  PubMed  Google Scholar 

  70. Walker LS, Smith CA, Garber J, Claar RL. Appraisal and coping with daily stressors by pediatric patients with chronic abdominal pain. J Pediatr Psychol 2007;32:206–216.

    Article  PubMed  Google Scholar 

  71. Kaminsky L, Robertson M, Dewey D. Psychological correlates of depression in children with recurrent abdominal pain. J Pediatr Psychol 2006;31:956–966.

    Article  PubMed  Google Scholar 

  72. Locke GR 3rd, Zinsmeister AR, Talley NJ, Fett SL, Melton LJ 3rd. Familial association in adults with functional gastrointestinal disorders. Mayo Clin Proc 2000;75:907–912.

    Article  PubMed  Google Scholar 

  73. Campo JV, Bridge J, Lucas A, Savorelli S, Walker L, Di Lorenzo C, et al. Physical and emotional health of mothers of youth with functional abdominal pain. Arch Pediatr Adolesc Med 2007;161:131–137.

    Article  PubMed  Google Scholar 

  74. Tally NJ. Genes and environment in irritable bowel syndrome: one step forward. Gut 2006;55:1694–1696.

    Article  Google Scholar 

  75. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Entericcoated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125–128.

    Article  PubMed  CAS  Google Scholar 

  76. Gawronska A, Dziechciarz P, Horvath A, Szajewska H. A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain in children. Aliment Pharmacol Ther 2007;25:177–184.

    PubMed  CAS  Google Scholar 

  77. O’Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, et al. Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005;128:541–551.

    Article  PubMed  Google Scholar 

  78. Whorwell PJ, Altringer L, Morel J, Bond Y, Charbonneau D, O’Mahony L, et al. Efficacy of an encapsulated probiotic Bifidobacterium infantalis 35624 in women with irritable bowel syndrome. Am J Gastroenterol 2006;101:1581–1590.

    Article  PubMed  Google Scholar 

  79. Pimentel M, park S, Mirocha J, Kane SV, Kong Y. The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial. Ann Intern Med 2006;145:557–563.

    PubMed  Google Scholar 

  80. Campo JV, Perel J, Lucas A, Bridge J, Ehmann M, Kalas C, et al. Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study. J Am Acad Child Adolesc Psychiatry 2004;43:1234–1242.

    Article  PubMed  Google Scholar 

  81. Bahar RJ, Collins BS, Steinmetz B, Ament ME. Doubleblind placebo-controlled trial of amitriptyline for the treatment of irritable bowel syndrome in adolescents. J Pediatr 2008;152:685–689.

    Article  PubMed  CAS  Google Scholar 

  82. Johanson JF, Drossman DA, Panas R, Wahle A, Ueno R. Clinical trial: phase 2 study of lubiprostone for irritable bowel syndrome with constipation. Aliment Pharmacol Ther 2008;27:685–696.

    PubMed  CAS  Google Scholar 

  83. Feldman W, McGrath P, Hodgson C, Ritter H, Shipman RT. The use of dietary fiber in the management of simple, childhood, idiopathic, recurrent, abdominal pain: results in a prospective, double-blind, randomized, controlled trial. Am J Dis Child 1985;139:1216–1218.

    PubMed  CAS  Google Scholar 

  84. Huertas-Ceballos A, Logan S, Bennett C, Macarthur C. Dietary interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst Rev 2008;CD003019.

  85. Vlieger AM, Menko-Frankenhuis C, Wolfkamp SC, Tromp E, Benninga MA. Hypnotherapy for children with functional abdominal pain or irritable bowel syndrome: a randomized controlled trial. Gastroenterology 2007;133:1430–1436.

    Article  PubMed  Google Scholar 

  86. Huertas-Ceballos A, Logan S, Bennett C, Macarthur C. Psychosocial interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Syst Rev 2008;CD003014.

  87. Boyle JT. Recurrent abdominal pain: an update. Pediatr Rev 1997;18:310–321.

    Article  PubMed  CAS  Google Scholar 

  88. Walker LS, Williams SE, Smith CA, Garber J, Van Slyke DA, Lipani TA. Parent attention versus distraction: impact on symptom complaints by children with and without chronic functional abdominal pain. Pain 2006;122:43–52.

    Article  PubMed  Google Scholar 

  89. Robins PM, Smith SM, Glutting JJ, Bishop CT. A randomized controlled trial of a cognitive-behavioral family intervention for pediatric recurrent abdominal pain. J Pediatr Psychol 2005;30:397–408.

    Article  PubMed  Google Scholar 

  90. Youssef NN, Rosh JR, Loughran M, Schuckalo SG, Cotter AN, Verga BG, et al. Treatment of functional abdominal pain in childhood with cognitive behavioral strategies. J Pediatr Gastroenterol Nutr 2004;39:192–196.

    Article  PubMed  Google Scholar 

  91. Vlieger AM, Blink M, Tromp E, Benninga MA. Use of complementary and alternative medicine by pediatric patients with functional and organic gastrointestinal diseases: results from a multicenter survey. Pediatrics 2008;122:e446–451.

    Article  PubMed  Google Scholar 

  92. Li BU, Balint JP. Cyclic vomiting syndrome: evolution in our understanding of a brain-gut disorder. Adv Pediatr 2000;47:117–160.

    PubMed  CAS  Google Scholar 

  93. Mortimer MJ, Good PA. The VER as a diagnostic marker for childhood abdominal migraine. Headache 1990;30:642–645.

    Article  PubMed  CAS  Google Scholar 

  94. Good PA. Neurologic investigations of childhood abdominal migraine: a combined electrophysiologic approach to diagnosis. J Pediatr Gastroenterol Nutr 1995;21:S44–48.

    Article  PubMed  Google Scholar 

  95. Tache Y. cyclic vomiting syndrome: the corticotropin-releasing-factor hypothesis. Dig Dis Sci 1999;44:79S–86S.

    Article  PubMed  CAS  Google Scholar 

  96. Wang Q, Ito M, Adams K, Li BU, Klopstock T, Maslim A, et al. Mitochondrial DNA control region sequence variation in migraine headache and cyclic vomiting syndrome. Am J Med Genet A 2004;131:50–58.

    Article  PubMed  Google Scholar 

  97. Stickler GB. Relationship between cyclic vomiting syndrome and migraine. Clin Pediatr 2005;44:505–508.

    Article  Google Scholar 

  98. Li BU, Lefevre F, Chelimsky GG, Boles RG, Nelson SP, Lewis DW, et al. North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition concensus statement on the diagnosis and management of cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 2008;47:379–393.

    Article  PubMed  CAS  Google Scholar 

  99. Olson AD, Li BU. The diagnostic evaluation of children with cyclic vomiting: a cost-effectiveness assessment. J Pediatr 2002;141:724–728.

    Article  PubMed  Google Scholar 

  100. Andersen JM, Sugerman KS, Lockhart JR, Weinberg WA. Effective prophylactic therapy for cyclic vomiting syndrome in children using amitriptyline or cyproheptadine. Pediatrics 1997;100:977–981.

    Article  PubMed  CAS  Google Scholar 

  101. Forbes D, Withers G. Prophylactic therapy in cyclic vomiting syndrome. J Pediatr Gastroenterol Nutr 1995;21:S57–S59.

    PubMed  Google Scholar 

  102. Huang S, Lavine JE. Efficacy of sumatriptan in aborting attacks of cyclic vomiting syndrome. Gastroenterology 1997;112:751A.

    Google Scholar 

  103. Li BU, Murray RD, Heitlinger LA, Robbins JL, hayes JR. Is cyclic vomiting syndrome related to migraine? J Pediatr 1999;134:567–572.

    Article  PubMed  CAS  Google Scholar 

  104. Halder SL, Locke GR 3rd, Schleck CD, Zinsmeister AR, Melton LJ 3rd, Talley NJ. Natural history of functional gastrointestinal disorders: a 12-year longitudinal population-based study. Gastroenterology 2007;133:799–807.

    Article  PubMed  Google Scholar 

  105. Boyle JT. Abdominal Pain. In: Walker WA, Goulet O, Kleinman RE, Sherman PM, Schneider BL, Sanderson IR, eds. Pediatric Gastrointestinal Disease: Pathophysiology-Diagnosis-Management, 4th ed. Hamilton, ON: BC Decker Inc, 2004: 225–243.

    Google Scholar 

  106. Perquin CW, Hunfeld JA, Hazebroek-Kampschreur AA, Van Suijlekom-Smit LW, Passchier J, Koes BW, et al. The natural course of chronic benign pain in childhood and adolescence: a two year population-based follow up study. Eur J Pain 2003;7:551–559.

    Article  PubMed  Google Scholar 

  107. Jarrett M, Heitkemper M, Czyzewski DI, Shulman R. Recurrent abdominal pain in children: forerunner to adult irritable bowel syndrome? J Spec Pediatr Nurs 2003;8:81–89.

    Article  PubMed  Google Scholar 

  108. Campo JV, Di Lorenzo C, Chiappetta L, Bridge J, Colborn DK, Gartner JC Jr, et al. Adult outcomes of pediatric recurrent abdominal pain: do they just grow out of it? Pediatrics 2001;108:E1.

    Article  PubMed  CAS  Google Scholar 

  109. Sloth H, Jorgensen LS. Predictors for the course of chronic non-organic upper abdominal pain. Scan J Gastroenterol 1989;24:440–444.

    Article  CAS  Google Scholar 

  110. Mearin F, Badia X, Balboa A, Benavent J, Caballero AM, Dominguez-Munoz E, et al. Predictive factors of irritable bowel syndrome improvement: 1-year prospective evaluation in 400 patients. Aliment Pharmacol Ther 2006;23:815–826.

    Article  PubMed  CAS  Google Scholar 

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  1. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Indiana University School of Medicine, Indianapolis, IN, USA

    Rana Fayez Ammoury, Marian Del Rosario Pfefferkorn & Joseph Marino Croffie

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  1. Rana Fayez Ammoury
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Ammoury, R.F., Pfefferkorn, M.D.R. & Croffie, J.M. Functional gastrointestinal disorders: past and present. World J Pediatr 5, 103–112 (2009). https://doi.org/10.1007/s12519-009-0021-6

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