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State of the Art in Cardiovascular T2 Mapping: on the Way to a Cardiac Biomarker?

  • Cardiac Magnetic Resonance (E Nagel and V Puntmann, Section Editors)
  • Published:
Current Cardiovascular Imaging Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Parametric mapping fosters the role of cardiovascular magnetic resonance in its unique capability to evaluate myocardial tissue without the use of contrast agents. While there is a large body of literature highlighting the role of T1 mapping, the role of T2 mapping is less clear. This review aims to address the latest evidences for added clinical value of T2 mapping.

Recent Findings

T2 mapping shows superior diagnostic accuracy in myocarditis, transplant rejection, and cardiac involvement in lupus erythematosus. Moreover, T2 values predict major adverse cardiovascular events in myocarditis and enable therapy monitoring in lupus erythematosus as well as after heart transplantation. In ischemic cardiomyopathy, T2 mapping discriminates acute from chronic injury and provides additional information for patient risk stratification.

Summary

T2 mapping provides a robust, quantifiable non-contrast-enhanced myocardial biomarker. However, there is no standardization in acquisition protocols, which formulates the future need for standardization ahead of multi-center trails.

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Abbreviations

AAR:

Area-at-risk

AMI:

Acute myocardial infarction

CMR:

Cardiac magnetic resonance

DB-TSE:

Dark-blood turbo spin echo

DCM:

Dilated cardiomyopathy

EMB:

Endomyocardial biopsy

ICM:

Ischemic cardiomyopathy

LGE:

Late gadolinium enhancement

LLC:

Lake-Louise Criteria

MACE:

Major adverse cardiovascular events

SI:

Signal intensity

SSFP:

Steady-state free precession

T2-prep:

Bright-blood pulse sequences with a spin-echo-like preparation

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Authors and Affiliations

  1. Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Düsseldorf, Germany

    Sebastian M. Haberkorn, Maximilian Spieker, Christoph Jacoby, Malte Kelm & Florian Bönner

  2. CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty, Heinrich-Heine-University, Moorensstrasse 5, 40225, Düsseldorf, Germany

    Ulrich Flögel & Malte Kelm

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  1. Sebastian M. Haberkorn
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  2. Maximilian Spieker
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Correspondence to Florian Bönner.

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Haberkorn, S.M., Spieker, M., Jacoby, C. et al. State of the Art in Cardiovascular T2 Mapping: on the Way to a Cardiac Biomarker?. Curr Cardiovasc Imaging Rep 11, 15 (2018). https://doi.org/10.1007/s12410-018-9455-3

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