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ADHD symptomatology is best conceptualized as a spectrum: a dimensional versus unitary approach to diagnosis

  • Review Article
  • Published:
ADHD Attention Deficit and Hyperactivity Disorders

Abstract

The aim of this paper is to build a case for the utility of conceptualizing ADHD, not as a unitary disorder that contains several subtypes, but rather as a marker of impairment in attention and/or impulsivity that can be used to identify one of several disorders belonging to a spectrum. The literature will be reviewed to provide an overview of what is known about ADHD in terms of heterogeneity in symptomatology, neuropsychology, neurobiology, as well as comorbidity with other diseases and treatment options. The data from these areas of research will be critically analyzed to support the construct of a spectrum of disorders that can capture the great variability that exists between individuals with ADHD and can discriminate between separate disorders that manifest similar symptoms. The symptoms associated with ADHD can be viewed as dimensional markers that point to a spectrum of related disorders that have as part of their characteristics impairments of attention and impulsivity. The spectrum can accommodate symmetrically and asymmetrically comorbid psychiatric disorders associated with ADHD as well as the wide heterogeneity known to be a part of the ADHD disorder. Individuals presenting with impairments associated with ADHD should be treated as having a positive marker for a spectrum disorder that has as part of its characteristics impairments of attention and/or impulsivity. The identification of impairment in attention and/or impulsivity should be a starting point for further testing rather than being an endpoint of diagnosis that results in pharmacological treatment that may or may not be the optimal therapy. Rather than continuing to attribute a large amount of heterogeneity in symptom presentation as well as a high degree of symmetric and asymmetric comorbidity to a single disorder, clinical evaluation should turn to the diagnosis of the type of attentional deficit and/or impulsivity an individual has in order to colocate the individual’s disorder on a spectrum that captures the heterogeneity in symptomatology, the symmetrical and asymmetrical comorbidity, as well as subthreshold presentation and other variants often worked into the disorder of ADHD. The spectrum model can accommodate not only the psychophysiological profiles of patients, but is also consistent with what is known about the functional heterogeneity of the prefrontal cortex as well as the construct that cognitive processes are supported by overlapping and collaborative networks.

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References

  • Almeida LG, Ricardo-Garcell J, Prado H, Barajas L, Fernández-Bouzas A, Ávila D, Martínez RB (2010) Reduced right frontal cortical thickness in children, adolescents and adults with ADHD and its correlation to clinical variables: a cross-sectional study. J Psychiatr Res 44(16):1214–1223

    PubMed  Google Scholar 

  • Alvarez JA, Emory E (2006) Executive function and the frontal lobes: a meta-analytic review. Neuropsychol Rev 16(1):17–42

    PubMed  Google Scholar 

  • American Psychiatric Association (1968) Diagnostic and statistical manual of mental disorders, 2nd edn. Author, Washington, DC

    Google Scholar 

  • American Psychiatric Association (1980) Diagnostic and statistical manual of mental disorders, 3rd edn. Author, Washington, DC

    Google Scholar 

  • American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn. Author, Washington, DC

    Google Scholar 

  • American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. Author, Washington, DC

    Google Scholar 

  • American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders DSM-IV-TR, 4th edn. Author, Washington, DC

    Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, (DSM-5®). American Psychiatric Pub, Washington, DC

    Google Scholar 

  • Anastopoulos A, Barkley R, Shelton T (1994) The history and diagnosis of attention deficit/hyperactivity disorder. Ther Care Educ 3:96

    Google Scholar 

  • Antshel KM, Barkley R (2011) Overview and historical background of attention deficit hyperactivity disorder. In: Evans SW, Hoza B (eds) Treating attention-deficit = hyperactivity disorder: assessment and intervention in developmental context. Civic Research Institute, New York, NY, pp 1–30

    Google Scholar 

  • Arnett AB, MacDonald B, Pennington BF (2013) Cognitive and behavioral indicators of ADHD symptoms prior to school age. J Child Psychol Psychiatry 54(12):1284–1294

    PubMed  Google Scholar 

  • Arnett AB, Pennington BF, Willcutt EG, DeFries JC, Olson RK (2014) Sex differences in ADHD symptom severity. J Child Psychol Psychiatry. doi:10.1111/jcpp.12337

    PubMed  Google Scholar 

  • Asperger H (1979) Problems of infantile autism. Communication 13:45–52

    Google Scholar 

  • Baeyens D, Roeyers H, Walle JV (2006) Subtypes of attention-deficit/hyperactivity disorder (ADHD): distinct or related disorders across measurement levels? Child Psychiatry Hum Dev 36(4):403–417

    PubMed  Google Scholar 

  • Bagot KS, Kaminer Y (2014) Efficacy of stimulants for cognitive enhancement in non-attention deficit hyperactivity disorder youth: a systematic review. Addiction 109(4):547–557

    PubMed Central  PubMed  Google Scholar 

  • Balázs J, Keresztény Á (2014) Subthreshold attention deficit hyperactivity in children and adolescents: a systematic review. Eur Child Adolesc Psychiatry 23:1–16

    Google Scholar 

  • Banaschewski T, Hollis C, Oosterlaan J, Roeyers H, Rubia KWE (2005) Towards an understanding of unique and shared pathways in the psychopathophysiology of AD/HD. Dev Sci 8:132–140

    PubMed  Google Scholar 

  • Banich MT, Burgess GC, Depue BE, Ruzic L, Bidwell L, Hitt-Laustsen S, Du YP, Willcutt EG (2009) The neural basis of sustained and transient attentional control in young adults with ADHD. Neuropsychologia 47(14):3095–3104

    PubMed Central  PubMed  Google Scholar 

  • Barkley RA (1997) Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121(1):65

    CAS  PubMed  Google Scholar 

  • Barkley RA (2001) The inattentive type of ADHD as a distinct disorder: what remains to be done. Clin Psychol Sci Pract 8(4):489–493

    Google Scholar 

  • Barkley RA (2005) Attention-deficit hyperactivity disorder: a handbook for diagnosis and treatment (Vol 1). Guilford Press, Newyork

    Google Scholar 

  • Barkley RA (2007) What may be in store for DSM-V. ADHD Rep 15:1–7

    Google Scholar 

  • Barkley RA (2012) Executive functions: what they are, how they work, and why they evolved. Guilford Press, Newyork

    Google Scholar 

  • Barkley RA (2013) Distinguishing sluggish cognitive tempo from ADHD in children and adolescents: executive functioning, impairment, and comorbidity. J Clin Child Adolesc Psychol 42(2):161–173

    PubMed  Google Scholar 

  • Barkley R, Peters H (2012) The earliest reference to ADHD in the medical literature? Melchior Adam Weikard’s description in 1775 of “attention deficit” (Mangel der Aufmerksamkeit, Attentio Volubilis). J Atten Disord 16(8):623–630

    PubMed  Google Scholar 

  • Bauermeister JJ, Barkley RA, Bauermeister JA, Martinez JV, McBurnett K (2012) Validity of the sluggish cognitive tempo, inattention, and hyperactivity symptom dimensions: neuropsychological and psychosocial correlates. J Abnormal Child Psychol 40:683–697

    Google Scholar 

  • Becker SP, Marshall SA, McBurnett K (2014) Sluggish cognitive tempo in abnormal child psychology: an historical overview and introduction to the Special Section. J Abnormal Child Psychol 42(1):1–6

    Google Scholar 

  • Bédard ACV, Newcorn JH, Clerkin SM, Krone B, Fan J, Halperin JM, Schulz KP (2014) Reduced Prefrontal efficiency for visuospatial working memory in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 53(9):1020–1030

    PubMed  Google Scholar 

  • Bédard ACV, Stein MA, Halperin JM, Krone B, Rajwan E, Newcorn JH (2015) Differential impact of methylphenidate and atomoxetine on sustained attention in youth with attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry 56(1):40–48

    PubMed  Google Scholar 

  • Bell AS (2011) A critical review of ADHD diagnostic criteria: what to address in the DSM-V. J Atten Disord 15(1):3–10

    PubMed  Google Scholar 

  • Bell EC, Willson MC, Wilman AH, Dave S, Silverstone PH (2006) Males and females differ in brain activation during cognitive tasks. Neuroimage 30(2):529–538

    PubMed  Google Scholar 

  • Berry CA, Shaywitz SE, Shaywitz BA (1985) Girls with attention deficit disorder: a silent minority? A report on behavioral and cognitive characteristics. Pediatrics 76(5):801–809

    CAS  PubMed  Google Scholar 

  • Biederman J, Newcorn J, Sprich S (1991) Comorbidity of attention deficit hyperactivity disorder. Am J Psychiatry 148(5):564–577

    CAS  PubMed  Google Scholar 

  • Bolea-Alamañac B, Nutt DJ, Adamou M, Asherson P, Bazire S, Coghill D, Heal D, Müller U, Nash J, Santosh P, Sayag K, Sonuga-Barke E, Young SJ (2014) Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: update on recommendations from the British Association for Psychopharmacology. J Psychopharmacol 28(3):179–203

    PubMed  Google Scholar 

  • Bonafina MA, Newcorn JH, McKay KE, Koda VH, Halperin JM (2000) ADHD and reading disabilities a cluster analytic approach for distinguishing subgroups. J Learn Disabil 33(3):297–307

    CAS  PubMed  Google Scholar 

  • Booth JR, Burman DD, Meyer JR, Lei Z, Trommer BL, Davenport ND, Li W, Parrish TB, Gitleman DR, Marsel Mesulam M (2005) Larger deficits in brain networks for response inhibition than for visual selective attention in attention deficit hyperactivity disorder (ADHD). J Child Psychol Psychiatry 46(1):94–111

    PubMed  Google Scholar 

  • Brown TE (2006) Executive functions and attention deficit hyperactivity disorder: implications of two conflicting views. Int J Disabil Dev Educ 53(1):35–46

    Google Scholar 

  • Bruchmüller K, Margraf J, Schneider S (2012) Is ADHD diagnosed in accord with diagnostic criteria? Overdiagnosis and influence of client gender on diagnosis. J Consult Clin Psychol 80(1):128

    PubMed  Google Scholar 

  • Burgess GC, Depue BE, Ruzic L, Willcutt EG, Du YP, Banich MT (2010) Attentional control activation relates to working memory in attention-deficit/hyperactivity disorder. Biol Psychiatry 67(7):632–640. Child Psychol 29(6):529–540

    PubMed Central  PubMed  Google Scholar 

  • Cao M, Shu N, Cao Q, Wang Y, He Y (2014) Imaging functional and structural brain connectomics in attention-deficit/hyperactivity disorder. Mol Neurobiol 50:1–13

    Google Scholar 

  • Carlson CL (1986) Attention deficit disorder with and without hyperactivity: a review of preliminary experimental evidence. In: Lahey BB, Kazdin AE (eds) Advances in clinical child psychology, vol 9. Plenum, New York, NY, pp 153–175

    Google Scholar 

  • Carlson CL, Mann M (2000) Attention-deficit/hyperactivity disorder, predominately inattentive subtype. Child Adolesc Psychiatr Clin N Am 9(3):499–510, vi. Review

  • Carlson CL, Mann M (2002) Sluggish cognitive tempo predicts a different pattern of impairment in the attention deficit hyperactivity disorder, predominantly inattentive type. J Clin Child Adolesc Psychol 31(1):123–129

    PubMed  Google Scholar 

  • Carpenter PA, Just MA, Reichle ED (2000) Working memory and executive function: evidence from neuroimaging. Curr Opin Neurobiol 10(2):195–199

    CAS  PubMed  Google Scholar 

  • Castellanos FX, Proal E (2012) Large-scale brain systems in ADHD: beyond the prefrontal–striatal model. Trends Cogn Sci 16(1):17–26

    PubMed Central  PubMed  Google Scholar 

  • Castellanos FX, Tannock R (2002) Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 3(8):617–628

    CAS  PubMed  Google Scholar 

  • Castellanos FX, Lee PP, Sharp W, Jeffries NO, Greenstein DK, Clasen LS, Blumenthal JD, James RS, Ebens CL, Walter JM, Zijdenbos A, Evans AC, Giedd JN, Rapoport JL (2002) Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA 288(14):1740–1748

    PubMed  Google Scholar 

  • Chhabildas N, Pennington BF, Willcutt EG (2001) A comparison of the neuropsychological profiles of the DSM-IV subtypes of ADHD. J Abnorm Child Psychol 29(6):529–540

    CAS  PubMed  Google Scholar 

  • Chudasama Y (2011) Animal models of prefrontal-executive function. Behav Neurosci 125(3):327

    PubMed  Google Scholar 

  • Clark KL, Noudoost B (2014) The role of prefrontal catecholamines in attention and working memory. Front Neural Circuits 8:33. doi:10.3389/fncir.2014.00033 [Erratum in: Front Neural Circuits 2014;8:142]

    PubMed Central  PubMed  Google Scholar 

  • Clemow DB, Walker DJ (2014) The potential for misuse and abuse of medications in ADHD: a review. Postgrad Med 126(5):64–81

    PubMed  Google Scholar 

  • Coghill DR, Seth S, Pedroso S, Usala T, Currie J, Gagliano A (2014) Effects of methylphenidate on cognitive functions in children and adolescents with attention-deficit/hyperactivity disorder: evidence from a systematic review and a meta-analysis. Biol Psychiatry 76(8):603–615

    CAS  PubMed  Google Scholar 

  • Congdon E, Altshuler LL, Mumford JA, Karlsgodt KH, Sabb FW, Ventura J, McGough JJ, London ED, Cannon TD, Bilder RM, Poldrack RA (2014) Neural activation during response inhibition in adult attention-deficit/hyperactivity disorder: preliminary findings on the effects of medication and symptom severity. Psychiatry Res Neuroimaging 222(1):17–28

    PubMed  Google Scholar 

  • Cubillo A, Halari R, Giampietro V, Taylor E, Rubia K (2011) Fronto-striatal underactivation during interference inhibition and attention allocation in grown up children with attention deficit/hyperactivity disorder and persistent symptoms. Psychiatry Res Neuroimaging 193(1):17–27

    PubMed  Google Scholar 

  • Cunill R, Castells X, Tobias A, Capellà D (2015) Pharmacological treatment of attention deficit hyperactivity disorder with co-morbid drug dependence. J Psychopharmacol 29(1):15–23

    CAS  PubMed  Google Scholar 

  • Dagher A, Robbins TW (2009) Personality, addiction, dopamine: insights from Parkinson’s disease. Neuron 61(4):502–510

    CAS  PubMed  Google Scholar 

  • De Quiros GB, Kinsbourne M (2001) Adult ADHD: behavior, self-rating and medication assessment. Ann N Y Acad Sci 931:287–296

    PubMed  Google Scholar 

  • del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW (2011) The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder. Biol Psychiatry 69(12):e145–e157

    PubMed  Google Scholar 

  • Diamond A (2005) Attention-deficit disorder (attention-deficit/hyperactivity disorder without hyperactivity): a neurobiologically and behaviorally distinct disorder from attention-deficit/hyperactivity disorder (with hyperactivity). Dev Psychopathol 17(03):807–825

    PubMed Central  PubMed  Google Scholar 

  • Donohoe G, Robertson IH (2003) Can specific deficits in executive functioning explain the negative symptoms of schizophrenia? A review. Neurocase 9(2):97–108

    CAS  PubMed  Google Scholar 

  • Douglas VI (1972) Stop, look and listen: the problem of sustained attention and impulse control in hyperactive and normal children. Can J Behav Sci 4(4):259

    Google Scholar 

  • Douglas VI (1999) Cognitive control processes in attention deficit/hyperactivity disorder. In: Quay HC, Hogan AE (eds) Handbook of disruptive behavior disorders. Springer, Berlin, pp 105–138

    Google Scholar 

  • Douglas VI (2005) Cognitive deficits in children with attention deficit hyperactivity disorder: a long-term follow-up. Can Psychol 46(1):23

    Google Scholar 

  • Duff CT, Sulla EM (2014) Measuring executive function in the differential diagnosis of attention-deficit/hyperactivity disorder: does it really tell Us anything? Appl Neuropsychol Child 1–9. doi:10.1080/21622965.2013.848329

  • Epstein JN, Erkanli A, Conners CK, Klaric J, Costello JE, Angold A (2003) Relations between continuous performance test performance measures and ADHD behaviors. J Abnorm Child Psychol 31(5):543–554

    PubMed  Google Scholar 

  • Evans S, Owens J, Bunford N (2014) Evidence-based psychosocial treatments for children and adolescents with attention-deficit/hyperactivity disorder. J Clin Child Adolesc Psychol 43(4):1–25

    Google Scholar 

  • Fair D, Bathula D, Nikolas M, Nigg J (2012) Distinct neuropsychological subgroups in typically developing youth inform heterogeneity in children with ADHD. Proc Natl Acad Sci 109(17):6769–6774

    PubMed Central  CAS  PubMed  Google Scholar 

  • Fair DA, Nigg JT, Iyer S, Bathula D, Mills KL, Dosenbach NU, Schlaggar BL, Mennes M, Gutman D, Bangaru S, Buitelaar JK, Dickstein DP, Di Martino A, Kennedy DN, Kelly C, Luna B, Schweitzer JB, Velanova K, Wang YF, Mostofsky F, Castellanos FX, Milham MP (2013) Distinct neural signatures detected for ADHD subtypes after controlling for micro-movements in resting state functional connectivity MRI data. Front Syst Neurosci 6:80. doi:10.3389/fnsys.2012.00080

    PubMed Central  PubMed  Google Scholar 

  • Faraone S (2005) The scientific foundation for understanding attention-deficit/hyperactivity disorder as a valid psychiatric disorder. Eur Child Adolesc Psychiatry 14:1–10

    PubMed  Google Scholar 

  • Faraone SV, Buitelaar J (2010) Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis. Eur Child Adolesc Psychiatry 19(4):353–364

    PubMed  Google Scholar 

  • Faraone SV, Biederman J, Weber W, Russell RL (1998) Psychiatric, neuropsychological, and psychosocial features of DSM-IV subtypes of attention-deficit/hyperactivity disorder: results from a clinically referred sample. J Am Acad Child Adolesc Psychiatry 37(2):185–193

    CAS  PubMed  Google Scholar 

  • Feldman HM, Reiff MI (2014) Attention deficit-hyperactivity disorder in children and adolescents. N Engl J Med 370(9):838–846

    CAS  PubMed  Google Scholar 

  • Ferrer M, Andión Ó, Matalí J, Valero S, Navarro JA, Ramos-Quiroga JA, Torrubia R, Casas M (2010) Comorbid attention-deficit/hyperactivity disorder in borderline patients defines an impulsive subtype of borderline personality disorder. J Pers Disord 24(6):812–822

    PubMed  Google Scholar 

  • Garner AA, Mrug S, Hodgens B, Patterson C (2013) Do symptoms of sluggish cognitive tempo in children with ADHD symptoms represent comorbid internalizing difficulties? J Atten Disord 17(6):510–518. doi:10.1177/1087054711431456

    PubMed  Google Scholar 

  • Gaub M, Carlson CL (1997) Gender differences in ADHD: a meta-analysis and critical review. J Am Acad Child Adolesc Psychiatry 36(8):1036–1045

    CAS  PubMed  Google Scholar 

  • Geller DA (2006) Obsessive-compulsive and spectrum disorders in children and adolescents. Psychiatr Clin North Am 29(2):353–370

    PubMed  Google Scholar 

  • Geurts HM, Verté S, Oosterlaan J, Roeyers H, Sergeant JA (2005) ADHD subtypes: do they differ in their executive functioning profile? Arch Clin Neuropsychol 20(4):457–477

    PubMed  Google Scholar 

  • Goodkind M, Eickhoff SB, Oathes DJ, Jiang Y, Chang A, Jones-Hagata LB, Ortega BN, Zaiko YV, Roach EL, Korgaonkar MS, Grieve SM, Galatzer-Levy I, Fox PT, Etkin A (2015) Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry 72(4):305–315. doi:10.1001/jamapsychiatry.2014.2206

    PubMed  Google Scholar 

  • Graham J, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Dittmann RW, Döpfner M, Hamilton R, Hollis C, Holtmann M, Hulpke-Wette M, Lecendreux M, Rosenthal E, Rothenberger A, Santosh P, Sergeant J, Simonoff E, Sonuga-Barke E, Wong ICK, Zuddas A, Steinhausen HC, Taylor E (2011) European guidelines on managing adverse effects of medication for ADHD. Eur Child Adolesc Psychiatry 20(1):17–37

    PubMed Central  CAS  PubMed  Google Scholar 

  • Greene RW, Biederman J, Faraone SV, Ouellette CA, Penn C, Griffin S (1996) Toward a new psychometric definition of social disability in children with Attention-Deficit Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry 35:571–578

    CAS  PubMed  Google Scholar 

  • Gualtieri CT, Johnson LG (2008) Medications do not necessarily normalize cognition in ADHD patients. J Atten Disord 11(4):459–469

    PubMed  Google Scholar 

  • Hale JB, Reddy LA, Semrud-Clikeman M, Hain LA, Whitaker J, Morley J, Lawrence K, Smith A, Jones N (2011) Executive impairment determines ADHD medication response: implications for academic achievement. J Learn Disabil 44(2):196–212

    PubMed  Google Scholar 

  • Halperin JM, Berwid OG, O’Neill S (2014) Healthy body, healthy mind?: the effectiveness of physical activity to treat ADHD in children. Child Adolesc Psychiatr Clin N Am 23(4):899–936

    PubMed  Google Scholar 

  • Handler MW, DuPaul GJ (2005) Assessment of ADHD: differences across psychology specialty areas. J Atten Disord 9(2):402–412

    PubMed  Google Scholar 

  • Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K (2013) Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention- deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects. JAMA Psychiatry 70(2):185–198

    PubMed  Google Scholar 

  • Haslam N, Williams B, Prior M, Haslam R, Graetz B, Sawyer M (2006) The latent structure of attention-deficit/hyperactivity disorder: a taxometric analysis. Aust N Z J Psychiatry 40(8):639–647

    PubMed  Google Scholar 

  • Heidbreder CA, Groenewegen HJ (2003) The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neurosci Biobehav Rev 27(6):555–579

    PubMed  Google Scholar 

  • Hinshaw SP (2001) Is the inattentive type of ADHD a separate disorder? Clin Psychol Sci Pract 8(4):498–501

    Google Scholar 

  • Hoekzema E, Carmona S, Ramos-Quiroga JA, Richarte Fernández V, Bosch R, Soliva JC, Rovira M, Bulbena A, Tobeña A, Casas M, Vilarroya O (2014) An independent components and functional connectivity analysis of resting state fMRI datapoints to neural network dysregulation in adult ADHD. Hum Brain Mapp 35(4):1261–1272

    PubMed  Google Scholar 

  • Holmes J, Hilton KA, Place M, Alloway TP, Elliott JG, Gathercole SE (2014) Children with low working memory and children with ADHD: same or different? Front Hum Neurosci 8:976. doi:10.3389/fnhum.2014.00976

    PubMed Central  PubMed  Google Scholar 

  • Holtmann M, Sonuga-Barke E, Cortese S, Brandeis D (2014) Neurofeedback for ADHD: a review of current evidence. Child Adolesc Psychiatr Clin N Am 23(4):789–806

    PubMed  Google Scholar 

  • Hong SB, Zalesky A, Fornito A, Park S, Yang YH, Park MH, Song IC, Sohn CH, Shin MS, Kim BN, Cho SC, Han DH, Cheong JH, Kim JW (2014) Connectomic disturbances in attention-deficit/hyperactivity disorder: a whole-brain tractography analysis. Biol Psychiatry 76(8):656–663

    PubMed  Google Scholar 

  • Hoza B, Smith AL, Shoulberg EK, Linnea KS, Dorsch TE, Blazo JA, Alerding CL, McCabe GP (2015) A randomized trial examining the effects of aerobic physical activity on attention-deficit/hyperactivity disorder symptoms in young children. J Abnorm Child Psychol 43(4):655–667. doi:10.1007/s10802-014-9929-y

    PubMed  Google Scholar 

  • Jensen PS, Martin D, Cantwell DP (1997) Comorbidity in ADHD: implications for research, practice, and DSM-V. J Am Acad Child Adolesc Psychiatry 36(8):1065–1079

    CAS  PubMed  Google Scholar 

  • Jensen PS, Hinshaw SP, Kraemer HC, Lenora N, Newcorn JH, Abikoff HB, March JS, Arnold LE, Cantwell DP, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Pelham WE, Severe JB, Swanson JM, Wells KC, Wigal T, Vitiello B (2001a) ADHD comorbidity findings from the MTA study: comparing comorbid subgroups. J Am Acad Child Adolesc Psychiatry 40(2):147–158

    CAS  PubMed  Google Scholar 

  • Jensen PS, Hinshaw SP, Swanson JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn J, Severe JB, Vitiello B, Wells K, Wigal T (2001b) Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): implications and applications for primary care providers. J Dev Behav Pediatr 22(1):60–73

    CAS  PubMed  Google Scholar 

  • Jummani R, Coffey B (2015) ADHD and tic disorders. In: Adler L, Spencer T, Wilens T (eds) Attention-deficit hyperactivity disorder in adults and children. Cambridge University Press, Cambridge, pp 343–352

    Google Scholar 

  • Kamp CF, Sperlich B, Holmberg HC (2014) Exercise reduces the symptoms of attention-deficit/hyperactivity disorder and improves social behaviour, motor skills, strength and neuropsychological parameters. Acta Paediatr 103(7):709–714. doi:10.1111/apa.12628

    PubMed  Google Scholar 

  • Kashyap H, Fontenelle LF, Miguel EC, Ferrão YA, Torres AR, Shavitt RG, Ferreira-Garcia R, do Rosario M, Yücel M (2012) ‘Impulsive compulsivity’ in obsessive-compulsive disorder: a phenotypic marker of patients with poor clinical outcome. J Psychiatr Res 46(9):1146–1152

    PubMed  Google Scholar 

  • Kesner RP, Churchwell JC (2011) An analysis of rat prefrontal cortex in mediating executive function. Neurobiol Learn Mem 96(3):417–431

    PubMed  Google Scholar 

  • Kessler RC, Adler LA, Barkley R, Biederman J, Conners CK, Greenhill LL, Spencer T (2011) The prevalence and correlates of adult ADHD. In: Buitelaar JK, Kan CC, Asherson P (eds) ADHD in adults: characterization, diagnosis, and treatment. Cambridge University Press, Cambridge, pp 9–17

    Google Scholar 

  • Konrad K, Neufang S, Hanisch C, Fink GR, Herpertz-Dahlmann B (2006) Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: evidence from an event-related functional magnetic resonance imaging study. Biol Psychiatry 59(7):643–651

    PubMed  Google Scholar 

  • Koziol LF, Budding D (2012) Requiem for a diagnosis: attention-deficit hyperactivity disorder. Appl Neuropsychol Child 1(1):2–5

    PubMed  Google Scholar 

  • Kuczenski R, Segal DS (1997) Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine. J Neurochem 68(5):2032–2037

    CAS  PubMed  Google Scholar 

  • Lahey BB, Schaughency EA, Hynd GW, Carlson CL, Nieves N (1987) Attention deficit disorder with and without hyperactivity: comparison of behavioral characteristics of clinic-referred children. J Am Acad Child Adolesc Psychiatry 26(5):718–723

    CAS  PubMed  Google Scholar 

  • Lahey BB, Pelham WE, Loney J, Lee SS, Willcutt E (2005) Instability of the DSM- IV subtypes of ADHD from preschool through elementary school. Arch Gen Psychiatry 62:896–902

    PubMed  Google Scholar 

  • Lange K, Reichl S, Lange K, Tucha L, Tucha O (2010) The history of attention deficit hyperactivity disorder. ADHD 2(4):241–255

    PubMed Central  PubMed  Google Scholar 

  • Lee S, Burns GL, Snell J, McBurnett K (2014) Validity of the sluggish cognitive tempo symptom dimension in children: sluggish cognitive tempo and ADHD-inattention as distinct symptom dimensions. J Abnorm Child Psychol 42(1):7–19

    PubMed  Google Scholar 

  • Lensing MB, Zeiner P, Sandvik L, Opjordsmoen S (2013) Adults with ADHD: use and misuse of stimulant medication as reported by patients and their primary care physicians. ADHD 5(4):369–376

    PubMed  Google Scholar 

  • Leth-Steensen C, King Elbaz Z, Douglas VI (2000) Mean response times, variability, and skew in the responding of ADHD children: a response time distributional approach. Acta Psychol 104(2):167–190

    CAS  Google Scholar 

  • Li F, He N, Li Y, Chen L, Huang X, Lui S, Guo L, Kemp GJ, Gong Q (2014) Intrinsic brain abnormalities in attention deficit hyperactivity disorder: a resting- state functional MR imaging study. Radiology 272(2):514–523. doi:10.1148/radiol.14131622

    PubMed  Google Scholar 

  • Lim L, Chantiluke K, Cubillo AI, Smith AB, Simmons A, Mehta MA, Rubia K (2015) Disorder-specific grey matter deficits in attention deficit hyperactivity disorder relative to autism spectrum disorder. Psychol Med 45(5):965–976. doi:10.1017/S0033291714001974

    PubMed Central  CAS  PubMed  Google Scholar 

  • Linssen AMW, Sambeth A, Vuurman EFPM, Riedel WJ (2014) Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies. Int J Neuropsychopharmacol 17(6):961–977

    CAS  PubMed  Google Scholar 

  • Lockwood KA, Marcotte AC, Stern C (2001) Differentiation of attention- deficit/hyperactivity disorder subtypes: application of a neuropsychological model of attention. J Clin Exp Neuropsychol 23(3):317–330

    CAS  PubMed  Google Scholar 

  • Lopez-Vergara HI, Colder CR (2013) An examination of the specificity of motivation and executive functioning in ADHD symptom-clusters in adolescence. J Pediatr Psychol 38(10):1081–1090

    PubMed Central  PubMed  Google Scholar 

  • Lynam DR (1996) The early identification of chronic offenders: who is the fledgling psychopath? Psychol Bull 120:209–234

    CAS  PubMed  Google Scholar 

  • Marsh PJ, Williams LM (2006) ADHD and schizophrenia phenomenology: visual scanpaths to emotional faces as a potential psychophysiological marker? Neurosci Biobehav Rev 30(5):651–665

    PubMed  Google Scholar 

  • Massat I, Slama H, Kavec M, Linotte S, Mary A, Baleriaux D, Metens T, Mendlewicz J, Peigneux P (2012) Working memory-related functional brain patterns in never medicated children with ADHD. PLoS ONE 7(11):e49392

    PubMed Central  CAS  PubMed  Google Scholar 

  • Mattfeld AT, Gabrieli JD, Biederman J, Spencer T, Brown A, Kotte A, Kagan E, Whitfield-Gabrieli S (2014) Brain differences between persistent and remitted attention deficit hyperactivity disorder. Brain 137(Pt 9):2423–2428. doi:10.1093/brain/awu137

    PubMed  Google Scholar 

  • Matthews M, Nigg JT, Fair DA (2014) Attention deficit hyperactivity disorder. Curr Topics Behav Neurosci 2014(16):235–266

    Google Scholar 

  • McBurnett K, Pfiffner LJ, Frick PJ (2001) Symptom properties as a function of ADHD type: an argument for continued study of sluggish cognitive tempo. J Abnorm Child Psychol 29(3):207–213

    CAS  PubMed  Google Scholar 

  • McLaughlin KA, Sheridan MA, Winter W, Fox NA, Zeanah CH, Nelson CA (2014) Widespread reductions in cortical thickness following severe early-life deprivation: a neurodevelopmental pathway to attention-deficit/hyperactivity disorder. Biol Psychiatry 76(8):629–638

    PubMed Central  PubMed  Google Scholar 

  • Mikami AY, Jia M, Na JJ (2014) Social skills training. Child Adolesc Psychiatr Clin N Am 23(4):775–788

    PubMed  Google Scholar 

  • Milich R, Balentine AC, Lynam DR (2001) ADHD combined type and ADHD predominantly inattentive type are distinct and unrelated disorders. Clin Psychol Sci Pract 8(4):463–488

    Google Scholar 

  • Millichap JG, Yee MM (2012) The diet factor in attention-deficit/hyperactivity disorder. Pediatrics 129(2):330–337

    PubMed  Google Scholar 

  • Mills KL, Bathula D, Dias TGC, Iyer SP, Fenesy MC, Musser ED, Stevens CA, Thurlow BL, Carpenter SD, Nagel BJ, Nigg JT, Fair DA (2012) Altered cortico-striatal–thalamic connectivity in relation to spatial working memory capacity in children with ADHD. Front Psychiatry 3:2. doi:10.3389/fpsyt.2012.00002

    PubMed Central  PubMed  Google Scholar 

  • Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD (2000) The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis. Cogn Psychol 41(1):49–100

    CAS  PubMed  Google Scholar 

  • Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC (2014) Psychiatric aspects of impulsivity. Amer J Psychiatry 158(11):1783–1793

    Google Scholar 

  • Mostofsky S, Simmonds D (2008) Response inhibition and response selection: two sides of the same coin. J Cogn Neurosci 20(5):751–761

    PubMed  Google Scholar 

  • Mostofsky SH, Schafer JG, Abrams MT, Goldberg MC, Flower AA, Boyce A, Courtney SM, Calhoun VD, Kraut MA, Denckla MB, Pekar JJ (2003) fMRI evidence that the neural basis of response inhibition is task-dependent. Cogn Brain Res 17(2):419–430

    Google Scholar 

  • MTA Cooperative Group (1999) A 14-month randomized clinical trial of treatment strategies For attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 56:1073–1086

    Google Scholar 

  • Nakao T, Radua C, Rubia K, Mataix-Cols D (2011) Gray matter volume abnormalities in ADHD and the effects of stimulant medication: voxel-based meta-analysis. Am J Psychiatry 168(11):1154–1163

    PubMed  Google Scholar 

  • Nigg JT, Blaskey LG, Huang-Pollock CL, Rappley MD (2002) Neuropsychological executive functions and DSM-IV ADHD subtypes. J Am Acad Child Adolesc Psychiatry 41(1):59–66

    PubMed  Google Scholar 

  • Nigg JT, Willcutt EG, Doyle AE, Sonuga-Barke EJ (2005) Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry 57(11):1224–1230

    PubMed  Google Scholar 

  • Nigg JT, Lewis K, Edinger T, Falk M (2012) Meta-analysis of attention- deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry 51(1):86–97

    PubMed Central  PubMed  Google Scholar 

  • Ollendorf DA, Migliaccio-Walle K, Colby JA, Pearson SD (2013) Management options for children with attention-deficit/hyperactivity disorder: a regional perspective on value. J Comp Eff Res 2(3):261–271

    PubMed  Google Scholar 

  • Patel N, Patel M, Patel H (2012) ADHD and comorbid conditions. Atten Deficit Hyperact Disord 1:978–979

    Google Scholar 

  • Pelham WE Jr, Fabiano GA (2008) Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. J Clin Child Adolesc Psychol 37(1):184–214

    PubMed  Google Scholar 

  • Pliszka SR (2015) ADHD and tic disorders. In: Adler L, Spencer T, Wilens T (eds) Attention-deficit hyperactivity disorder in adults and children. Cambridge University Press, Cambridge, pp 63–71

    Google Scholar 

  • Pliszka SR, Carlson CL, Swanson JM (1999) ADHD with comorbid disorders: clinical assessment and management. Guilford Press, Newyork

    Google Scholar 

  • Polanczyk GV, Willcutt EG, Salum GA, Kieling C, Rohde LA (2014) ADHD prevalence estimates across three decades: an updated systematic review and meta- regression analysis. Int J Epidemiol 43(2):434–442

    PubMed  Google Scholar 

  • Posner MI, Petersen SE (1989) The attention system of the human brain (No. TR-89-1). Washington Univ ST Louis MO Dept of Neurology

  • Quinn CA (2003) Detection of malingering in assessment of adult ADHD. Arch Clin Neuropsychol 18(4):379–395

    PubMed  Google Scholar 

  • Rabiner DL (2013) Stimulant prescription cautions: addressing misuse, diversion and malingering. Curr Psychiatry Rep 15(7):1–8

    Google Scholar 

  • Rapport MD, Denney C, DuPaul GJ, Gardner MJ (1994) Attention deficit disorder and methylphenidate: normalization rates, clinical effectiveness, and response prediction in 76 children. J Am Acad Child Adolesc Psychiatry 33(6):882–893

    CAS  PubMed  Google Scholar 

  • Reddy LF, Lee J, Davis MC, Altshuler L, Glahn DC, Milowitz DJ, Green MF (2014) Impulsivity and risk taking in bipolar disorder and schizophrenia. Neuropsychopharmacology 39(2):456–463

    PubMed Central  PubMed  Google Scholar 

  • Riccio CA, Homack S, Jarratt KP, Wolfe ME (2006) Differences in academic and executive function domains among children with ADHD predominantly inattentive and combined types. Arch Clin Neuropsychol 21(7):657–667

    PubMed  Google Scholar 

  • Rosa-Neto P, Lou HC, Cumming P, Pryds O, Karrebaek H, Lunding J, Gjedde A (2005) Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder. Neuroimage 25(3):868–876

    PubMed  Google Scholar 

  • Rubia K, Smith AB, Brammer MJ, Toone B, Taylor E (2005) Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD. Am J Psychiatry 162(6):1067–1075

    PubMed  Google Scholar 

  • Rubia K, Halari R, Cubillo A, Mohammad AM, Brammer M, Taylor E (2009) Methylphenidate normalises activation and functional connectivity deficits in attention and motivation networks in medication-naive children with ADHD during a rewarded continuous performance task. Neuropharmacology 57(7):640–652

    CAS  PubMed  Google Scholar 

  • Rubia K, Cubillo A, Smith AB, Woolley J, Heyman I, Brammer MJ (2010) Disorder-specific dysfunction in right inferior prefrontal cortex during two inhibition tasks in boys with attention-deficit hyperactivity disorder compared to boys with obsessive–compulsive disorder. Hum Brain Mapp 31(2):287–299

    PubMed  Google Scholar 

  • Rubia K, Cubillo A, Woolley J, Brammer MJ, Smith A (2011) Disorder-specific dysfunctions in patients with attention-deficit/hyperactivity disorder compared to patients with obsessive-compulsive disorder during interference inhibition and attention allocation. Hum Brain Mapp 32(4):601–611

    PubMed  Google Scholar 

  • Rubia K, Alegria AA, Cubillo AI, Smith AB, Brammer MJ, Radua J (2014a) Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Biol Psychiatry 76(8):616–628

    PubMed Central  CAS  PubMed  Google Scholar 

  • Rubia K, Alegria A, Brinson H (2014b) Imaging the ADHD brain: disorder-specificity, medication effects and clinical translation. Exp Rev Neurother 0:1–20

    Google Scholar 

  • Saxbe C, Barkley RA (2014) The second attention disorder? Sluggish cognitive tempo vs. attention-deficit/hyperactivity disorder: update for clinicians. J Psychiatr Pract 20(1):38–49

    PubMed  Google Scholar 

  • Schaeffer JL, Ross RG (2002) Childhood-onset schizophrenia: premorbid and prodromal diagnostic and treatment histories. J Am Acad Child Adolesc Psychiatry 41(5):538–545

    PubMed  Google Scholar 

  • Schmeichel BE, Berridge CW (2013) Neurocircuitry underlying the preferential sensitivity of prefrontal catecholamines to low-dose psychostimulants. Neuropsychopharmacology 38(6):1078–1084

    PubMed Central  CAS  PubMed  Google Scholar 

  • Sciutto MJ, Eisenberg M (2007) Evaluating the evidence for and against the overdiagnosis of ADHD. J Atten Disord 11(2):106–113

    PubMed  Google Scholar 

  • Sebastian A, Jung P, Krause-Utz A, Lieb K, Schmahl C, Tüscher O (2014) Frontal dysfunctions of impulse control–a systematic review in borderline personality disorder and attention-deficit/hyperactivity disorder. Front Hum Neurosci 8:698. doi:10.3389/fnhum.2014.00698

    PubMed Central  PubMed  Google Scholar 

  • Segal DS, Kuczenski R (1994) Behavioral pharmacology of amphetamine. Amphetamine and its analogs: psychopharmacology, toxicology and abuse. San Diego, Academic Press, Inc., 115–150

  • Shalev L, Tsal Y (2003) The wide attentional window a major deficit of children with attention difficulties. J Learn Disabil 36(6):517–527

    PubMed  Google Scholar 

  • Shallice T, Burgess P (1991) Higher-order cognitive impairments and frontal lobe lesions in man. In: Levin HS, Eisenberg HM, Benton AL (eds) Frontal lobe function and dysfunction. Oxford University Press, Oxford, New York, pp 125–138

    Google Scholar 

  • Shaw P, Eckstrand K, Sharp W, Blumenthal J, Lerch JP, Greenstein D, Clasen L, Evans A, Giedd J, Rapoport JL (2007) Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci 104(49):19649–19654

    PubMed Central  CAS  PubMed  Google Scholar 

  • Shaw P, Malek M, Watson B, Greenstein D, de Rossi P, Sharp W (2013) Trajectories of cerebral cortical development in childhood and adolescence and adult attention- deficit/hyperactivity disorder. Biol Psychiatry 74(8):599–606

    PubMed  Google Scholar 

  • Sibley MH, Altszuler AR, Morrow AS, Merrill BM (2014) Mapping the academic problem behaviors of adolescents with ADHD. Sch Psychol Q 29(4):422

    PubMed  Google Scholar 

  • Simmonds DJ, Pekar JJ, Mostofsky SH (2008) Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task- dependent. Neuropsychologia 46(1):224–232

    PubMed Central  PubMed  Google Scholar 

  • Skogli EW, Teicher MH, Andersen PN, Hovik KT, Øie M (2013) ADHD in girls and boys–gender differences in co-existing symptoms and executive function measures. BMC Psychiatry 13(1):298

    PubMed Central  PubMed  Google Scholar 

  • Smith A, Taylor E, Brammer M, Toone B, Rubia K (2006) Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder. Am J Psychiatry 163(6):1044–1051

    PubMed  Google Scholar 

  • Solanto M, Newcorn J, Vail L, Gilbert S, Ivanov I, Lara R (2009) Stimulant drug response in the predominantly inattentive and combined subtypes of attention- deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 19(6):663–671

    PubMed Central  PubMed  Google Scholar 

  • Song Y, Hakoda Y (2014) Executive and non-executive functions in attention deficit hyperactivity disorder of the inattentive type (ADHD-I): a cognitive profile. J Behav Brain Sci 4:1–10

    Google Scholar 

  • Sonuga-Barke EJ (2002) Psychological heterogeneity in AD/HD—a dual pathway model of behaviour and cognition. Behav Brain Res 130(1):29–36

    PubMed  Google Scholar 

  • Sonuga-Barke EJ, Brandeis D, Cortese S, Daley D, Ferrin M, Holtmann M, Stevenson J, Danckaerts M, van der Oord S, Döpfner M, Dittmann RW, Simonoff E, Zuddas A, Banaschewski T, Buitelaar J, Coghill D, Hollis C, Konofal E, Lecendreux M, Wong ICK, Sergeant J (2013) Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. Am J Psychiatry 170(3):275–289

    PubMed  Google Scholar 

  • Sonuga-Barke E, Brandeis D, Holtmann M, Cortese S (2014) Computer-based cognitive training for ADHD: a review of current evidence. Child Adolesc Psychiatr Clin N Am 23(4):807–824

    PubMed  Google Scholar 

  • Sripada CS, Kessler D, Angstadt M (2014) Lag in maturation of the brain’s intrinsic functional architecture in attention-deficit/hyperactivity disorder. Proc Natl Acad Sci 111(39):14259–14264

    PubMed Central  CAS  PubMed  Google Scholar 

  • Stevenson J, Buitelaar J, Cortese S, Ferrin M, Konofal E, Lecendreux M, Simonoff E, Wong CK, Sonuga-Barke E (2014) Research review: the role of diet in the treatment of attention- deficit/hyperactivity disorder–an appraisal of the evidence on efficacy and recommendations on the design of future studies. J Child Psychol Psychiatry 55(5):416–427

    PubMed  Google Scholar 

  • Stuss DT, Benson DF (1986) The frontal lobes. Raven, New York

    Google Scholar 

  • Stuss DT, Floden D, Alexander MP, Levine B, Katz D (2001) Stroop performance in focal lesion patients: dissociation of processes and frontal lobe lesion location. Neuropsychologia 39(8):771–786

    CAS  PubMed  Google Scholar 

  • Tarver J, Daley D, Sayal K (2014) Attention-deficit hyperactivity disorder (ADHD): an updated review of the essential facts. Child Care Health Dev 40(6):762–774. doi:10.1111/cch.12139

    CAS  PubMed  Google Scholar 

  • Taylor E (2011) Antecedents of ADHD: a historical account of diagnostic concepts. ADHD 3(2):69–75

    PubMed  Google Scholar 

  • Tian L, Jiang T, Liang M, Zang Y, He Y, Sui M, Wang Y (2008) Enhanced resting- state brain activities in ADHD patients: a fMRI study. Brain Dev 30(5):342–348

    PubMed  Google Scholar 

  • Timimi S (2004) Developing nontoxic approaches to helping children who could be diagnosed with ADHD and their families: reflections of a United Kingdom Clinician. Ethical Hum Sci Serv 6(1):41–52

    Google Scholar 

  • Tomasi D, Volkow ND (2012) Abnormal functional connectivity in children with attention-deficit/hyperactivity disorder. Biol Psychiatry 71(5):443–450

    PubMed Central  PubMed  Google Scholar 

  • Tucha L, Fuermaier AB, Koerts J, Groen Y, Thome J (2014) Detection of feigned attention deficit hyperactivity disorder. J Neural Transm 1–12. doi:10.1007/s00702-014-1274-3

  • Valera EM, Faraone SV, Murray KE, Seidman LJ (2007) Meta-analysis of structural imaging findings in attention-deficit/hyperactivity disorder. Biol Psychiatry 61(12):1361–1369

    PubMed  Google Scholar 

  • Valera EM, Brown A, Biederman J, Faraone SV, Makris N, Monuteaux MC, Whitfield-Gabrielli S, Vitulano M, Schiller M, Seidman LJ (2010) Sex differences in the functional neuroanatomy of working memory in adults with ADHD. Am J Psychiatry 167(1):86–94

    PubMed Central  PubMed  Google Scholar 

  • van Lieshout M, Luman M, Buitelaar J, Rommelse NNJ, Oosterlaan J (2013) Does neurocognitive functioning predict future or persistence of ADHD? Syst Rev Clin Psychol Rev 33(4):539–560

    Google Scholar 

  • Visser SN, Danielson ML, Bitsko RH, Holbrook JR, Kogan MD, Ghandour RM, Perous R, Blumberg SJ (2014) Trends in the parent-report of health care provider- diagnosed and medicated attention-deficit/hyperactivity disorder: United States, 2003–2011. J Am Acad Child Adolesc Psychiatry 53(1):34–46

    PubMed Central  PubMed  Google Scholar 

  • Vitiello B (2001) Long-term effects of stimulant medications on the brain: possible relevance to the treatment of attention deficit hyperactivity disorder. J Child Adolesc Psychopharmacol 11(1):25–34

    CAS  PubMed  Google Scholar 

  • Volkow ND, Insel TR (2003) What are the long-term effects of methylphenidate treatment? Biol Psychiatry 54(12):1307–1309

    PubMed  Google Scholar 

  • Volkow ND, Swanson JM (2013) Adult attention deficit-hyperactivity disorder. N Engl J Med 369(20):1935–1944

    CAS  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Logan J, Ding YS, Hitzemann R, Pappas N (1998) Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate. Am J Psychiatry 155(10):1325–1331

    CAS  PubMed  Google Scholar 

  • Volkow ND, Fowler JS, Wang GJ, Baler R, Telang F (2009) Imaging dopamine’s role in drug abuse and addiction. Neuropharmacology 56:3–8

    PubMed Central  CAS  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Newcorn JH, Kollins SH, Wigal TL, Telang F, Fowler JS, Goldstein RZ, Klein N, Logan J, Wong C, Swanson JM (2011) Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. Mol Psychiatry 16(11):1147–1154

    PubMed Central  CAS  PubMed  Google Scholar 

  • Wåhlstedt C, Thorell LB, Bohlin G (2009) Heterogeneity in ADHD: neuropsychological pathways, comorbidity and symptom domains. J Abnorm Child Psychol 37(4):551–564

    PubMed  Google Scholar 

  • Wasserman RC, Kelleher KJ, Bocian A, Baker A, Childs GE, Indacochea F, Stulp C, Gardner WP (1999) Identification of attentional and hyperactivity problems in primary care: a report from pediatric research in office settings and the ambulatory sentinel practice network. Pediatrics 103(3):e38

    CAS  PubMed  Google Scholar 

  • Weiss M, Worling D, Wasdell M (2003) A chart review study of the inattentive and combined types of ADHD. J Atten Disord 7(1):1–9

    CAS  PubMed  Google Scholar 

  • Wilens TE, Morrison NR (2011) The intersection of attention-deficit/hyperactivity disorder and substance abuse. Curr Opin Psychiatry 24(4):280

    PubMed Central  PubMed  Google Scholar 

  • Wilens TE, Biederman J, Forkner P, Ditterline J, Morris M, Moore H, Galdo M, Spencer TJ, Wozniak J (2003) Patterns of comorbidity and dysfunction in clinically referred preschool and school-age children with bipolar disorder. J Child Adolesc Psychopharmacol 13(4):495–505

    PubMed  Google Scholar 

  • Wilkinson D, Halligan P (2004) The relevance of behavioural measures for functional- imaging studies of cognition. Nat Rev Neurosci 5(1):67–73

    CAS  PubMed  Google Scholar 

  • Willcutt EG (2012) The prevalence of DSM-IV attention-deficit/hyperactivity disorder: a meta-analytic review. Neurotherapeutics 9(3):490–499

    PubMed Central  PubMed  Google Scholar 

  • Williamson KD, Combs HL, Berry DT, Harp JP, Mason LH, Edmundson M (2014) Discriminating among ADHD alone, ADHD with a comorbid psychological disorder, and feigned ADHD in a college sample. Clin Neuropsychol 28(7):1182–1196

    PubMed  Google Scholar 

  • Willoughby MT (2003) Developmental course of ADHD symptomatology during the transition from childhood to adolescence: a review with recommendations. J Child Psychol Psychiatry 44(1):88–106

    PubMed  Google Scholar 

  • Wolraich ML (2006) Attention-deficit/hyperactivity disorder: can it be recognized and treated in children younger than 5 years? Infants Young Child 19(2):86–93

    Google Scholar 

  • Wolraich M, Milich R, Stumbo P, Schultz F (1985) Effects of sucrose ingestion on the behavior of hyperactive boys. J Pediatr 106(4):675–682

    CAS  PubMed  Google Scholar 

  • Wolraich ML, Lindgren SD, Stumbo PJ, Stegink LD, Appelbaum MI, Kiritsy MC (1994) Effects of diets high in sucrose or aspartame on the behavior and cognitive performance of children. N Engl J Med 330(5):301–307

    CAS  PubMed  Google Scholar 

  • Wolraich ML, McKeown RE, Visser SN, Bard D, Cuffe S, Neas B, Geryk LL, Doffing M, Bottsi M, Abramowitz AJ, Beck L, Holbrook JR, Danielson M (2014) the prevalence of ADHD: its diagnosis and treatment in four school districts across two states. J Atten Disord 18(7):563–575

    PubMed  Google Scholar 

  • Yu-Feng Z, Yong H, Chao-Zhe Z, Qing-Jiu C, Man-Qiu S, Meng L, Li-Xia T, Tian-Zi J, Yu-Feng W (2007) Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI. Brain Dev 29(2):83–91

    Google Scholar 

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Heidbreder, R. ADHD symptomatology is best conceptualized as a spectrum: a dimensional versus unitary approach to diagnosis. ADHD Atten Def Hyp Disord 7, 249–269 (2015). https://doi.org/10.1007/s12402-015-0171-4

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