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Short-term repeatability of myocardial blood flow using 82Rb PET/CT: The effect of arterial input function position and motion correction

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

We tested the repeatability of myocardial blood flow (MBF) quantified using 82Rb with and without motion correction (MC) and with arterial input functions estimated from left ventricle (LV) and atrium (LA).

Methods

Twenty-one patients referred for clinical 82Rb PET/CT underwent repeated rest scans in a single imaging session. Global MBF was quantified using three different assessments by two operators: (1) automatic processing without MC and LV arterial input function (AIF), (2) with MC and LV-AIF, and (3) with MC and LA-AIF. Inter-scan and inter-operator repeatability were tested using coefficient of variation (CV).

Results

MC with LV-AIF did not change MBF (no MC: 1.01 ± 0.30 mL/min/g vs MC with LV-AIF: 1.01 ± 0.29, P = 0.70), whereas MC with LA-AIF showed significantly lower MBF assessments (0.95 ± 0.28 mL/min/g, P = 0.0006). We report significant improvement for test-retest reproducibility for global MBF following MC (CV; No MC: 16.0, MC (LV-AIF): 9.2, MC (LA-AIF): 8.8). Good inter-operator repeatability was observed for LV-AIF (CV = 4.7) and LA-AIF (CV = 5.6) for global MBF assessments.

Conclusions

MC significantly improved the test-retest repeatability between operators and between scans. MBF obtained after MC with LV-AIF were comparable, whereas MBFs after MC and LA-AIF were significantly reduced.

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Abbreviations

AIF:

Arterial input function

CAD:

Coronary artery disease

LA:

Left atrium

LV:

Left ventricle

MBF:

Myocardial blood flow

ROI:

Region of interest

RPC:

Repeatability coefficient

82Rb:

Rubidium-82

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Disclosure

D. S. Berman and P. J. Slomka receive software royalties from QPS software at Cedars-Sinai Medical Center. Y. Otaki, M. L. Lassen, O. Manabe, E. Eisenberg, H. Gransar, F. Wang, Y. J. Lee, and E. Tzoloz declare that they have no conflict of interest.

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Author notes

  1. Yuka Otaki and Martin Lyngby Lassen contributed equally to this article.

Authors and Affiliations

  1. Department of Imaging and Medicine, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Ste. A047N, Los Angeles, CA, 90048, USA

    Yuka Otaki MD, PhD, Martin Lyngby Lassen PhD, Osamu Manabe MD, PhD, Evann Eisenberg MD, Heidi Gransar MS, Frances Wang MS, Yoon Jae Lee MS, Evangelos Tzolos MD, Daniel S. Berman MD & Piotr J. Slomka PhD

  2. Department of Nuclear Medicine, Hokkaido University of Graduate School of Medicine, Sapporo, Japan

    Osamu Manabe MD, PhD

  3. Centre for Cardiovascular Sciences, University of Edinburgh, Chancellors Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK

    Evangelos Tzolos MD

Authors
  1. Yuka Otaki MD, PhD
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  2. Martin Lyngby Lassen PhD
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  3. Osamu Manabe MD, PhD
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  4. Evann Eisenberg MD
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  5. Heidi Gransar MS
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  6. Frances Wang MS
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  7. Yoon Jae Lee MS
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  8. Evangelos Tzolos MD
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  9. Daniel S. Berman MD
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  10. Piotr J. Slomka PhD
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Corresponding author

Correspondence to Piotr J. Slomka PhD.

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Otaki, Y., Lassen, M.L., Manabe, O. et al. Short-term repeatability of myocardial blood flow using 82Rb PET/CT: The effect of arterial input function position and motion correction. J. Nucl. Cardiol. 28, 1718–1725 (2021). https://doi.org/10.1007/s12350-019-01888-5

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  • DOI: https://doi.org/10.1007/s12350-019-01888-5

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