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Left ventricular mechanical dyssynchrony assessment in long-standing type II diabetes mellitus patients with normal gated SPECT-MPI

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Assessment of left ventricular mechanical dyssynchrony (LVMD) using phase analysis of gated SPECT-MPI is well established. However, there is little information about the influence of diabetes mellitus on phase analysis. The present work was to evaluate the LVMD in longstanding type II diabetes mellitus (DM) patients with normal gated SPECT-MPI.

Methods

Retrospective analysis of 146 (86 type II diabetics for > 5 years’ duration and 60 nondiabetics) consecutive patients with normal gated SPECT-MPI and adequate LVEF was done. Sixty age- and sex-matched nondiabetic served as control. LVMD was determined from the cutoff values (> mean + 2 SD) observed for phase standard deviation (PSD) and phase bandwidth (PBW) from the control subjects. Multivariate logistic regression analysis was applied to assess the correlation between various confounding factors.

Results

LVMD was detected in 24 (28%) diabetic patients with the pre-defined cut-off values for PSD (> 10.8) and PBW (> 35.6) derived from the controls. Hyperlipidemia, overweight/obesity, duration of DM and its long-term complications were independently associated with LVMD, with long-term complications being the highest risk factor (OR 28.00; P < .001).

Conclusion

The evolution time of the patients with type II diabetes mellitus affects the left ventricular mechanical synchrony.

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Abbreviations

LVMD:

Left ventricular mechanical dyssynchrony

DM:

Diabetes mellitus

PSD:

Phase standard deviation

PBW:

Phase bandwidth

DCM:

Diabetic cardiomyopathy

TDI:

Tissue Doppler imaging

LVEF:

Left ventricle ejection fraction

SPECT-MPI:

Single-photon emission computed tomography myocardial perfusion imaging

CRT:

Cardiac resynchronization therapy

LVD:

Left ventricular dyssynchrony

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Disclosure

There is no potential conflict of interest to disclose.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

    Dharmender Malik DNB, Bhagwant Mittal MD, DNB, Ashwani Sood DNB, Madan Parmar Msc & Gurvinder Kaur Msc

  2. Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

    Ajay Bahl DM

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  1. Dharmender Malik DNB
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  2. Bhagwant Mittal MD, DNB
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Correspondence to Ashwani Sood DNB.

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Malik, D., Mittal, B., Sood, A. et al. Left ventricular mechanical dyssynchrony assessment in long-standing type II diabetes mellitus patients with normal gated SPECT-MPI. J. Nucl. Cardiol. 26, 1650–1658 (2019). https://doi.org/10.1007/s12350-018-1208-9

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  • DOI: https://doi.org/10.1007/s12350-018-1208-9

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