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Comprehensive review on cardio-oncology: Role of multimodality imaging

  • Review Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Cancer and cardiovascular disease are the two leading causes of mortality worldwide. Evolving oncologic therapy, including the use of newer targeted agents, has led to an improvement in survival from childhood- and adult-onset cancers. Consequently, there has been a growing realization of cardiotoxic complications related to cancer therapy, with some complications manifesting over months to decades after completion of cancer treatment. This paper reviews cancer therapeutics-related cardiovascular toxicity and its manifestations, multimodality imaging techniques for surveillance and detection of this complication, and the current state of knowledge in this emerging field.

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Abbreviations

2DE:

2D echocardiography

3DE:

3D echocardiography

ASE:

American Society of Echocardiography

ARB:

Angiotensin receptor blocker

ACEI:

Angiotensin-converting enzyme inhibitor

CTRCD:

Cancer therapeutics–related cardiac dysfunction

CT:

Cardiac computed tomography

CMRi:

Cardiac magnetic resonance imaging

CV:

Cardiovascular

CAD:

Coronary artery disease

EF:

Ejection fraction

HER2:

Epidermal growth factor receptor type 2

EACVI:

European Association of Cardiovascular Imaging

FGFRS:

Fibroblast growth factor receptors

FMRI:

Functional magnetic resonance imaging

GLS:

Global longitudinal strain

GFR:

Glomerular Filtration Rate

HF:

Heart failure

HGFRS:

Hepatocyte growth factor receptors

HER2 or erbb2:

Human epidermal growth factor receptor 2

IR:

Insulin growth factor receptors

IGFR:

Insulin-like growth factor receptors

IMT:

Intima-media thickness

LV:

Left ventricular/left ventricle

MUGA:

Multi-gated acquisition with blood pool imaging

MI:

Myocardial infarction

PDGFRS:

Platelet-derived growth factor receptors

PET:

Positron emission tomography

SPECT:

Single photon emission computed tomography

SCAI:

Society for Cardiovascular Angiography and Interventions

STE:

Speckle-tracking echocardiography

TDI:

Tissue Doppler imaging

TIA:

Transient ischemic attack

VEGF:

Vascular endothelial growth factor

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    Authors and Affiliations

    1. Birmingham Veterans Affairs Medical Center, University of Alabama at Birmingham, Birmingham, Alabama, USA

      Carol Chen-Scarabelli PhD, Massoud A. Leesar MD, Fadi G. Hage MD & Tiziano M. Scarabelli MD, PhD

    2. Division of Cardiovascular Disease, University of Alabama at Birmingham, 1530 3rd Avenue, South Tinsley Harrison Tower, Birmingham, Alabama, 35294-0006, USA

      Chad McRee MD, Massoud A. Leesar MD, Fadi G. Hage MD & Tiziano M. Scarabelli MD, PhD

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    An audio interview was held April 26, 2016 between the Editor-in-Chief, Ami E. Iskandrian, and Tiziano M. Scarabelli, discussing the content of this review article. An audio file of the interview is available as an .mp3 download at this article’s webpage on SpringerLink.com; the transcript of the interview can be found at https://doi.org/10.1007/s12350-016-0536-x.

    Carol Chen-Scarabelli and Chad McRee have contributed equally to the writing of the manuscript.

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    Chen-Scarabelli, C., McRee, C., Leesar, M.A. et al. Comprehensive review on cardio-oncology: Role of multimodality imaging. J. Nucl. Cardiol. 24, 906–935 (2017). https://doi.org/10.1007/s12350-016-0535-y

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