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A study to quantify the effect of patient motion and develop methods to detect and correct for motion during myocardial perfusion imaging on a CZT solid-state dedicated cardiac camera

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Due to differences in the design and acquisition parameters on the solid-state CZT cardiac camera the effect of patient motion may vary compared to Anger cameras. This study evaluates the effect of motion, two new methods of three-dimensional (3D) motion detection and a method of motion correction.

Method

Phantom acquisitions were offset in the X, Y, and Z directions and combined to simulate different types of motion. Motion artifacts were identified using the total perfusion defect and blinded visual interpretation. Motion was detected by registering planar and reconstructed 30 second images, and corrected by summing the aligned reconstructed images. Validation was performed on phantom data. These techniques were then applied to 40 patient studies.

Results

Motion ≥10 mm and ≥60 seconds in duration introduced significant artifacts. There was no significant difference (P = .258) between the two methods of motion detection. Motion correction removed artifacts from 9/10 phantom simulations. Superior-inferior motion ≥8 mm was measured on 10% of patient studies, and 5% were affected by motion. Motion in the lateral and anterior-posterior directions was <8 mm.

Conclusion

Superior-inferior patient motion artifacts have been identified on myocardial perfusion images acquired on a CZT camera. Routine QC to identify studies with significant motion is recommended.

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Abbreviations

CZT:

Cadmium-zinc-telluride

TPD:

Total perfusion defect

MPI:

Myocardial perfusion imaging

QFOV:

Quality field of view

ShIRT:

Sheffield image registration toolkit

Tc99m :

Technetium-99m

EANM:

European Association of Nuclear Medicine

SNM:

Society of Nuclear Medicine

QPS:

Quantitative perfusion SPECT

MIBI:

Methoxyisobutylisonitrile

CAD:

Coronary artery disease

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Acknowledgments

This article is independent research arising from a NIHR/CSO Healthcare Scientist Doctoral Research Fellowship supported by the National Institute for Health Research. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health.

Disclosures

S. Redgate reports funding received under a NIHR/CSO Healthcare Scientist Doctoral Research Fellowship supported by the National Institute for Health Research, in relation to this study. Dr Al-Mohammad reports other support from Servier, outside the submitted work. Prof. Tindale reports funding from the National Institute for Health Research, in her capacity as a Director of NIHR Devices for Dignity Healthcare Technology Co-operative, outside the submitted work. Prof Barber, Dr Fenner, Mr Taylor, and Mr Hanney, have nothing to disclose.

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Authors and Affiliations

  1. Nuclear Medicine Department, Sheffield Teaching Hospitals NHS Foundation Trust, I-Floor, Royal Hallamshire Hospital, Glossop Rd, Sheffield, S10 2JF, United Kingdom

    Shelley Redgate BSc, MSc, Jonathon C. Taylor MEng, MSc, Michael B. Hanney BSc, MSc & Wendy B. Tindale MSc, PhD

  2. Medical Physics Group (Cardiovascular Science), University of Sheffield, Sheffield, United Kingdom

    Shelley Redgate BSc, MSc, David C. Barber BA, MSc, PhD & John W. Fenner BSc, PhD

  3. Cardiology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

    Abdallah Al-Mohammad MD, FRCP(Edin), FRCP(Lon), FESC

Authors
  1. Shelley Redgate BSc, MSc
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  2. David C. Barber BA, MSc, PhD
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  3. John W. Fenner BSc, PhD
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  4. Abdallah Al-Mohammad MD, FRCP(Edin), FRCP(Lon), FESC
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  5. Jonathon C. Taylor MEng, MSc
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  6. Michael B. Hanney BSc, MSc
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  7. Wendy B. Tindale MSc, PhD
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Corresponding author

Correspondence to Shelley Redgate BSc, MSc.

Additional information

See related editorial, doi:10.1007/s12350-015-0321-2.

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Redgate, S., Barber, D.C., Fenner, J.W. et al. A study to quantify the effect of patient motion and develop methods to detect and correct for motion during myocardial perfusion imaging on a CZT solid-state dedicated cardiac camera. J. Nucl. Cardiol. 23, 514–526 (2016). https://doi.org/10.1007/s12350-015-0314-1

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  • DOI: https://doi.org/10.1007/s12350-015-0314-1

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