Abstract
Background
Cardiovascular implantable electronic devices (CIED) infections are life-threatening complications. The diagnosis can be difficult to establish. Our purpose is to evaluate the diagnostic value of 18F-FDG PET.
Methods
Forty patients who received work-up for suspected CIED infection were retrospectively included (group 1) and compared with 40 controls (group 2); CIED patients were referred for oncologic PET. PET-CT data were blindly assessed. Interpretation was based on visual analysis of both attenuation-corrected and non-corrected images and a semi-quantitative analysis was performed. The gold standard was bacteriological data of explanted devices or clinical follow-up for at least 1 year.
Results
Infection was present in 18 out of 40 patients of group 1. Sensitivity, specificity, positive predictive value, and negative predictive value of PET-CT were 83%, 95%, 94%, and 88%, respectively. Accuracy was 90%. PET-CT revealed the presence of additional pathological hypermetabolic foci in 28% of cases. PET-CT was negative at implanted devices in all patients of group 2.
Conclusion
18F-FDG PET-CT is helpful in the work-up of suspected CIED infections. It is a potential tool to make the accurate diagnosis of CIED infection and to assess the extent of infection. The promising results in this indication need to be validated in a prospective multicenter study.
Similar content being viewed by others
References
Uslan DZ, Baddour LM. Cardiac device infections: Getting to the heart of the matter. Curr Opin Infect Dis 2006;19:345-8.
Glaudemans AW, de Vries EF, Galli F, Dierckx RA, Slart RH, Signore A. The use of (18)F-FDG-PET/CT for diagnosis and treatment monitoring of inflammatory and infectious diseases. Clin Dev Immunol 2013. doi:10.1155/2013/623036.
Haroon A, Zumla A, Bomanji J. Role of fluorine 18 fluorodeoxyglucose positron emission tomography-computed tomography in focal and generalized infectious and inflammatory disorders. Clin Infect Dis 2012;54:1333-41.
Bensimhon L, Lavergne T, Hugonnet F, Mainardi JL, Latremouille C, Maunoury C, et al. Whole body [(18) F]fluorodeoxyglucose positron emission tomography imaging for the diagnosis of pacemaker or implantable cardioverter defibrillator infection: A preliminary prospective study. Clin Microbiol Infect 2011;17:836-44.
Ploux S, Riviere A, Amraoui S, Whinnett Z, Barandon L, Lafitte S, et al. Positron emission tomography in patients with suspected pacing system infections may play a critical role in difficult cases. Heart Rhythm 2011;8:1478-81.
Sarrazin JF, Philippon F, Tessier M, Guimond J, Molin F, Champagne J, et al. Usefulness of fluorine-18 positron emission tomography/computed tomography for identification of cardiovascular implantable electronic device infections. J Am Coll Cardiol 2012;59:1616-25.
Cautela J, Alessandrini S, Cammilleri S, Giorgi R, Richet H, Casalta JP, et al. Diagnostic yield of FDG positron-emission tomography/computed tomography in patients with CEID infection: A pilot study. Europace 2013;15:252-7.
Voigt A, Shalaby A, Saba S. Continued rise in rates of cardiovascular implantable electronic device infections in the United States: Temporal trends and causative insights. Pacing Clin Electrophysiol 2010;33:414-9.
Brinker J. Imaging for infected cardiac implantable electronic devices: A new trick for your pet. J Am Coll Cardiol 2012;59:1626-8.
Leccisotti L, Perna F, Lago M, Leo M, Stefanelli A, Calcagni ML, et al. Cardiovascular implantable electronic device infection: Delayed vs standard FDG PET-CT imaging. J Nucl Cardiol 2014;42:623-8.
Erba PA, Sollini M, Conti U, Bandera F, Tascini C, De Tommasi SM, et al. Radiolabeled WBC scintigraphy in the diagnosic workup of patients with suspected device-related infections. J Am Coll Cardiol Cardiovasc Imaging 2013;6:1075-86.
Chen W, Kim J, Molchanova-Cook OP, Dilsizian V. The potential of FDG PET/CT for early diagnosis of cardiac device and prothetic valve infection before morphologic damages ensue. Curr Cardiol Rep 2014;16:459.
Israel O, Keidar Z. PET/CT imaging in infectious conditions. Ann N Y Acad Sci 2011;1228:150-66.
Bertagna F, Bisleri G, Motta F, Merli G, Cossalter E, Lucchini S, et al. Possible role of F18-FDG-PET/CT in the diagnosis of endocarditis: Preliminary evidence from a review of the literature. Int J Cardiovasc Imaging 2012;28:1417-25.
Millar BC, Prendergast BD, Alavi A, Moore JE. 18 FDG-positroon emission tomography (PET) has a role to play in the diagnosis and therapy of infective endocarditis and cardiac device infection. Int J Cardiol 2013;167:1724-36.
Harisankar CN, Mittal BR, Agrawal KL, Abrar ML, Bhattacharya A. Utility of high fat and low carbohydrate diet in suppressing myocardial FDG uptake. J Nucl Cardiol 2011;18:926-36.
Ahmed FZ, James J, Tout D, Arumugam P, Mamas M, Zaidi AM. Metal artefact reduction algorithms prevent false positive results when assessing patients for cardiac implantable electronic device infection. J Nucl Cardiol 2015;22:219-20.
Disclosures
None.
Author information
Authors and Affiliations
Corresponding author
Additional information
See related editorial, doi:10.1007/s12350-015-0102-y.
Rights and permissions
About this article
Cite this article
Tlili, G., Amroui, S., Mesguich, C. et al. High performances of 18F-fluorodeoxyglucose PET-CT in cardiac implantable device infections: A study of 40 patients. J. Nucl. Cardiol. 22, 787–798 (2015). https://doi.org/10.1007/s12350-015-0067-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12350-015-0067-x