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Prediction of all-cause mortality from gated-SPECT global myocardial wall thickening

Comparison with ejection fraction and global longitudinal 2D-strain

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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The aim of this study was to assess the correlation between global wall thickening (GWT) obtained by gated-single photon emission computed tomography (SPECT) and echocardiographic measures [ejection fraction (EF), global longitudinal strain (GLS), and strain rate (GLSR)] and to compare their prognostic value for all-cause mortality.

Methods and Results

Seventy-four patients with referral for dipyridamole myocardial perfusion SPECT were prospectively included and underwent transthoracic echocardiography to measure left ventricular EF, GLS, and GLSR. The strongest correlation with GWT was for EF (R = 0.63, P < .001), followed by GLSR (R = −0.57, P < .001) and GLS (R = −0.53, P < .001). There were ten deaths over a period of 14.6 ± 5.7 months. Using the multivariate Cox analysis, summed stress score (HR 1.108; P = .023), EF (HR 1.01, P = .031), GLS (HR 1.593, P = .001), and GWT (HR 0.898, P = .034) remained independent predictors of mortality. Mean survival rate evaluated by Kaplan-Meier analysis was longer in patients with GWT ≥ 24% (21.9 ± 0.6 months) than those with GWT < 24% (13.6 ± 2.7 months; P < .001).

Conclusions

GWT assessed is a highly sensitive tool to detect early myocardial systolic dysfunction and may bring additional prognostic information.

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Acknowledgments

Authors thank Bernard Estivals and the staff of the department of nuclear medicine of Rangueil for their technical support.

Disclosure

Doctor Lairez has received research support (equipment and software) from Kontron for studies of 2D strain. However, the current study was not supported by those grants.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Toulouse University Hospital, 1, Avenue Jean Poulhès, TSA 50032, 31059, Toulouse Cedex 9, France

    Olivier Lairez MD, PhD, Thomas Cognet MD, Laurent Dercle MD, Simon Méjean MD, Delphine Bastié MD, Rainui Richaud MD, Audrey Fouilloux MD & Isabelle Berry MD, PhD

  2. Department of Cardiology, University Hospital of Rangueil, Toulouse, France

    Olivier Lairez MD, PhD, Thomas Cognet MD, Simon Méjean MD, Matthieu Berry MD, Matthieu Gautier MD, Audrey Fouilloux MD, Michel Galinier MD, PhD, Didier Carrié MD, PhD & Pierre Massabuau MD

  3. Cardiac Imaging Center, Toulouse University Hospital, Toulouse, France

    Olivier Lairez MD, PhD, Thomas Cognet MD, Laurent Dercle MD, Simon Méjean MD, Matthieu Berry MD, Delphine Bastié MD, Rainui Richaud MD, Matthieu Gautier MD, Audrey Fouilloux MD, Michel Galinier MD, PhD, Didier Carrié MD, PhD, Pierre Massabuau MD & Isabelle Berry MD, PhD

  4. Medical School of Rangueil, University Paul Sabatier, Toulouse, France

    Olivier Lairez MD, PhD, Matthieu Berry MD, Michel Galinier MD, PhD & Isabelle Berry MD, PhD

  5. Medical School of Purpan, University Paul Sabatier, Toulouse, France

    Didier Carrié MD, PhD

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  1. Olivier Lairez MD, PhD
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  2. Thomas Cognet MD
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  3. Laurent Dercle MD
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Correspondence to Olivier Lairez MD, PhD.

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Lairez, O., Cognet, T., Dercle, L. et al. Prediction of all-cause mortality from gated-SPECT global myocardial wall thickening. J. Nucl. Cardiol. 21, 86–95 (2014). https://doi.org/10.1007/s12350-013-9813-0

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  • DOI: https://doi.org/10.1007/s12350-013-9813-0

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