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The prevalence and predictive accuracy of quantitatively defined transient ischemic dilation of the left ventricle on otherwise normal SPECT myocardial perfusion imaging studies

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Aim

TID in the setting of otherwise normal MPI has been suggested as a marker of high risk CAD. In this study we estimate the variance of TID in a normal population and the statistical frequency of false positive TID. This will provide an indirect measurement of predictive accuracy (PA) in a mixed referral population.

Objective

To study the PA of TID in otherwise normal MPI.

Methods

688 consecutive patients were studied. We defined TID according to the standard method at 2 cut-off values; 1SD and 2SD, and also by a BSA normalized volume difference with gender-specific 2SD limits (NrVD).

Results

457 patients with otherwise normal MPI were analyzed. PA of TID at 1SD was 4% and 26% at 2SD. PA was slightly higher (42%) using the NrVD, however, still too low to be clinically useful as a high-risk marker. PA of TID in patients with perfusion abnormalities was 58% at 1SD, 80% at 2SD and slightly higher (93%) by NrVD.

Conclusions

In the setting of otherwise normal MPI, elevated TIDr has a low prevalence and poor predictive accuracy and should not be considered summarily as a marker of high risk CAD.

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Conflict of interest

The authors have indicated that they have no financial conflicts of interest.

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Authors and Affiliations

  1. Cardiology Department, Al-Azhar School of Medicine, Cairo, Egypt

    Mohamed A. Mandour Ali MSc & Adel H. Allam MD

  2. Nuclear Cardiology Laboratory, Cardiovascular Division and the Cardiovascular Imaging Center, Department of Internal Medicine, University of Virginia Health System, Box PO Box 800170, 1215 Lee Street, Charlottesville, VA, 22908, USA

    Mohamed A. Mandour Ali MSc, Jamieson M. Bourque MD, George A. Beller MD & Denny D. Watson PhD

Authors
  1. Mohamed A. Mandour Ali MSc
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  2. Jamieson M. Bourque MD
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  3. Adel H. Allam MD
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  4. George A. Beller MD
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  5. Denny D. Watson PhD
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Corresponding author

Correspondence to Denny D. Watson PhD.

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Mandour Ali, M.A., Bourque, J.M., Allam, A.H. et al. The prevalence and predictive accuracy of quantitatively defined transient ischemic dilation of the left ventricle on otherwise normal SPECT myocardial perfusion imaging studies. J. Nucl. Cardiol. 18, 1036–1043 (2011). https://doi.org/10.1007/s12350-011-9458-9

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  • DOI: https://doi.org/10.1007/s12350-011-9458-9

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