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The technetium shortage

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References

  1. Committee on Medical Isotope Production Without Highly Enriched Uranium, National Research Council, National Academy of Sciences. Medical isotope production without highly enriched uranium. Washington, DC: National Academies Press. 2009. Available at http://www.nap.edu/catalog/12569.html.

  2. Einstein AJ. Breaking America’s dependence on imported molybdenum. JACC Cardiovasc Imaging 2009;2:369-71.

    Article  PubMed  Google Scholar 

  3. www.nrucanada.ca/en/home/projectrestart/statusupdates/nrustatusupdate64.aspx. Accessed 10 July 2010.

  4. Maddahi J, Mendez R, Mahmarian JJ, Thomas G, Babla H, Bai C, et al. Prospective multicenter evaluation of rapid, gated SPECT myocardial perfusion upright imaging. J Nucl Cardiol 2009;16:351-7.

    Article  PubMed  Google Scholar 

  5. Borges-Neto S, Pagnanelli RA, Shaw LK, Honeycutt E, Shwartz SC, Adams GL, et al. Clinical results of a novel wide beam reconstruction method for shortening scan time of Tc-99m cardiac SPECT perfusion studies. J Nucl Cardiol 2007;14:555-65.

    Article  PubMed  Google Scholar 

  6. DePuey EG, Gadiraju R, Clark J, Thompson L, Anstett F, Shwartz SC. Ordered subset maximization and wide beam reconstruction “half-time” gated myocardial perfusion SPECT functional imaging: A comparison to “full-time” filtered backprojection. J Nucl Cardiol 2008;15:547-63.

    Article  PubMed  Google Scholar 

  7. Holly TA, Abbott BG, Al-Mallah M, Calnon DC, Cohen MC, DiFilippo FP, et al. ASNC imaging guidelines for nuclear cardiology procedures: Single photon-emission computed tomography. J Nucl Cardiol 2010. www.asnc.org/imageuploads/ImagingGuidelineSPECTJune2010.pdf.

  8. Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol 2009;16:255-76.

    Article  PubMed  Google Scholar 

  9. Babla H, Bai C, Conwell R. A triple-head solid state camera for cardiac single photon emission tomography (SPECT). In: Franks LA, Burger A, James RB, Barber HB, Doty FP, Roehrig H, editors. Proc SPIE 2005;6319:63190M.

  10. www.CardiArc.com. Accessed 30 May 2008.

  11. Sharir T, Ben-Haim S, Merzon K, et al. High-speed myocardial perfusion imaging Initial clinical comparison with conventional dual detector anger camera imaging. J Am Coll Cardiol Cardiovasc Imaging 2008;1:156-63.

    Google Scholar 

  12. Yalamanchili P, Wexler E, Hayes M, Yu MMD, Bozek J, Radeke H, et al. Mechanism of uptake and retention of 18F BMS747158-02 in cardiomyocytes: A novel PET myocardial imaging agent. J Nucl Cardiol 2007;14:782-8.

    Article  PubMed  Google Scholar 

  13. Yu M, Guaraldi MT, Mistry M, Kagan M, McDonald JL, Drew K, et al. BMS747158-02: A novel PET myocardial perfusion imaging agent. J Nucl Cardiol 2007;14:789-98.

    Article  CAS  PubMed  Google Scholar 

  14. Huisman M, Higuchi T, Reder S, Nekolla S, Poethko T, Wester HJ, et al. Initial characterization of an 18F-labeled myocardial perfusion tracer. J Nucl Med 2008;49:630-6.

    Article  PubMed  Google Scholar 

  15. Nekolla SG, Reder S, Higuchi T, Saraste A, Dzewas G, Preissl A, et al. Evaluation of the novel myocardial perfusion PET tracer 18F-BMS747158-02: Comparison to 13N ammonia and validation with microspheres in a pig model. Circulation 2009.

  16. Maddahi J, Schiepers C, Czernin J, Huang H, Schelbert H, Wijatyk A, et al. First human study of BMS747158, a novel F-18 labeled tracer for myocardial perfusion imaging. J Nucl Med. 2008;49:70P.

    Google Scholar 

  17. Maddahi J, Huang H, Czernin J, Schelbert H, Bengel F, Schiepers C, et al. Phase 1 human safety, dosimetry, biodistribution, and rest/stress myocardial imaging characteristics of F-18 labeled BMS747158. J Am Coll Cardiol. 2009;53A:297P.

    Google Scholar 

  18. Case JA, Maddahi J, Bengel FM, Bateman T, Dahlbom M, Lazewatsky J. Imaging properties of F-18 labeled myocardial perfusion PET agent, BMS747158: Dosage, acquisition time and scanner type. J Nucl Med. 2009;50:109P.

    Google Scholar 

  19. Maddahi J, Huang S, Schiepers C, Bengel F, Czernin J, Schelbert H, et al. Same day rest-stress protocols for PET imaging with the new F-18 labeled BMS747158 myocardial perfusion tracer. J Nucl Med. 2009;50:219P.

    Google Scholar 

  20. Maddahi J, Czernin J, Ehlgen A, Lazewatsky J, Xu Q, Phelps ME. Comparison of F-18 labeled BMS747158 PET and Tc-99m labeled SPECT myocardial perfusion imaging for detection and evaluation of coronary artery disease. J Am Coll Cardiol 2010;55:A65.

    Google Scholar 

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Acknowledgment

The authors appreciate the generous assistance provided by experts in the international medical isotope supply chain, particularly that provided by Ira N Goldman, MA and William C Dawes, Jr of Lantheus Medical Imaging.

Conflict of interest

Duality of interests: G. S. Thomas serves as a consultant for Astellas Pharma and Lantheus Medical Imaging and has served as a consultant for GE Healthcare. He receives research grants from Astellas and PGxHealth. He serves on the speaking bureau of Astellas Pharma. J. Maddahi serves as a consultant for and has received research grants from Lantheus Medical Imaging and Digirad Corporation. He is on the speaking bureau of Lantheus Medical Imaging and Astellas Pharma.

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Authors and Affiliations

  1. Division of Cardiology, University of California, Irvine, CA, USA

    Gregory S. Thomas MD, MPH, FACC, FASNC

  2. Mission Internal Medical Group, Mission Viejo, CA, USA

    Gregory S. Thomas MD, MPH, FACC, FASNC

  3. Department of Molecular and Medical Pharmacology (Nuclear Medicine), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Jamshid Maddahi MD, FACC

  4. Department of Medicine (Cardiology), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Jamshid Maddahi MD, FACC

Authors
  1. Gregory S. Thomas MD, MPH, FACC, FASNC
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  2. Jamshid Maddahi MD, FACC
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Corresponding author

Correspondence to Gregory S. Thomas MD, MPH, FACC, FASNC.

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Thomas, G.S., Maddahi, J. The technetium shortage. J. Nucl. Cardiol. 17, 993–998 (2010). https://doi.org/10.1007/s12350-010-9281-8

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