References
Miyamoto MI, Vernotico SL, Majmundar M, Thomas GS. Pharmacologic stress myocardial perfusion imaging: A practice approach. J Nuc Cardiol 2007;14:250-5
Cerqueira MD, Verani MS, Schwaiger M, Heo J, Iskandrian AS. Safety profile of adenosine stress perfusion imaging: Results of the Adenoscan Multicenter Trial Registry. JACC 1994;23(2):384-9
Iskandrian AE, Bateman TM, Belardinelli L, Blackburn B, Cerqueira MD, Hendel RC, et al. Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: Results of the ADVANCE phase 3 multicenter international trial. J Nuc Cardiol 2007;14:645-58
Cerqueira MD, Nguyen P, Staehr P, Underwood SR, Iskandrian AE. Effects of age, gender, obesity and diabetes on the efficacy and safety of the selective A2A agonist, regadenoson versus adenosine in myocardial perfusion imaging: Integrated ADVANCE-MPI trial results. JACC Imaging 2008;1:307-16
Mahmarian JJ, Cerqueira MD, Iskandrian AE, Bateman TM, Thomas GS, Hendel RC, et al. Regadenoson induces comparable left ventricular perfusion defects as adenosine: A quantitative analysis from the advance MPI 2 trial. JACC Imaging 2009;2:959-68
www.lexascan.com/home.php. Accessed February 24, 2010
Mekkaoui C, Jadbabaie F, Dione DP, Meoli DF, Purushothaman K, Belardinelli L, et al. Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-SestaMIBI biodistribution and kinetics. JACC Imaging 2009;2:1198-208
Lieu HD, Shryock JC, von Mering GO, Gordi T, Blackburn B, Olmsted AW, et al. Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans. J Nuc Cardiol 2007;14:514-20
Zhao G, Messina E, Xu X, Ochoa M, Sun HL, Leung K, et al. Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson (CVT-3146), a novel adenosine A2A receptor agonist. J Cardiovasc Pharmacol 2007;49(6):369-75
Gaemperli O, Schepis T, Koepfli P, Siegrist PT, Fleischman S, Nguyen P, et al. Interaction of caffeine with regadenoson-induced hyperemic myocardial blood flow as measured by positron emission tomography a randomized, double-blind, placebo-controlled crossover trial. J Am Coll Cardiol 2008;51:328-9
Samady H, Wackers FJ, Joska TM, Zaret BL, Jain D. Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise. J Nuc Card 2002;9(2):188-96
Holly TA, Satran A, Bromet DS, Mieres JH, Frey MJ, Elliott MD, et al. The impact of adjunctive adenosine infusion during exercise myocardial perfusion imaging: Results of the Both Exercise and Adenosine Stress Test (BEAST) trial. J Nuc Card 2003;10(3):291-6
Thomas GS, Thompson RC, Miyamoto MI, Ip TK, Rice DL, Milikien D, et al. The RegEx trial: A randomized, double-blind, placebo- and active- controlled pilot study combining regadenoson, a selective A2A adenosine agonist, with low-level exercise, in patients undergoing myocardial perfusion imaging. J Nuc Card 2009;16(1):63-72
Leaker BR, O’Connor B, Hansel TT, Barnes PJ, Meng L, Mathur VS, et al. Safety of regadenoson, and adenosine A2A agonist for myocardial perfusion imaging, in mild asthma patients: A randomized, double-blind, placebo-controlled trial. J Nuc Card 2008;15(3):329-36
Thomas GS, Tammelin BR, Schiffman GL. Safety of regadenoson, a selective A2A agonist, in patients with chronic obstructive pulmonary disease: A randomized, double-blind, placebo-controlled trial. J Nuc Card 2008;15(3):319-28
Gordi T, Blackburn B, Lieu H. Regadenoson pharmacokinetics and tolerability in subjects with impaired renal function. J Clin Pharmacol 2007;47:825-33
Laighold S, Druz R. Initial clinical experience with a selective A2A receptor agonist, regadenoson, in a patient with end-stage renal disease on hemodialysis. J Nuc Card 2009;16:478-80
Al Jaroudi W, Hermann D, Hage F. Safety of Regadenoson in patients with End-Stage Renal Disease. Am J Cardiol 2010;105:133-5
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Gemignani, A.S., Abbott, B.G. The emerging role of the selective A2A agonist in pharmacologic stress testing. J. Nucl. Cardiol. 17, 494–497 (2010). https://doi.org/10.1007/s12350-010-9211-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12350-010-9211-9