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Late recurrence of gastric carcinoma 15 years after surgery

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Abstract

A 70-year-old man who had undergone total gastrectomy 15 years ago for mucinous gastric carcinoma on the lesser curvature of the cardia, visited our hospital complaining of cough. Chest X-ray showed a right hilar shadow and an infiltrative shadow in the left middle lung field, which was not seen in the previous year. Whole-body positron emission tomography-computed tomography (CT) revealed abnormal uptake in the irregular consolidation of the left lung, enlarged right hilar lymph nodes, and a mass lesion on the right adrenal gland. Advanced primary lung adenocarcinoma with multi-organ metastasis was suspected and a CT-guided percutaneous lung biopsy was performed. Histopathological examination showed immunostaining patterns in complete accordance with those of the resected specimen of stomach, and the diagnosis of late recurrence of gastric carcinoma was confirmed. Pulmonary metastasis might have occurred as a direct hematogenous metastasis rather than through the liver. He achieved 31 months survival after the diagnosis receiving some sequences of chemotherapy. Late recurrence over 10 years after gastrectomy is extremely rare and significant predictive factors of late recurrence are not known. We hope that this case will help in detecting significant factors predictive of late recurrence after gastrectomy for gastric carcinoma.

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References

  1. Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.

    Article  Google Scholar 

  2. Lee JW, Ali B, Yoo HM, et al. Conditional survival analysis in Korean patients with gastric cancer undergoing curative gastrectomy. BMC Cancer. 2015;15:1005.

    Article  Google Scholar 

  3. Park JH, Ryu MH, Kim HJ, et al. Risk factors for selection of patients at high risk of recurrence or death after complete surgical resection in stage I gastric cancer. Gastric Cancer. 2016;19:226–33.

    Article  CAS  Google Scholar 

  4. Kim CD, Chang MC, Roh HC, et al. Factors influencing recurrence after curative resection for advanced gastric cancer. J Korean Surg Soc. 2003;65:301–8.

    Google Scholar 

  5. Moon YW, Jeung HC, Rha SY, et al. Changing patterns of prognosticators during 15-year follow-up of advanced gastric cancer after radical gastrectomy and adjuvant chemotherapy: a 15-year follow-up study at a single korean institute. Ann Surg Oncol. 2007;14:2730–7.

    Article  Google Scholar 

  6. Lee JH, Kim HI, Kim MG, et al. Recurrence of gastric cancer in patients who are disease-free for more than 5 years after primary resection. Surgery. 2016;159:1090–8.

    Article  Google Scholar 

  7. Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 2011;14:101–12.

    Article  Google Scholar 

  8. Yatabe Y, Mitsudomi T, Takahashi T. TTF-1 expression in pulmonary adenocarcinomas. Am J Surg Pathol. 2002;26:767–73.

    Article  Google Scholar 

  9. Hirano T, Auer G, Maeda M, et al. Human tissue distribution of TA02, which is homologous with a new type of aspartic proteinase, napsin A. Jpn J Cancer Res. 2000;91:1015–21.

    Article  CAS  Google Scholar 

  10. Cowan ML, Li QK, Illei PB. CDX-2 expression in primary lung adenocarcinoma. Appl Immunohistochem Mol Morphol. 2016;24:16–9.

    Article  CAS  Google Scholar 

  11. Kummar S, Fogarasi M, Canova A, et al. Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br J Cancer. 2002;86:1884–7.

    Article  CAS  Google Scholar 

  12. Bayrak R, Haltas H, Yenidunya S. The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: cytokeratin 7−/20+ phenotype is more specific than CDX2 antibody. Diagn Pathol. 2012;7:9.

    Article  Google Scholar 

  13. Yasuda T, Hayashi S, Nakahata Y, et al. Recurrence of cutaneous and lymph node metastases 12 years after radical total gastrectomy for stage IIA gastric cancer: a case report. Intern Med. 2020;59:1387–93.

    Article  Google Scholar 

  14. Harada M, Tsujimoto H, Ichikura T, et al. A case of a long-term survival achieved by surgical treatment and chemotherapy for late recurrence of AFP-producing gastric cancer. Surg Case Rep. 2019;5:106.

    Article  Google Scholar 

  15. Watanabe M, Hasegawa K, Kanamori A, et al. Late recurrence of gastric cancer in the ovary and uterine cervix. Int Cancer Conf J. 2016;5:206–13.

    Article  Google Scholar 

  16. Yamamoto T, Mori T, Matsushima H, et al. Late, isolated metastasis from poorly differentiated gastric cancer to the uterine cervix. Gynecol Oncol Case Rep. 2014;8:17–20.

    Article  Google Scholar 

  17. Blanchette P, Lipton JH, Barth D, et al. Case report of very late gastric cancer recurrence. Curr Oncol. 2013;20:e161–e164164.

    Article  CAS  Google Scholar 

  18. Fukushima M, Katayama Y, Shigemori Y, et al. Clivus metastasis from gastric signet ring cell carcinoma after a 10-year disease-free interval—case report. Neurol Med Chir. 2012;52:751–3.

    Article  Google Scholar 

  19. Okugawa Y, Toiyama Y, Inoue Y, et al. Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection. World J Surg Oncol. 2010;8:104.

    Article  Google Scholar 

  20. Aihara R, Mochiki E, Ohotake S, et al. Peritoneal recurrence of gastric cancer with mucin phenotype 12 years after curative resection: report of a case. Surg Today. 2007;37:325–9.

    Article  Google Scholar 

  21. Blows FM, Driver KE, Schmidt MK, et al. Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies. PLoS Med. 2010;7:e1000279.

    Article  Google Scholar 

  22. Banys-Paluchowski M, Reinhardt F, Fehm T. Disseminated tumor cells and dormancy in breast cancer progression. Adv Exp Med Biol. 2020;1220:35–433.

    Article  Google Scholar 

  23. Kang Y, Pantel K. Tumor cell dissemination: emerging biological insights from animal models and cancer patients. Cancer Cell. 2013;23:573–81.

    Article  CAS  Google Scholar 

  24. Giancotti FG. Mechanisms governing metastatic dormancy and reactivation. Cell. 2013;155:750–64.

    Article  CAS  Google Scholar 

  25. Schewe DM, Aguirre-Ghiso JA. ATF6alpha-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci USA. 2008;105:10519–24.

    Article  CAS  Google Scholar 

  26. White DE, Kurpios NA, Zuo D, et al. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell. 2004;6:159–70.

    Article  CAS  Google Scholar 

  27. Zhang J, Zhou Y, Tang PMK, et al. Mechanotransduction and cytoskeleton remodeling shaping YAP1 in gastric tumorigenesis. Int J Mol Sci. 2019;20:E1576.

    Article  Google Scholar 

  28. Zang D, Zhang C, Li C, et al. LPPR4 promotes peritoneal metastasis via Sp1/integrin α/FAK signaling in gastric cancer. Am J Cancer Res. 2020;10:1026–44.

    Google Scholar 

  29. Kawano A, Nakajima TE, Oda I, et al. Comparison of advanced adenocarcinomas of esophagogastric junction and distal stomach in Japanese patients. Gastric Cancer. 2014;17:54–60.

    Article  CAS  Google Scholar 

  30. Tanai C, Hamaguchi T, Watanabe S, et al. A case of long-term survival after surgical resection of solitary pulmonary metastasis from gastric cancer. Jpn J Clin Oncol. 2010;40:85–9.

    Article  Google Scholar 

Download references

Acknowledgements

The authors wish to thank the following individuals for assistance in submitting this article: Dr Naoko Inoshita at Department of Pathology, Toranomon Hospital, Tokyo, Japan.

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Authors and Affiliations

  1. Department of Gastrointestinal Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-0001, Japan

    Nobuhiko Ogasawara, Yu Ohkura, Masaki Ueno, Shusuke Haruta, Takatsugu Fujii, Aya Honda, Tsuyoshi Tanaka & Harushi Udagawa

  2. Department of Pathology, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-0001, Japan

    Atsuhito Nakayama

Authors
  1. Nobuhiko Ogasawara
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  2. Yu Ohkura
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  3. Masaki Ueno
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  4. Shusuke Haruta
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  5. Atsuhito Nakayama
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  6. Takatsugu Fujii
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  7. Aya Honda
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  8. Tsuyoshi Tanaka
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  9. Harushi Udagawa
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Correspondence to Yu Ohkura.

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Nobuhiko Ogasawara, Yu Ohkura, Masaki Ueno, Shusuke Haruta, Atsuhito Nakayama, Takatsugu Fujii, Aya Honda, Tsuyoshi Tanaka, Harushi Udagawa declare that they have no conflict of interest.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Ogasawara, N., Ohkura, Y., Ueno, M. et al. Late recurrence of gastric carcinoma 15 years after surgery. Clin J Gastroenterol 13, 746–753 (2020). https://doi.org/10.1007/s12328-020-01143-2

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  • DOI: https://doi.org/10.1007/s12328-020-01143-2

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