Skip to main content

Advertisement

SpringerLink
Log in

A rectal neuroendocrine tumor in a patient with Crohn’s disease: a case report and literature review

  • Case Report
  • Published:
Clinical Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

Crohn’s disease is recognized to increase the risk of gastrointestinal malignances. Adenocarcinoma is the most common malignancy in these patients. Association between Crohn’s disease and adenocarcinoma in the small intestine has already been established, however, the association between neuroendocrine tumor and Crohn’s disease remains uncertain. We report a 39-year-old man with Crohn’s disease, who was diagnosed with NET in the rectum. He had suffered from fever and anal pain due to the anal fistula and abscess. The disease state was considered to be resistant to medical treatment. He underwent total proctocolectomy, small bowel resection, anal fistula drainage with ileostomy. Postoperative histology revealed a neuroendocrine tumor in the rectum. His postoperative course was uneventful, and he followed a good course under treatment with infliximab and mercaptopurine hydrate. This case highlights the need of careful observation of resected specimens in light of the possibility of NET, especially those with anal disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Savoca PE, Ballantyne GA, Cahow CE. Gastrointestinal malignancies in Crohn’s disease, a 20 year experience. Dis Colon Rectum. 1990;33:7–11.

    Article  CAS  PubMed  Google Scholar 

  2. Owzarek D, Cibor D, Szczepanski W, et al. Concomitant carcinoid tumor and papillary urothelial neoplasm of low malignant potential in a patient with Crohn’s disease: a case report. Eur J Gastroenterol Hepatol. 2008;20(12):1231–4.

    Article  Google Scholar 

  3. Stout AP. Carcinoid tumors of the rectum derived from Erspamer’s pre-enterochrome cells. Am J Pathol. 1942;18:993–1009.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Villote J, Mouchet A, Martin E, et al. Crohn’s disease revealed by a vesico-intestinal fistula and associated with a carcinoid tumor of the small intestine. Sem Hop Paris. 1969;45:1620–5.

    Google Scholar 

  5. Wood WJ, Archer R, Schaefner JW, et al. Coexistence of regional enteritis and carcinoid tumor. Gastroenterology. 1970;59:265–9.

    Article  CAS  PubMed  Google Scholar 

  6. Tehrani MA, Carface DC. Carcinoid tumor and Crohn’s disease. Br J Clin Prac. 1975;29:123–4.

    CAS  Google Scholar 

  7. Feldman CH, Stavorovsky MM, Schuman E, et al. Regional enteritis, thymoma and multiple carcinoids: an unusual association. Int Surg. 1980;65:63–5.

    Google Scholar 

  8. Janin Y, Schwartz D, Becker JM, et al. Crohn’s disease and carcinoid tumor of the appendix in a child. Z Kinderchir. 1981;4:376–69.

    Google Scholar 

  9. Van Lindingham SB, Kluppel S, Symmonds R, et al. Coexistence carcinoid tumor and Crohn’s disease. J Surr Oncol. 1983;24:310–4.

    Article  Google Scholar 

  10. Brown GA, Kollin J, Rajan RK. The coexistence of carcinoid tumor and Crohn’s disease. J Clin Gastroenterol. 1986;8:286–9.

    Article  CAS  PubMed  Google Scholar 

  11. Kosakowski C, Thompson JE, Feinberg MJ. Coexistence of primary Crohn’s disease and carcinoid tumor isolated to the appendix. Acta Chir Scand. 1986;152:233–6.

    CAS  PubMed  Google Scholar 

  12. Bauer T. Karcinoid og mb. Crohn i appendix. Ugeskr Laeger. 1986;148:1091–2.

    CAS  PubMed  Google Scholar 

  13. Kvist O, Jacobsen N. Malignancy in Crohn’s disease. Scand J Gastroenterol. 1986;21:82–6.

    Article  CAS  PubMed  Google Scholar 

  14. Kortbeek J, Kelly JK. Carcinoid tumor and inflammatory bowel disease. J Surg Oncol. 1992;49:122–6.

    Article  CAS  PubMed  Google Scholar 

  15. Hock YL, Scott KW, Grace RH. Mixed adenocarcinoma/carcinoid tumour of large bowel in a patient with Crohn’s disease. J Clin Pathol. 1993;24:310–4.

    Google Scholar 

  16. LeMarc’hadour F, Bost F, Peoc’h M, et al. Carcinoid tumor complicating of the literature. Pathol Res Pract. 1994;190:1185–92.

    Article  Google Scholar 

  17. Greenstein AJ, Balasubramanian S, Harpaz N, et al. Carcinoid tumor and inflammatory bowel disease: a study of eleven cases and review of the literature. Am J Gastroenterol. 1997;92(4):682–5.

    CAS  PubMed  Google Scholar 

  18. Hamaguti Y, Obi Y, Wada J, et al. Two cases of inflammatory bowel diseases associated with gastrointestinal carcinoids. Jpn J Gastroenterogical Surg. 1997;30(10):2039–43.

    Article  Google Scholar 

  19. Auber F, Gambiez L, Desreumaux P, et al. Mixed adenocarcinoid tumor and Crohn’s disease. J Clin Gastroenterol. 1998;26:353–4.

    Article  CAS  PubMed  Google Scholar 

  20. Cioffi U, De Simone M, Ferrero S, et al. Synchronous adenocarcinoma and carcinoid tumor of the terminal ileum in a Crohn’s disease patient. BMC. 2005;5:157.

    Google Scholar 

  21. Hazzan D, Eckstein JG, Steinhagen R. Carcinoid tumor and Crohn’s ileitis. Isr Med Assoc J. 2005;7:264.

    Google Scholar 

  22. Hwang H, Doyle J, Chai B, et al. Incidental malignant carcinoid within Crohn ileitis. Can J Surg. 2009;52(3):E58–59.

    PubMed  PubMed Central  Google Scholar 

  23. Boltin D, Levi Z, Halpern M, et al. Concurrent small bowel adenocarcinoma and carcinoid tumor in Chrohn’s disease-Case report and literature review. J Crohns Colitis. 2011;5:461–4.

    Article  PubMed  Google Scholar 

  24. Praticò C, Rizzelo F, Fornarini GS, et al. Four cases of carcinoid tumor in Crohn’s disease: coincidence or correlation? Int J Colorectal Dis. 2013;28:1743–5.

    Article  PubMed  Google Scholar 

  25. Mogollon M, Conde R, Segura I. Ileal carcinoid tumor within Crohn’s disease. Rev Esp Enferm Dig. 2014;106:298–9.

    CAS  PubMed  Google Scholar 

  26. Pellino G, Marcellinaro R, Candilio G, et al. The experience of a referral centre and literature overview of GIST and carcinoid tumours in inflammatory bowel diseases. Int J Surg. 2016;28:S133–S141141.

    Article  PubMed  Google Scholar 

  27. Dörfell Y, Swiidsinski A, Loening-Baucke V, et al. Common biostructure of the colonic microbiota in neuroendocrine tumors and Crohn’s disease and effect of therapy. Inflamm Bowel Dis. 2012;18:1663–711.

    Article  Google Scholar 

  28. Chen CC, Neugut AI, Rotterdam H. Risk factors for adenocarcinomas and malignant carcinoids of the small intestine: preliminary findings. Cancer Epidemiol Biomark Prev. 1994;3(3):205–7.

    CAS  Google Scholar 

  29. Wong M, Larson BK, Dhall D. neuroendocrine proliferations in inflammatory bowel disease: differentiating neuroendocrine tumor from neuroendocrine cell micronests. Histopathology. 2018. https://doi.org/10.1111/his.13769.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Second Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Japan

    Katsunori Suzuki, Masayoshi Yamamoto, Yuhi Suzuki, Takafumi Kawamura, Megumu Kamishima, Mayu Sakata, Kiyotaka Kurachi & Hiroya Takeuchi

  2. Department of Surgery, Hamamatsu Medical Center, 328 Tomitsukacho, Naka-ku, Hamamatsu, Japan

    Takashi Harada

  3. First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Japan

    Takuma Kagami, Shinya Tani, Mihoko Yamade, Yasushi Hamaya & Ken Sugimoto

  4. Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Japan

    Satoshi Osawa

Authors
  1. Katsunori Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masayoshi Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuhi Suzuki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Takafumi Kawamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Megumu Kamishima
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mayu Sakata
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takashi Harada
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Takuma Kagami
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Shinya Tani
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Mihoko Yamade
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Yasushi Hamaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Satoshi Osawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Ken Sugimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Kiyotaka Kurachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Hiroya Takeuchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masayoshi Yamamoto.

Ethics declarations

Conflict of interest

Katsunori Suzuki, Masayoshi Yamamoto, Yuhi Suzuki, Takafumi Kawamura, Megumu Kamishima, Mayu Sakata, Takashi Harada, Takuma Kagami, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Satoshi Osawa, Ken Sugimoto, Kiyotaka Kurachi and Hiroya Takeuchi declare that they have no conflict of interest.

Human/animal rights

This study does not include any data about human subjects.

Informed consent

This study does not involve human subjects and does not apply to giving informed consent.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Suzuki, K., Yamamoto, M., Suzuki, Y. et al. A rectal neuroendocrine tumor in a patient with Crohn’s disease: a case report and literature review. Clin J Gastroenterol 13, 320–327 (2020). https://doi.org/10.1007/s12328-019-01063-w

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12328-019-01063-w

Keywords

Search

Navigation