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A patient with esophageal cancer with bone metastasis who achieved pain relief with repetitive administration of strontium-89 chloride

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Abstract

A 75-year-old woman was diagnosed with esophageal cancer with difficulty in swallowing. She had a past history of rheumatoid arthritis, scleroderma, interstitial pneumonia, angina pectoris (with coronary artery bypass surgery) and arrhythmia (with pacemaker implantation). She refused surgery, and chemotherapy and radiotherapy were not performed because of the high risk accompanied with multiple comorbidities. She received proton therapy at another hospital and the primary lesion shrank. Bone metastasis in the thoracic vertebrae was diagnosed 10 months after diagnosis of esophageal cancer. Non-steroidal anti-inflammatory drugs and zoledronic acid were administered for back pain. Oxycodone was also administered but discontinued due to nausea. After strontium-89 (89Sr) chloride administration, her back pain was relieved. 89Sr was administered five times every 3 months, and the pain did not worsen until her death due to pneumonia 2 years after diagnosis of esophageal cancer. 89Sr was effective for pain from bone metastasis of esophageal cancer, and its repeated administration was safe.

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Disclosures

Conflict of Interest:

Osamu Maeda, Takafumi Ando, Kazuhiro Ishiguro, Osamu Watanabe, Ryoji Miyahara, Masanao Nakamura, Kohei Funasaka, Kazuhiro Furukawa, Yuichi Ando, and Katsuhiko Kato declare that they have no conflict of interest. Hidemi Goto received research grants from Chugai Pharmaceutical Co., Ltd., MSD K.K., Ajinomoto Pharhaceuticals Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Mitsubishi Tanabe Pharma Corporation., Bristol-Myers Squibb, Bayer Yakuhin Ltd, Daiichi Sankyo Company, Limited, AstraZeneca K.K., Dainippon Sumitomo Pharma Co., Ltd., Takeda Pharmaceutical Company Limited, and Eisai Co., Ltd.

Human/Animal Rights:

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent:

Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan

    Osamu Maeda & Yuichi Ando

  2. Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Takafumi Ando, Kazuhiro Ishiguro, Osamu Watanabe, Ryoji Miyahara, Masanao Nakamura, Kohei Funasaka, Kazuhiro Furukawa & Hidemi Goto

  3. Department of Radiological and Medical Laboratory Sciences, Nagoya University School of Health Sciences, 1-20, Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan

    Katsuhiko Kato

Authors
  1. Osamu Maeda
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  2. Takafumi Ando
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  3. Kazuhiro Ishiguro
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  4. Osamu Watanabe
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  5. Ryoji Miyahara
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  6. Masanao Nakamura
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  7. Kohei Funasaka
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  8. Kazuhiro Furukawa
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  9. Yuichi Ando
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  10. Katsuhiko Kato
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  11. Hidemi Goto
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Corresponding author

Correspondence to Osamu Maeda.

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Maeda, O., Ando, T., Ishiguro, K. et al. A patient with esophageal cancer with bone metastasis who achieved pain relief with repetitive administration of strontium-89 chloride. Clin J Gastroenterol 7, 387–391 (2014). https://doi.org/10.1007/s12328-014-0515-1

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  • DOI: https://doi.org/10.1007/s12328-014-0515-1

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