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Intraocular pressure and endothelium cell counts after cataract surgery with chitosan and sodium hyaluronate (Healon GV): 3-Year follow-up results of a randomised clinical trial

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Abstract

Introduction

The purpose of this study was to evaluate the long-term effects of chitosan 0.1% and sodium hyaluronate 1.4% (Healon GV®; Advanced Medical Optics, Santa Ana, CA, USA) on intraocular pressure (IOP) and endothelial cell loss.

Methods

This randomised study comprised 140 eyes of 140 patients with age-related cataracts undergoing phacoemulsification followed by posterior chamber intraocular lens (IOL) implantation; 70 received chitosan 0.1%, and 70 received sodium hyaluronate 1.4%. The IOP was measured with standard Goldman applanation tonometry pre-operatively and 1 day, 1 week, 1 month, 3 months, 1 year and 3 years postoperatively. Endothelial cell counts were performed pre-operatively and 1 week, 1 month, 3 months, 1 year and 3 years postoperatively using a Pro/Koester WFSCM contact endothelial microscope.

Results

There were no significant differences found in postoperative IOP levels among the chitosan and sodium hyaluronate groups (P>0.05). No significant differences were found in postoperative mean endothelial cell counts at all time points between the chitosan and sodium hyaluronate groups (P>0.05).

Conclusion

Chitosan has the same effects as sodium hyaluronate on IOP and endothelium cells counts after cataract surgery and IOL implantation, and therefore may be an alternative ophthalmic viscoelastic device.

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Authors and Affiliations

  1. Department of Ophthalmology, Second Affiliated Hospital, Second Military Medical University, Shanghai, China

    You Li, Jin-Wei Cheng, Rui-Li Wei & Ji-Ping Cai

  2. Department of Orthopaedics, Second Affiliated Hospital, Second Military Medical University, Shanghai, China

    Chun-Lin Hou

  3. Shanghai Qisheng Biomaterial Institute, Shanghai, China

    Wen-Bin Wang & Qi-Sheng Gu

Authors
  1. You Li
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  2. Jin-Wei Cheng
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  3. Rui-Li Wei
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  4. Chun-Lin Hou
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  5. Wen-Bin Wang
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  6. Qi-Sheng Gu
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  7. Ji-Ping Cai
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Corresponding author

Correspondence to Chun-Lin Hou.

Additional information

You Li and Jin-Wei Cheng contributed equally to this work.

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Li, Y., Cheng, JW., Wei, RL. et al. Intraocular pressure and endothelium cell counts after cataract surgery with chitosan and sodium hyaluronate (Healon GV): 3-Year follow-up results of a randomised clinical trial. Adv Therapy 25, 422–429 (2008). https://doi.org/10.1007/s12325-008-0059-1

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  • DOI: https://doi.org/10.1007/s12325-008-0059-1

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