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Postural Instability in Prodromal Spinocerebellar Ataxia Type 2: Insights into Cerebellar Involvement Before Onset of Permanent Ataxia

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References

  1. Maas R, van Gaalen J, Klockgether T, van de Warrenburg B. The preclinical stage of spinocerebellar ataxias. Neurology. 2015;85:96–103.

    Article  PubMed  Google Scholar 

  2. Velázquez-Pérez L, Rodríguez-Labrada R, Cruz-Rivas EM, et al. Comprehensive study of early features in spinocerebellar ataxia 2: delineating the prodromal stage of the disease. Cerebellum. 2014;13(5):568–79.

    Article  PubMed  Google Scholar 

  3. Velázquez-Pérez L, Rodríguez-Labrada R, Canales-Ochoa N, et al. Progression of early features of spinocerebellar ataxia type 2 in individuals at risk: a longitudinal study. Lancet Neurol. 2014;13(5):482–9.

    Article  PubMed  Google Scholar 

  4. Globas C, du Montcel ST, Baliko L, et al. Early symptoms in spinocerebellar ataxia type 1, 2, 3, and 6. Mov Disord. 2008;23(15):2232–8.

    Article  PubMed  Google Scholar 

  5. Schmitz-Hubsch T et al. Scale for the assessment and rating of ataxia: development of a new clinical scale. Neurology. 2006;66:1717–20.

    Article  CAS  PubMed  Google Scholar 

  6. Imbert G, Saudou F, Yvert G, et al. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. Nat Genet. 1996;14(3):285–91.

    Article  CAS  PubMed  Google Scholar 

  7. Pulst SM, Nechiporuk A, Nechiporuk T, Gispert S, Chen XN, Lopes-Cendes I, et al. Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2. Nat Genet. 1996;14:269–76.

    Article  CAS  PubMed  Google Scholar 

  8. Inagaki A, Iida A, Matsubara M, Inagaki H. Positron emission tomography and magnetic resonance imaging in spinocerebellar ataxia type 2: a study of symptomatic and asymptomatic individuals. Eur J Neurol. 2005;12(9):725–8.

    Article  CAS  PubMed  Google Scholar 

  9. Morton SM, Bastian AJ. Cerebellar control of balance and locomotion. Neuroscientist. 2004;10(3):247–59.

    Article  PubMed  Google Scholar 

  10. Loffe ME. Cerebellar control of posture. Cerebellar control of posture. Handbook of the cerebellum and cerebellar disorders; 2013. p. 1221–1240.

  11. Smeets CJ, Verbeek DS. Climbing fibers in spinocerebellar ataxia: a mechanism for the loss of motor control. Neurobiol Dis. 2016;88:96–106.

    Article  CAS  PubMed  Google Scholar 

  12. Ruegsegger C, Stucki DM, Steiner S, Angliker N, Radecke J, Keller E, et al. Impaired mTORC1-dependent expression of homer-3 influences SCA1 pathophysiology. Neuron. 2016;89(1):129–46.

    Article  CAS  PubMed  Google Scholar 

  13. Buttner N, Geschwind D, Jen JC, Perlman S, Pulst SM, Baloh RW. Oculomotor phenotypes in autosomal dominant ataxias. Arch Neurol. 1998;55(10):1353–7.

    Article  CAS  PubMed  Google Scholar 

  14. Velázquez-Pérez L, Seifried C, Abele M, Wirjatijasa F, et al. Saccade velocity is reduced in presymptomatic spinocerebellar ataxia type 2. Clin Neurophysiol. 2009;120(3):632–5.

    Article  PubMed  Google Scholar 

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Acknowledgments

We are grateful to SCA2 preclinical carriers and the control individuals, to the Cuban Ministry of Public Health, and to TECE Entreprice for its technical support.

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Authors and Affiliations

  1. Center for Research and Rehabilitation of Hereditary Ataxias, Calle Libertad No. 26 Reparto El Llano, 80100, Holguin, Cuba

    Luis Velázquez-Pérez, Gilberto Sánchez-Cruz, Roberto Rodríguez-Labrada, Mercedes Velázquez-Manresa, Ricardo Hechavarría-Pupo & Luis E. Almaguer-Mederos

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  1. Luis Velázquez-Pérez
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  2. Gilberto Sánchez-Cruz
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  3. Roberto Rodríguez-Labrada
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  4. Mercedes Velázquez-Manresa
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  5. Ricardo Hechavarría-Pupo
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  6. Luis E. Almaguer-Mederos
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Correspondence to Luis Velázquez-Pérez.

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Velázquez-Pérez, L., Sánchez-Cruz, G., Rodríguez-Labrada, R. et al. Postural Instability in Prodromal Spinocerebellar Ataxia Type 2: Insights into Cerebellar Involvement Before Onset of Permanent Ataxia. Cerebellum 16, 279–281 (2017). https://doi.org/10.1007/s12311-016-0771-3

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  • DOI: https://doi.org/10.1007/s12311-016-0771-3

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