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Dendritic Translocation of Climbing Fibers: A New Face of Old Phenomenon

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Abstract

During postnatal development of the cerebellum, the number of climbing fibers that innervate individual Purkinje cells decreases from many to one. This is one of the most characterized models of activity-dependent refinement of synaptic circuitry in the mammalian brain. As surplus climbing fibers are eliminated, subcellular location of climbing fiber terminals moves from the soma to the dendrites of Purkinje cells. The role of this dendritic translocation in climbing fiber elimination has been under debate for a long time, but recent studies have significantly changed the view. Traditionally, dendritic translocation was considered neither sufficient nor necessary for climbing fiber elimination, but experimental evidence obtained over the past 5 years indicates crucial roles of dendritic translocation for selectively maintaining one fiber while removing all the others. Here, I provide an overview of (i) several key findings that have contributed for developing the traditional and current views of dendritic translocation, (ii) how our novel experimental approach supports the current view, and (iii) a remaining question that is yet to be answered.

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References

  1. Sugihara I, Wu H, Shinoda Y. Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat. J Comp Neurol. 1999;414(2):131–48.

    Article  CAS  PubMed  Google Scholar 

  2. Crepel F, Mariani J, Delhaye-Bouchaud N. Evidence for a multiple innervation of Purkinje cells by climbing fibers in the immature rat cerebellum. J Neurobiol. 1976;7(6):567–78.

    Article  CAS  PubMed  Google Scholar 

  3. Hashimoto K, Kano M. Synapse elimination in the developing cerebellum. Cell Mol Life Sci. 2013;70(24):4667–80.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Katz LC, Shatz CJ. Synaptic activity and the construction of cortical circuits. Science. 1996;274(5290):1133–8.

    Article  CAS  PubMed  Google Scholar 

  5. Lichtman JW, Colman H. Synapse elimination and indelible memory. Neuron. 2000;25(2):269–78.

    Article  CAS  PubMed  Google Scholar 

  6. Palay S, Chan-Palay V. Cerebellar cortex: Cytology and organizaion. New York: Springer; 1974.

    Book  Google Scholar 

  7. Hashimoto K, Ichikawa R, Kitamura K, Watanabe M, Kano M. Translocation of a “winner” climbing fiber to the Purkinje cell dendrite and subsequent elimination of “losers” from the soma in developing cerebellum. Neuron. 2009;63(1):106–18.

    Article  CAS  PubMed  Google Scholar 

  8. Sotelo C. Cerebellar synaptogenesis: What we can learn from mutant mice. J Exp Biol. 1990;153:225–49.

    CAS  PubMed  Google Scholar 

  9. Crepel F, Delhaye-Bouchaud N, Guastavino JM, Sampaio I. Multiple innervation of cerebellar Purkinje cells by climbing fibres in staggerer mutant mouse. Nature. 1980;283(5746):483–4.

    Article  CAS  PubMed  Google Scholar 

  10. Mariani J, Changeux JP. Multiple innervation of Purkinje cells by climbing fibers in the cerebellum of the adult staggerer mutant mouse. J Neurobiol. 1980;11(1):41–50.

    Article  CAS  PubMed  Google Scholar 

  11. Guenet JL, Sotelo C, Mariani J. Hyperspiny Purkinje cell, a new neurological mutation in the mouse. J Hered. 1983;74(2):105–8.

    CAS  PubMed  Google Scholar 

  12. Scelfo B, Strata P, Knopfel T. Sodium imaging of climbing fiber innervation fields in developing mouse Purkinje cells. J Neurophysiol. 2003;89(5):2555–63.

    Article  PubMed  Google Scholar 

  13. Carrillo J, Nishiyama N, Nishiyama H. Dendritic translocation establishes the winner in cerebellar climbing fiber synapse elimination. J Neurosci. 2013;33(18):7641–53.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Mikuni T, Uesaka N, Okuno H, Hirai H, Deisseroth K, Bito H, et al. Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum. Neuron. 2013;78(6):1024–35.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Uesaka N, Uchigashima M, Mikuni T, Nakazawa T, Nakao H, Hirai H, et al. Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain. Science. 2014;344(6187):1020–3.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This work was supported by National Institutes of Health Grant NS073919.

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The author declares no competing financial interests

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Authors and Affiliations

  1. Center for Learning and Memory, Department of Neuroscience, The University of Texas at Austin, 1 University Station Stop C7000, Austin, TX, 78712, USA

    Hiroshi Nishiyama

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  1. Hiroshi Nishiyama
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Correspondence to Hiroshi Nishiyama.

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Nishiyama, H. Dendritic Translocation of Climbing Fibers: A New Face of Old Phenomenon. Cerebellum 14, 1–3 (2015). https://doi.org/10.1007/s12311-014-0614-z

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  • DOI: https://doi.org/10.1007/s12311-014-0614-z

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