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Ataxia and HIV: Clinicopathologic Correlations in a Case of HIV-Associated Cerebellar Leukoencephalopathy

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References

  1. Robertson KR, Smurzynski M, Parsons TD, Wu K, Bosch RJ, Wu J, et al. The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS. 2007;21:1915–21.

    Article  PubMed  Google Scholar 

  2. Navia BA, Jordan BD, et al. The AIDS dementia complex: I. Clinical features. Ann Neurol. 1986;19:517–24.

    Article  PubMed  CAS  Google Scholar 

  3. Navia BA, Cho ES, et al. The AIDS dementia complex: II. Neuropathology. Ann Neurol. 1986;19:525–35.

    Article  PubMed  CAS  Google Scholar 

  4. Kessler J, Calabrese P, Kalbe E, Berger F. DemTect. Ein neues Screening-Verfahren zur Unterstützung der Demenzdiagnostik. Psycho. 2000;6:343–7.

    Google Scholar 

  5. Timman-Braun D, Diener H.C. Alcoholic cerebellar degeneration (including ataxias that are due to other toxic causes). In Klockgether, T (ed.) Handbook of ataxia disorders. New York, Marcel Dekker; 2000.

  6. Matschke J, Kromminga A, Erbersdobler A, Lamszus K, Anders S, Köfüncü E. Paraneoplastic cerebellar degeneration and anti-Yo antibodies in a man with prostatic adenocarcinoma. J Neurol Neurosurg Psychiatry. 2007;78:775–7.

    Article  PubMed  CAS  Google Scholar 

  7. Ovbiagele B, Nath A. Increasing incidence of ischemic stroke in patients with HIV infection. Neurology. 2011;76:444–50. Epub 2011 Jan 19.

    Article  PubMed  Google Scholar 

  8. Griffiths P. Cytomegalovirus infection of the central nervous system. Herpes. 2004;11 Suppl 2:95A–104A.

    PubMed  Google Scholar 

  9. Mascarello M, Lanzafame M, Lattuada E, Concia E, Ferrari S. Progressive multifocal leukoencephalopathy in an HIV patient receiving successful long-term HAART. J Neurovirol. 2011;17:196–9.

    Article  PubMed  Google Scholar 

  10. Marzocchetti A, Di Giambenedetto S, Cingolani A, Ammassari A, Cauda R, De Luca A. Reduced rate of diagnostic positive detection of JC virus DNA in cerebrospinal fluid in cases of suspected progressive multifocal leukoencephalopathy in the era of potent antiretroviral therapy. J Clin Microbiol. 2005;43:4175–7.

    Article  PubMed  Google Scholar 

  11. Bates DE, Herman RJ. Carbamazepine toxicity induced by lopinavir/ritonavir and nelfinavir. Ann Pharmacother. 2006;40:1190–5.

    Article  PubMed  Google Scholar 

  12. Reiss KA, Bailey JR, Pham PA, Gallant JE. Raltegravir-induced cerebellar ataxia. AIDS. 2010;24:2757.

    Article  PubMed  Google Scholar 

  13. Elsheikh BH, Maher WE, Kissel JT. Cerebellar atrophy associated with human immunodeficiency virus infection. Arch Neurol. 2010;67:634–5.

    Article  PubMed  Google Scholar 

  14. Kwakwa HA, Ghobrial MW. Primary cerebellar degeneration and HIV. Arch Intern Med. 2001;161:1555–6.

    Article  PubMed  CAS  Google Scholar 

  15. Tagliati M, Simpson D, Morgello S, Clifford D, Schwartz RL, Berger JR. Cerebellar degeneration associated with human immunodeficiency virus infection. Neurology. 1998;50:244–51.

    Article  PubMed  CAS  Google Scholar 

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Conflict of Interest

All authors report no conflicts of interest.

Financial Disclosures

Christos Ganos: commercial research support from grants by Ipsen, Merz Pharmaceuticals; academic research support not attributed in the manuscript are those from Deutsche Forschungsgemeinschaft (MU1692/2-1) and European Science Foundation.

Christian Bernreuther: none.

Jakob Matschke: none.

Christian Gerloff: commercial research support from Honoraria for lectures from Boehringer Ingelheim, Glaxo Smith Kline, Sanofi Aventis and ev3 GmbH; academic research support not attributed in the manuscript are DFG (GE844/2-1, GE844/41), SFB (936 Z1,Z2,C1 2011-2015) and EU FP7 278276.

Alexander Münchau: commercial research support from grants by Pharm Allergan, Ipsen and Merz Pharmaceuticals; honoraria for lectures from Pharm Allergan, Ipsen and Merz Pharmaceuticals; support from a non-profit foundation or society: Dystonia Medical Research Foundation (USA), Tourette syndrome Association (Germany), N.E.MO. Charity supporting the research of paediatric movement disorders; academic research support not attributed in the manuscript from Deutsche Forschungsgemeinschaft (MU1692/2-2).

Frank Leypoldt: none.

All authors are employed at the University Medical Center Hamburg-Eppendorf (UKE).

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Authors and Affiliations

  1. Movement Disorders Group, Department of Neurology, University Medical Center Hamburg–Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany

    Christos Ganos, Christian Gerloff, Alexander Münchau & Frank Leypoldt

  2. Institute of Neuropathology, University Medical Center Hamburg–Eppendorf (UKE), 20246, Hamburg, Germany

    Christian Bernreuther & Jakob Matschke

Authors
  1. Christos Ganos
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  2. Christian Bernreuther
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  3. Jakob Matschke
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  4. Christian Gerloff
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  5. Alexander Münchau
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  6. Frank Leypoldt
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Corresponding author

Correspondence to Christos Ganos.

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Video 1

Neurological examination 4 years after onset of cerebellar symptoms showing cerebellar dysarthria, saccadic initiation difficulties with compensatory head thrust, slowing of saccades, gaze-evoked upward-beating nystagmus, axial ataxia with titubation, brady- and dysdiadochokinesia and dysgraphia. Additionally, intention tremor and movement decomposition are seen during finger-to-nose and heel-to-shin testing. The patient’s gait is wide-based, slowed, with reduced stride length and outward hip rotation. Romberg test is positive. The International Cooperative Ataxia Rating Scale Score (ICARS) was 50 (WMV 8826 kb)

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Ganos, C., Bernreuther, C., Matschke, J. et al. Ataxia and HIV: Clinicopathologic Correlations in a Case of HIV-Associated Cerebellar Leukoencephalopathy. Cerebellum 11, 816–819 (2012). https://doi.org/10.1007/s12311-011-0345-3

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