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Monocytes and Macrophages in Cancer: Development and Functions

  • Original Article
  • Published:
Cancer Microenvironment

Abstract

Monocytes and tumor-associated macrophages are part of the myeloid family, a group of hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell-derived macrophages. After their recruitment into the tumor tissue, they can differentiate into tumor-associated macrophages, a very heterogeneous cell population in terms of phenotype and pro-tumor function, supporting tumor initiation, local progression and distant metastasis. Therefore, targeting monocytes and macrophages is a promising immunotherapeutic approach. This review will focus on the development of monocytes as macrophage precursors, the functions of tumor-associated macrophages and the possibility of interfering with tumor development and progression by targeting these myeloid cells.

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Acknowledgments

This work was supported by a grant from the Helmholtz Association of German Research Centers (HGF; HZ-NG-505) to M.F. and J.H. was supported by a HGF-PhD-fellowship. The authors declare no competing financial interests.

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  1. Immune Tolerance, Tumor Immunology Program, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    David M. Richards, Jan Hettinger & Markus Feuerer

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  1. David M. Richards
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  2. Jan Hettinger
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  3. Markus Feuerer
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Correspondence to Markus Feuerer.

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David M. Richards and Jan Hettinger equally contributed.

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Richards, D.M., Hettinger, J. & Feuerer, M. Monocytes and Macrophages in Cancer: Development and Functions. Cancer Microenvironment 6, 179–191 (2013). https://doi.org/10.1007/s12307-012-0123-x

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