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Failed back surgery syndrome: a new strategy by the epidural injection of MESNA

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MUSCULOSKELETAL SURGERY Aims and scope Submit manuscript

Abstract

Purpose

Evaluate the efficacy and safety of MESNA (sodium 2-mercaptoethanesulfonate) injection into the epidural space in the FBSS.

Methods

We designed a prospective phase II longitudinal study. Six consecutive patients were enrolled. Patients underwent one peridural injection per week for 3 weeks. NRS and ODI were investigated before and 48 h after injections, and at 1 week, 1 month and 2 months after the last procedures. Opioids intake is investigated before procedures and 1 week, 1 month and 3 months after the last procedures. Lumbosacral MRI is performed before the first procedure, at the end and 3 months after the last procedures.

Results

From baseline, at 3 months, NRS in standing, sitting and lying position improved, respectively, of 34.29, 30.56 and 26.47%; ODI improved of 20.3%; the average decrease in morphine intake was 20.54%. No difference in MR images was found. Conclusions Our preliminary results suggest that MESNA might be an efficacy alternative to common practice.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Resuscitation and Pain Medicine, CIR – Center of Integrated Research, University Campus Bio-Medico of Rome, Rome, Italy

    M. Carassiti, A. Centonze & F. Agrò

  2. Department of Orthopaedics and Trauma Surgery, CIR – Center of Integrated Research, University Campus Bio-Medico of Rome, Rome, Italy

    A. Di Martino, A. Caldaria & V. Denaro

  3. Department of Diagnostic Imaging, CIR – Center of Integrated Research, University Campus Bio-Medico of Rome, Rome, Italy

    C. C. Quattrocchi

Authors
  1. M. Carassiti
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  2. A. Di Martino
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  3. A. Centonze
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  4. C. C. Quattrocchi
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  5. A. Caldaria
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  6. F. Agrò
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  7. V. Denaro
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Corresponding author

Correspondence to A. Di Martino.

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Conflict of interest

We have patented the peridural use of MESNA (IPN WO2012/052888 A1 and Italian Patent #0001402161): property of the patent is the Institution University Campus Bio-Medico of Rome; royalties are not personal to the authors, but devolved to the Institutional Research of the Respective Departments of the Authors.

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Carassiti, M., Di Martino, A., Centonze, A. et al. Failed back surgery syndrome: a new strategy by the epidural injection of MESNA. Musculoskelet Surg 102, 179–184 (2018). https://doi.org/10.1007/s12306-017-0520-x

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  • DOI: https://doi.org/10.1007/s12306-017-0520-x

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