Abstract
Low-grade fibromyxoid sarcoma (LGFMS) was first described by Evans in 1987, and since then, just over 150 cases have been reported, showing the rarity of this tumor. We report the clinical case of a 56-year-old man with a swelling on the distal third of the left thigh. The mass had grown in the course of 1 year and was surgically excised, obtaining complete resolution. Immuno-histological examination demonstrated the lesion to be a LGFMS, defined as a benign tumor but with a high incidence of local and distant recurrence (5–10%). At 2-year follow-up the patient was disease-free, confirming the efficacy of the surgical excision. In literature, the frequency of incomplete excision of LGFMS due to inappropriate diagnosis is stressed. It is this element that contributes most to the high rate of recurrence. We recommend that the eventuality of observing this rare tumor be borne in mind, and that care be taken to perform a complete, ample excision.
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Evans HL (1987) Low-grade fibromyxoid sarcoma. A report of two metastasizing neoplasms having a deceptively benign appearance. Am J Clin Pathol 88(5):615–619
Evans HL (1993) Low-grade fibromyxoid sarcoma. A report of 12 cases. Am J Surg Pathol 17:595–600
Goodlad JR, Mentzel T, Fletcher CD (1995) Low grade fibromyxoid sarcoma: clinicopathological analysis of eleven new cases in support of a distinct entity. Histopathology 26:229–237
Torriani M, Etchebehere M, Amstalden EM, Ouellette H (2006) Magnetic resonance imaging of low-grade fibromyxoid sarcoma. Clinics 61(3):267–270
Lindberg GM, Maitra A, Gokaslan ST, Saboorian MH, Albores-Saavedra J (1999) Low grade fibromyxoid sarcoma: fine-needle aspiration cytology with histologic, cytogenetic, immunohistochemical, and ultrastructural correlation. Cancer 87:75–82
Mezzelani A, Sozzi G, Nessling M, Riva C, Della Torre G, Testi MA, Azzarelli A, Pierotti MA, Lichter P, Pilotti S (2000) Low grade fibromyxoid sarcoma a further low-grade soft tissue malignancy characterized by a ring chromosome. Cancer Genet Cytogenet 122:144–148
Domanski HA, Mertens F, Panagopoulos I, Akerman M (2009) Low-grade fibromyxoid sarcoma is difficult to diagnose by fine needle aspiration cytology: a cytomorphological study of eight cases. Cytopathology 14:1–11
Folpe AL, Lane KL, Paull G, Weiss SW (2000) Low-grade fibromyxoid sarcoma and hyalinizing spindle cell tumor with giant rosettes: a clinicopathologic study of 73 cases supporting their identity and assessing the impact of high-grade areas. Am J Surg Pathol 24(10):1353–1360
Billings SD, Giblen G, Fanburg-Smith JC (2005) Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population. Am J Surg Pathol 29:204–210
Park IJ, Kim HC, Yu CS, Kim JS, Jang SJ, Kim JC (2007) Low-grade fibromyxoid sarcoma of the colon. Dig Liver Dis 39:274–277
Winfield HL, De Las Casas LE, Greenfield WW, Santin AD, McKenney JK (2007) Low-grade fibromyxoid sarcoma presenting clinically as a primary ovarian neoplasm: a case report. Int J Gynecol Pathol 26:173–176
Koishi A, Gomibuchi H, Inoue J, Minoura S, Itoh E, Saito M (2003) Hyalinizing spindle cell tumor with giant rosettes of the omentum. J Obstet Gynaecol Res 29:388–391
Colović R, Grubor N, Misev M, Jovanović M, Radak V (2008) Fibromyxoid sarcoma of the pancreas. Srp Arh Celok Lek 136(3–4):158–161
Saito R, Kumabe T, Watanabe M, Jokura H, Shibuya M, Nakazato Y, Tominaga T (2008) Low-grade fibromyxoid sarcoma of intracranial origin. J Neurosurg 108(4):798–802
Botev B, Casale M, Vincenzi B, D’Ascanio L, Santini D, Esposito V, Di Marino MP, Baldi A, Rinaldi V, Tonini G, Salvinelli F (2006) A giant sarcoma of the parotid gland: a case report and review of the literature. In Vivo 20(6B):907–910
Jakowski JD, Wakely PE (2008) Primary intrathoracic low-grade fibromyxoid sarcoma. Hum Pathol 39:623–628
Canpolat C, Evans HL, Corpron C, Andrassy RJ, Chan K, Eifel P, Elidemir O, Raney B (1996) Fibromyxoid sarcoma in a four-year-old child: case report and review of the literature. Med Pediatr Oncol 27(6):561–564
Cabibi D (2007) Letter to the editor. Pathol Int 57:458
Kusumi T, Nishikawa S, Tanaka M, Ogawa T, Jin H, Sato F, Toh S, Hasegawa T, Kijima H (2005) Low-grade fibromyxoid sarcoma arising in the big toe. Pathol Int 55:802–806
Fujii S, Kawawa Y, Horiguchi S, Kamata N, Kinoshita T, Ogawa T (2008) Low-grade fibromyxoid sarcoma of the small bowel mesentery: computed tomography and magnetic resonance imaging findings. Radiat Med 26(4):244–247
Antonescu CR, Baren A (2004) Spectrum of low-grade fibrosarcomas: a comparative ultrastructural analysis of low-grade myxofibrosarcoma and fibromyxoid sarcoma. Ultrastruc Pathol 28:321–332
Ugai K, Kizaki T, Morimoto K, Sashikata T (1994) A case of low-grade fibromyxoid sarcoma of the thigh. Pathol Int 44:793–799
Fukunaga M, Ushigome S, Fukunaga N (1996) Low grade fibromyxoid sarcoma. Virchows Arch 429:301–303
Lee BJ, Park WS, Jin JM, Ha CW, Lee SH (2009) Low grade fibromyxoid sarcoma in thigh. Clin Orthop Surg 1(4):240–243
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Notarnicola, A., Moretti, L., Cocca, M.P. et al. Low-grade fibromyxoid sarcoma of the medial vastus: a case report. Musculoskelet Surg 94, 109–112 (2010). https://doi.org/10.1007/s12306-010-0075-6
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DOI: https://doi.org/10.1007/s12306-010-0075-6